Patents by Inventor Randall Lee Carter
Randall Lee Carter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9125955Abstract: An embodiment of the invention comprises method of imaging a target site comprising administrating ligand of Formula I complexed to 99mTc wherein R1 and R2 are independently an alkyl or cycloalkyl; R3 is and alkyl; X is CO or SO2; Y is (CH2)n, C6H4, (OCH2CH2)n(NHCH2CH2)n and (OCH2CH2CH2)n, or a combination thereof; Z is linker group capable of conjugating to a vector; and n is an integer between 0 and 10.Type: GrantFiled: November 6, 2013Date of Patent: September 8, 2015Assignee: General Electric CompanyInventors: Bruce Fletcher Johnson, Randall Lee Carter, Michael James Rishel, Mark Christopher Patrick Darey, Tao Wu, Yang Yang, John Fitzmaurice Valliant, Karin Ann Stephenson
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Patent number: 8927732Abstract: The present teachings provide methods that enable the preparation and purification of radioiodinated vectors without the need for HPLC purification, as well as novel precursors which include biotin-like substituents useful in such methods.Type: GrantFiled: March 30, 2012Date of Patent: January 6, 2015Assignee: General Electric CompanyInventors: Randall Lee Carter, Bruce Fletcher Johnson, Anup Sood, Michael James Rishel, John Fitzmaurice Valliant, Karin Ann Stephenson, Tao Wu, Yang Yang
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Publication number: 20140065065Abstract: An embodiment of the invention comprises method of imaging a target site comprising administrating ligand of Formula I complexed to 99mTc wherein R1 and R2 are independently an alkyl or cycloalkyl; R3 is and alkyl; X is CO or SO2; Y is (CH2)n, C6H4, (OCH2CH2)n (NHCH2CH2)n and (OCH2CH2CH2)n, or a combination thereof; Z is linker group capable of conjugating to a vector; and n is an integer between 0 and 10.Type: ApplicationFiled: November 6, 2013Publication date: March 6, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Bruce Fletcher Johnson, Randall Lee Carter, Michael James Rishel, Mark Christopher Patrick Darey, Tao Wu, Yang Yang, John Fitzmaurice Valliant, Karin Ann Stephenson
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Patent number: 8617515Abstract: The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the agent, and determining myelination in the subject by detecting binding to myelin basic protein. Methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using an agent with specific binding to myelin basic protein are also provided as is a kit containing the agent or its derivatives for use in detecting myelin basic protein.Type: GrantFiled: June 4, 2009Date of Patent: December 31, 2013Assignee: General Electric CompanyInventors: Cristina Abucay Tan Hehir, Tiberiu Mircea Siclovan, Nicole Evelyn Barnhardt, Kenneth Michael Fish, Randall Lee Carter, Bruce Fletcher Johnson
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Publication number: 20130261311Abstract: The present teachings provide methods that enable the preparation and purification of radioiodinated vectors without the need for HPLC purification, as well as novel precursors which include biotin-like substituents useful in such methods.Type: ApplicationFiled: March 30, 2012Publication date: October 3, 2013Applicants: Centre for Probe Development and Commercialization, General Electric CompanyInventors: Randall Lee Carter, Bruce Fletcher Johnson, Anup Sood, Michael James Rishel, John Fitzmaurice Valliant, Karin Ann Stephenson, Tao Wu, Yang Yang
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Publication number: 20130195756Abstract: An embodiment of the invention comprises a ligand of Formula I wherein R1 and R2 are independently an alkyl or cycloalkyl; R3 is and alkyl; X is CO or SO2; Y is (CH2)n, C6H4, (OCH2CH2)n(NHCH2CH2)n and (OCH2CH2CH2)n, or a combination thereof; Z is linker group capable of conjugating to a vector; and n is an integer between 0 and 10. Also included are an imaging agent comprising a compound of Formula I complexed to 99mTc and their method of use to image a subject having a target site using single photon emission computed tomography (SPECT).Type: ApplicationFiled: January 31, 2012Publication date: August 1, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Bruce Fletcher Johnson, Randall Lee Carter, Michael James Rishel, Mark Christopher Patrick Darey, Tao Wu, Yang Yang, John Fitzmaurice Valliant, Karin Ann Stephenson
