Patents by Inventor Randall J. Daughenbaugh
Randall J. Daughenbaugh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20070214658Abstract: A triangular chain saw guide bar is disclosed which may be used as a replacement for a conventional guide bar and which allows for cutting using a pushing rather than a swinging motion.Type: ApplicationFiled: March 15, 2007Publication date: September 20, 2007Inventors: Russell Payton, Randall J. Daughenbaugh
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Patent number: 6498150Abstract: The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.Type: GrantFiled: October 7, 1999Date of Patent: December 24, 2002Assignee: Dovetail Technologies, Inc.Inventors: Floyd Taub, Thomas J. Perun, Christopher K. Murray, Randall J. Daughenbaugh, Daniel Lednicer
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Patent number: 6414114Abstract: The present invention is directed to novel disulfides and thiols that are of up to about eighteen amino acids. One example, is a compound of the formula (1): A—B—C—S—S—D—E—F, wherein: A and F are selected from the group consisting of hydrogen, an amino acid, a dipeptide, a tripeptide, a modified polypeptide up to three amino acids long, and a carbobenzoxy groups, B and E are selected from the group consisting of an amino acid, a dipeptide, a tripeptide, and a modified polypeptide comprising up to and including three amino acids, C and D are selected from the group consisting of a modified polypeptide and a polypeptide comprising up to and including three amino acids, and S is the sulfur atom in the modified polypeptide and the polypeptide in C and D.Type: GrantFiled: February 24, 1999Date of Patent: July 2, 2002Assignee: Dovetail Technologies, Inc.Inventors: Floyd E. Taub, Christopher K. Murray, Randall J. Daughenbaugh, Daniel Lednicer
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Publication number: 20020082459Abstract: The process of the present invention relates to the isolation and purification of both a natural mixed carotenoid product and an all-trans-&bgr;-carotene product from various different biomass sources, preferably from algae of the genus Dunaliella. More particularly, the present invention relates to a single solvent process whereby both natural and colorant products lie along the same process line. The nutritional product contains the natural array of carotenes and xanthophylls found in the plant material, while the colorant product contains primarily trans-&bgr;-carotene.Type: ApplicationFiled: November 16, 2001Publication date: June 27, 2002Inventors: David T. Bailey, Randall J. Daughenbaugh, Robert Arslanian, Leonard A. Kaufmann, Steven L. Richheimer, Zhengjie Z. Liu, James M. Piffarerio, Chris J. Kurtz
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Publication number: 20020035118Abstract: The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.Type: ApplicationFiled: October 7, 1999Publication date: March 21, 2002Inventors: FLOYD TAUB, THOMAS J. PERUN, CHRISTOPHER K. MURRAY, RANDALL J. DAUGHENBAUGH, DANIEL LEDNICER
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Publication number: 20010008933Abstract: The present invention is directed to novel disulfides and thiols that are of up to about eighteen amino acids. One example, is a compound of the formula (1): A-B-C-S-S-D-E-F, wherein: A and F are selected from the group consisting of hydrogen, an amino acid, a dipeptide, a tripeptide, a modified polypeptide up to three amino acids long, and a carbobenzoxy group, B and E are selected from the group consisting of an amino acid, a dipeptide, a tripeptide, and a modified polypeptide comprising up to and including three amino acids, C and D are selected from the group consisting of a modified polypeptide and a polypeptide comprising up to and including three amino acids, and S is the sulfur atom in the modified polypeptide and the polypeptide in C and D.Type: ApplicationFiled: February 24, 1999Publication date: July 19, 2001Inventors: FLOYD E. TAUB, CHRISTOPHER K. MURRAY, RANDALL J. DAUGHENBAUGH
