Patents by Inventor Randall J. Mrsny

Randall J. Mrsny has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PSEUDOMONAS EXOTOXIN A-LIKE CHIMERIC IMMUNOGENS FOR ELICITING A SECRETORY IGA-MEDIATED IMMUNE RESPONSE
    Publication number: 20090081235
    Abstract: This invention provides methods of eliciting a secretory IgA-mediated immune response in a subject by administering a Pseudomonas exotoxin A-like chimeric immunogens that include a non-native epitope in the Ib domain of Pseudomonas exotoxin. Compositions comprising secretory IgA antibodies that specifically recognize an epitope of HIV-1 also are provided.
    Type: Application
    Filed: July 8, 2008
    Publication date: March 26, 2009
    Applicants: OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, GENENTECH, INC.
    Inventors: DAVID J. FITZGERALD, RANDALL J. MRSNY
  • PSEUDOMONAS EXOTOXIN A-LIKE CHIMERIC IMMUNOGENS FOR ELICITING A SECRETORY IGA-MEDIATED IMMUNE RESPONSE
    Publication number: 20030054012
    Abstract: This invention provides methods of eliciting a secretry IgA-mediated immune response in a subject by administering a Pseudomonas exotoxin A-like chimeric immunogens that include a non-native epitope in the Ib domain of Pseudomonas exotoxin.
    Type: Application
    Filed: May 12, 2000
    Publication date: March 20, 2003
    Inventors: DAVID J. FITZGERALD, RANDALL J. MRSNY
  • Cystic fibrosis therapy
    Patent number: 6033688
    Abstract: The invention provides methods for treating cystic fibrosis and other pathological conditions in mammals using hepatocyte growth factor ("HGF"). The invention also provides articles of manufacture and kits containing HGF.
    Type: Grant
    Filed: September 2, 1997
    Date of Patent: March 7, 2000
    Assignees: Genentech, Inc., The Regents of the University of California, Children's Hospital Medical Center of Northern California
    Inventors: Randall J. Mrsny, Ben-Quan Shen, Jonathan H. Widdicombe
  • Cystic fibrosis therapy
    Patent number: 5855918
    Abstract: The invention provides methods for treating cystic fibrosis and other pathological conditions in mammals using hepatocyte growth factor ("HGF"). The invention also provides articles of manufacture and kits containing HGF.
    Type: Grant
    Filed: September 12, 1996
    Date of Patent: January 5, 1999
    Assignees: Genentech, Inc., Children's Hospital Medical Center of Northern California, Regents of the University of CA
    Inventors: Randall J. Mrsny, Ben-Quan Shen, Jonathan H. Widdicombe
  • Crosslinking receptor-specific probes for electron microscopy
    Patent number: 4879220
    Abstract: A method and probes are disclosed for the localization of functional receptors by electron microscopy (EM). Electron dense probes are directed to receptors by means of specific ligand-receptor interactions and subsequently anchored covalently to target cellular material. A particular probe is a complex between colloidal gold and dextran derivatized with diaminohexane and containing photo-activatable nitroarylazido groups. Ligands with a specific affinity for certain receptors can be covalently attached to the complex to provide receptor-specific markers. For example, ouabain can be covalently attached to the dextran matrix to produce a probe specific for functional units of Na,K-ATPase. Covalent attachment of the bound probes at or near their respective receptors greatly enhances retention of probe during washing and standard procedures of fixation and dehydration in preparation for EM.
    Type: Grant
    Filed: November 18, 1986
    Date of Patent: November 7, 1989
    Assignee: State of Oregon Acting By and Through the State Board of Higher Education On Behalf of the University of Oregon
    Inventors: Randall J. Mrsny, G. Bruce Birrell, Johannes J. Volwerk