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Publication number: 20120114563Abstract: The present invention relates to a method of in vivo optical imaging, of the margins around tumours, which comprises an optical imaging contrast agent. The optical imaging agents comprise conjugates of near-infrared dyes with synthetic polyethylene glycol (PEG) polymers having a molecular weight in the range 15-45 kDa. Also disclosed are optical imaging contrast agents, pharmaceutical compositions and kits.Type: ApplicationFiled: March 19, 2010Publication date: May 10, 2012Applicant: GENERAL ELECTRIC COMPANYInventors: Randall Lee Carter, Jason William Castle, Kenneth Michael Fish, Anup Sood, Natalie Anne Staples, Brian Duh-Lan Lee
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Publication number: 20100310457Abstract: The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the agent, and determining myelination in the subject by detecting binding to myelin basic protein.Type: ApplicationFiled: June 4, 2009Publication date: December 9, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Cristina Abucay Tan Hehir, Tiberiu Mircea Siclovan, Nicole Evelyn Barnhardt, Kenneth Michael Fish, Randall Lee Carter, Bruce Fletcher Johnson
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Publication number: 20100143258Abstract: In one aspect, the present invention provides a functionalized monodisperse polylysine comprising a linear monodisperse polylysine chain comprising constituent lysine monomer residues containing appended C4-C24 polyethylene glycol groups and at least one appended fluorescent dye moiety is provided.Type: ApplicationFiled: December 5, 2008Publication date: June 10, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Anup Sood, Jason William Castle, Evelina Roxana Loghin, Natalie Anne Staples, Kenneth Michael Fish, Randall Lee Carter, Brian Duh-Lan Lee, Kathleen Bove
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Patent number: 7651642Abstract: A composition comprises a polyorganosiloxane and an admixed hindered amine light stabilizer (HALS) wherein the polyorganosiloxane is free from alternating cyclic hydrocarbon residues. A method of stabilizing a polyorganosiloxane composition comprises providing a polyorganosiloxane and admixing a HALS with the polyorganosiloxane. A light bulb comprises an enclosure coated with a polyorganosiloxane composition containing a HALS.Type: GrantFiled: March 8, 2004Date of Patent: January 26, 2010Assignee: Momentive Performance Materials Inc.Inventors: Randall Lee Carter, Tricia Patrice Silverton, Robert J. Berki
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Patent number: 7273650Abstract: Substantially solvent-free multilayer articles characterized by excellent color retention and gloss retention, solvent resistance and recyclability comprise a substrate layer which may be at least one of polycarbonates, polyesters and ABS and ASA copolymers, and a resinous coating layer which contains resorcinol or alkylresorcinol isophthalate/terephthalate ester units. An intermediate layer may also be present.Type: GrantFiled: April 8, 2003Date of Patent: September 25, 2007Assignee: General Electric CompanyInventors: James Edward Pickett, Randall Lee Carter, Jimmy Lynn Webb, Daniel Robert Olson, Frank Axel Hoefflin, Hua Wang
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Publication number: 20040236010Abstract: A composition comprises a polyorganosiloxane and an admixed hindered amine light stabilizer (HALS) wherein the polyorganosiloxane is free from alternating cyclic hydrocarbon residues. A method of stabilizing a polyorganosiloxane composition comprises providing a polyorganosiloxane and admixing a HALS with the polyorganosiloxane. A light bulb comprises an enclosure coated with a polyorganosiloxane composition containing a HALS.Type: ApplicationFiled: March 8, 2004Publication date: November 25, 2004Inventors: Randall Lee Carter, Tricia Patrice Silverton, Robert J. Berki
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Publication number: 20030207096Abstract: Substantially solvent-free multilayer articles characterized by excellent color retention and gloss retention, solvent resistance and recyclability comprise a substrate layer which may be at least one of polycarbonates, polyesters and ABS and ASA copolymers, and a resinous coating layer which contains resorcinol or alkylresorcinol isophthalate/terephthalate ester units. An intermediate layer may also be present.Type: ApplicationFiled: April 8, 2003Publication date: November 6, 2003Inventors: James Edward Pickett, Randall Lee Carter, Jimmy Lynn Webb, Daniel Robert Olson, Frank Axel Hoefflin, Hua Wang
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Patent number: 6572956Abstract: Substantially solvent-free multilayer articles characterized by excellent color retention and gloss retention, solvent resistance and recyclability comprise a substrate layer comprising a first material selected from the group consisting of a metal, ceramic, glass, a cellulosic material, a thermoset resin, and a thermoplastic resin, and a resinous coating layer which comprises resorcinol or alkylresorcinol isophthalate/terephthalate ester units. An intermediate layer may also be present.Type: GrantFiled: August 5, 1999Date of Patent: June 3, 2003Assignee: General Electric CompanyInventors: James Edward Pickett, Randall Lee Carter, Jimmy Lynn Webb, Daniel Robert Olson, Frank Axel Hoefflin, Hua Wang