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Patent number: 6160004Abstract: The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10 carbon-substituted trioxanes of structure: ##STR1## wherein, when n is 1, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, acetylenics, or benzoylmethylenes, or alkanoylmethylenes; or when n is 2, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes; or when n is 3, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes.Type: GrantFiled: October 30, 1998Date of Patent: December 12, 2000Assignees: Hauser, Inc., Johns Hopkins UniversityInventors: Gary H. Posner, Soon Hyung Woo, Poonsakdi Ploypradith, Michael H. Parker, Theresa A. Shapiro, Jeffrey S. Elias, John Northrop, Qun Y. Zheng, Christopher Murray, Randall J. Daughenbaugh
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Patent number: 6156790Abstract: The present invention provides a two-step procedure for the replacement of the pyranose anomeric 10-OH group in dihydroartemisinin by a variety of carbon nucleophiles, resulting in the novel C-10 carbon-substituted trioxanes of structure: ##STR1## wherein, when n is 1, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, acetylenics, or benzoylmethylenes, or alkanoylmethylenes; or when n is 2, R is selected from a group of unsubstituted or substituted aryls, heteroaryls, polyethylene glycol, alkenyls, alkyls, diketones or bis-acetylenes.Type: GrantFiled: December 30, 1997Date of Patent: December 5, 2000Assignees: Hauser, Inc., Johns Hopkins UniversityInventors: Gary H. Posner, Soon Hyung Woo, Poonsakdi Ploypradith, Michael H. Parker, Theresa A. Shapiro, Qun Y. Zheng, Christopher Murray, Randall J. Daughenbaugh
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Patent number: 6132726Abstract: In general the present invention relates to a process for the removal of undesireable compounds or residues from an extract which are more polar or less polar than the desired target compound. The preferred embodiment of the present invention is a three step process and is described in detail below. The first step includes contacting a plant material that contains the desired target compound(s) with a solvent, thus producing a crude extract containing a mixture of compounds that includes, in addition to the undesireable residues, the desired target compound(s). The second step involves passing the crude extract through a series of columns containing an absorbent that retards the movement of the undesireable compounds, while allowing the desired compounds to pass. The third and final step involves drying the eluant product to achieve a final product.Type: GrantFiled: October 21, 1998Date of Patent: October 17, 2000Assignee: Hauser, Inc.Inventors: Randall J. Daughenbaugh, David T. Bailey, William R. Gamble, Dennis D. Gertenbach
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Patent number: 6007819Abstract: The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.Type: GrantFiled: October 17, 1996Date of Patent: December 28, 1999Assignee: Dovetail Technologies, Inc.Inventors: Floyd Taub, Thomas J. Perun, Christopher K. Murray, Randall J. Daughenbaugh, Daniel Lednicer
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Patent number: 6004997Abstract: Novel trioxane dimers of structure ##STR1## which possess antiproliferative and antitumor activities.Type: GrantFiled: November 23, 1998Date of Patent: December 21, 1999Assignees: Hauser, Inc., Johns Hopkins UniversityInventors: Qun Y. Zheng, Christopher Murray, Randall J. Daughenbaugh, Poonsakdi Ploypradith, Gary H. Posner
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Patent number: 5892063Abstract: An antitumor compound of formula (5) ##STR1## in which R is Ac or H, and R.sub.1, R.sub.2 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R.sub.3 is H; R.sub.1 and R.sub.2 and R.sub.3 are H; R.sub.1 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R.sub.2, R.sub.3 is H; R.sub.1 and R.sub.3 are H, R.sub.2 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R.sub.1 is H, R.sub.2 and R.sub.3 are an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R.sub.1 and R.sub.2 and R.sub.3 are an alkyl group Me, Et, Pr, i-Pr, n-Bu or t-Bu. Me is an abbreviation for methyl, Et is ethyl, Pr is propyl, i-Pr is isopropyl, n-Bu is n-butyl, and t-Bu is tert-butyl. Also provided by the invention is a one step method of preparing a compound of formula (5) whereby a taxane having a tiglate group attached to the side chain is contacted with an oxidizing reagent resulting in the formation of an epoxide having antitumor activity.Type: GrantFiled: May 21, 1997Date of Patent: April 6, 1999Assignee: Hauser, Inc.Inventors: Qun Y. Zheng, Christopher K. Murray, Randall J. Daughenbaugh
