Patents by Inventor Randall R. Miller

Randall R. Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS
    Publication number: 20220081403
    Abstract: The present invention discloses oxazolidinone compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A and E, are as defined herein. The present invention also relates to compositions which comprise at least one oxazolidinone compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of an oxazolidinone of the invention and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.
    Type: Application
    Filed: December 19, 2019
    Publication date: March 17, 2022
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Randall R. Miller, Joseph A. Kozlowski, Philippe Nantermet, David B. Olsen, Jing Su, Lihu Yang, Takao Suzuki, Brendan Crowley, Negxue Wang, Lanying You
  • Streptomyces sp. MA 7074 (ATCC 55605) used for microbial synthesis of HIV protease inhibitors
    Patent number: 5612217
    Abstract: Biotransformation products of a fermentation with culture MA7074 are potent HIV protease inhibitors. These products are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
    Type: Grant
    Filed: October 25, 1994
    Date of Patent: March 18, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Ali Shafiee, Shieh-Shung T. Chen, Byron H. Arison, Randall R. Miller, George M. Garrity, Brian Heimbuch
  • Microbial transformation product having immunosuppressive activity
    Patent number: 5352783
    Abstract: Microbial transformation of a macrolide immunosuppressant by the microorganism Streptomyces sp., (Merck Culture Collection MA 6960) ATCC No. 55387 yields a compound of the structural formula (I): ##STR1## This compound is an immunosuppressant useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases, the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
    Type: Grant
    Filed: June 9, 1993
    Date of Patent: October 4, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Ali Shafiee, Byron H. Arison, Shieh-Shung T. Chen, Randall R. Miller, Ralph A. Stearns