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Publication number: 20030082388Abstract: A composition comprises a polyorganosiloxane and an admixed hindered amine light stabilizer (HALS) wherein the polyorganosiloxane is free from alternating cyclic hydrocarbon residues. A method of stabilizing a polyorganosiloxane composition comprises providing a polyorganosiloxane and admixing a HALS with the polyorganosiloxane. A light bulb comprises an enclosure coated with a polyorganosiloxane composition containing a HALS.Type: ApplicationFiled: July 23, 2001Publication date: May 1, 2003Applicant: General Electric CompanyInventors: Randall Lee Carter, Tricia Patrice Silverton, Robert Joseph Berki
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Patent number: 6143839Abstract: Weatherability of polycarbonates, or of blends of polycarbonates with other polymers such as polyesters, is improved by incorporating therein a thermoplastic arylate polymer comprising units derived from a resorcinol or alkylresorcinol isophthalate-terephthalate. These units may be combined with units derived from a resorcinol or alkylresorcinol ester of a C.sub.4-12 aliphatic, alicyclic or mixed aliphatic-alicyclic dicarboxylic acid, such as sebacic acid.Type: GrantFiled: September 14, 1998Date of Patent: November 7, 2000Assignee: General Electric CompanyInventors: Jimmy Lynn Webb, Randall Lee Carter, Tiberiu Mircea Siclovan, James Edward Pickett
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Patent number: 6031033Abstract: Weatherable polycarbonate compositions (formulations or blends) comprise at least one of a piperazinone and piperazine dione based HALS, and polyether based. The combination of these HALS and polyether based polymers exhibits a synergy that results in enhanced protection of the polycarbonate compositions by imparting photostability to the polycarbonate formulations, thereby reducing yellowing or other forms of light induced degradation.Type: GrantFiled: November 25, 1997Date of Patent: February 29, 2000Assignee: General Electric CompanyInventors: James Edward Pickett, Randall Lee Carter
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Patent number: 5916997Abstract: Disclosed are weatherable polyester soft block copolymer compositions comprising copolymers of resorcinol or alternatively phenol, aromatic dicarboxylic acid, and a aliphatic dicarboxylic acid based structural units. These polyester soft block copolymers comprise a substantial proportion of direct linkages between the resorcinol or alternatively the phenol, and the aromatic dicarboxylic acid based structural units, the balance of the linkages being between resorcinol and the aliphatic dicarboxylic acid based structural units.Type: GrantFiled: February 25, 1998Date of Patent: June 29, 1999Assignee: General Electric CompanyInventors: Jimmy Lynn Webb, Randall Lee Carter, Tiberiu Mircca Siclovan, Matthew Hal Littlejohn, James Edward Pickett
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Patent number: 5907026Abstract: Weatherable polycarbonate compositions (formulations or blends) comprise polycarbonate, cycloaliphatic polyester resins, at least one of a benzotriazole, benzophenone, and triazine based UVA, and a catalyst quencher. The incorporation of the cycloaliphatic polyester resin and the benzotriazole, benzophenone, and triazine based UVA exhibits a synergistic effect, thereby resulting in unexpected enhanced protection of the polycarbonate compositions by imparting photostability to the polycarbonate formulations, thereby reducing yellowing or other forms of light induced degradation.Type: GrantFiled: August 27, 1997Date of Patent: May 25, 1999Assignee: General Electric CompanyInventors: Arnold Factor, Randall Lee Carter, Robert Russell Gallucci
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Patent number: 5869554Abstract: Weatherable polycarbonate compositions (formulations or blends) comprise at least one of a piperazinone and piperazine dione based HALS, and at least one of a benzotriazole, benzophenone, triazine, oxanilide, and cyanoacrylate based UVA. The combination of these HALS and UVA exhibits a synergy that results in enhanced protection of the polycarbonate compositions by imparting photostability to the polycarbonate formulations, thereby reducing yellowing or other forms of light induced degradation.Type: GrantFiled: September 2, 1997Date of Patent: February 9, 1999Assignee: General Electric CompanyInventors: James Edward Pickett, Randall Lee Carter