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Patent number: 5840925Abstract: Described herein are novel trioxane dimers of structure ##STR1## which possess antiproliferative and antitumor activities.Type: GrantFiled: December 2, 1996Date of Patent: November 24, 1998Assignee: Hauser, Inc.Inventors: Qun Y. Zheng, Christopher Murray, Randall J. Daughenbaugh, Poonsakdi Ploypradith, Gary H. Posner
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Patent number: 4647663Abstract: This invention relates to an improved process for producing morpholine. The improvement resides in continuously charging the diethylene glycol and ammonia to a first trickle bed reactor, operating the reactor under conditions such that the diethylene glycol is maintained as a discontinuous liquid phase and the morpholine formed is predominantly in the vapor phase, separating the reaction products into a morpholine stream and a 2-(2,aminoethoxy)ethanol stream, and then charging the 2-(2,aminoethoxy)ethanol stream to a second trickle bed reactor and then reacting with ammonia to produce morpholine.Type: GrantFiled: May 25, 1982Date of Patent: March 3, 1987Assignee: Air Products and Chemicals, Inc.Inventors: Dale D. Dixon, Randall J. Daughenbaugh
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Patent number: 4645834Abstract: This invention relates to an improved process for producing morpholine and its derivates by reacting ammonia and dialkylene glycol. The improvement resides in continuously charging the dialkylene glycol and ammonia to a trickle bed reactor, operating the reactor under conditions such that the dialkylene glycol is maintained as a discontinuous liquid phase and the morpholine formed is predominantly in the vapor phase.Type: GrantFiled: April 8, 1982Date of Patent: February 24, 1987Assignee: Air Products and Chemicals, Inc.Inventors: Dale D. Dixon, Randall J. Daughenbaugh, Robert L. Fowlkes
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Patent number: 4417074Abstract: A process for preparing allylic amines which comprises contacting an allylic alcohol with ammonia or a primary or secondary amine in the presence of an effective amount of a phosphorus containing substance at a temperature sufficient to effect a reaction between the allylic alcohol and the ammonia or organic amine to produce an allylic amine.Type: GrantFiled: October 22, 1981Date of Patent: November 22, 1983Assignee: Air Products and Chemicals, Inc.Inventors: Randall J. Daughenbaugh, Dale D. Dixon
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Patent number: 4313005Abstract: This invention relates to a process for reducing amidine formation during reduction of organonitriles. The process comprises including a boron compound in the reaction medium in sufficient amount to complex the amidine compound as it is formed.Type: GrantFiled: April 3, 1980Date of Patent: January 26, 1982Assignee: Air Products and Chemicals, Inc.Inventors: Michael E. Ford, Randall J. Daughenbaugh
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Patent number: 4289908Abstract: This invention relates to an improvement in a process for preparing lower acyclic saturated amines by the gas phase hydrogenation of nitriles. To carry out the gas phase hydrogenation, the temperatures utilized in the reaction zone are from about 150.degree. to 350.degree. C., the pressure from about atmospheric to 500 psia, and the space velocity from about 750-20,000. Preferably, the conditions are controlled such that the components in the reaction zone are not exposed to a temperature greater than 380.degree. C. for a period of time in excess of 0.03 seconds.Type: GrantFiled: July 19, 1979Date of Patent: September 15, 1981Assignee: Air Products and Chemicals, Inc.Inventors: Eckhart R. Becker, Randall J. Daughenbaugh, Barton Milligan
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Patent number: 4260748Abstract: Morpholine is produced by the catalytic hydrogenation of bis (cyanomethyl) ether.Type: GrantFiled: March 7, 1980Date of Patent: April 7, 1981Assignee: Air Products and Chemicals, Inc.Inventors: Dale D. Dixon, Randall J. Daughenbaugh
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Patent number: RE38117Abstract: Described herein are novel trioxane dimers of structure which possess antiproliferative and antitumor activities.Type: GrantFiled: November 21, 2000Date of Patent: May 6, 2003Assignees: Hauser, Inc., Johns HopkinsInventors: Qun Y. Zheng, Christopher Murray, Randall J. Daughenbaugh, Poonsakdi Ploypradith, Gary H. Posner