Patents by Inventor Randall Newton Toy

Randall Newton Toy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • APOE AND APOB MODIFIED LIPID NANOPARTICLE COMPOSITIONS AND USES THEREOF
    Publication number: 20240299580
    Abstract: Provided herein are pharmaceutical compositions comprising a lipid nanoparticle (LNP) and a therapeutic nucleic acid (TNA), wherein the LNP comprises an ApoE polypeptide, or a fragment thereof and/or an ApoB polypeptide, or a fragment thereof, linked to the LNP, and at least one pharmaceutically acceptable excipient. The ApoE polypeptide, or the fragment thereof, and/or the ApoB polypeptide, or the fragment thereof, are capable of binding a low-density lipoprotein (LDL) receptor, or LDL receptor family member, advantageously providing LNP compositions that can be directed to any cell or tissue expressing the LDL receptor.
    Type: Application
    Filed: June 7, 2022
    Publication date: September 12, 2024
    Inventors: Michelle LeBlanc, Gregory Feinstein, Randall Newton Toy, Birte Nolting, Nathaniel Silver, Phillip Samayoa, Jon Edward Chatterton, Matthew Manganiello, Douglas A. Rose, Ryan M. Delaney