Patents by Inventor Randall R. Rossman

Randall R. Rossman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
    Patent number: 6214827
    Abstract: Novel compounds of Formula are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
    Type: Grant
    Filed: June 23, 1998
    Date of Patent: April 10, 2001
    Assignee: Schering Corporation
    Inventors: Adriano Afonso, John J. Baldwin, Ronald J. Doll, Ge Li, Alan K. Mallams, F. George Njoroge, Dinanath F. Rane, John C. Reader, Randall R. Rossman
  • Tricyclic compounds
    Patent number: 5891872
    Abstract: Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: April 6, 1999
    Assignee: Schering Corporation
    Inventors: Ronald J. Doll, Alan K. Mallams, Adriano Afonso, Dinanath F. Rane, F. George Njoroge, Randall R. Rossman
  • Carbonyl piperazinyl and piperidinyl compounds
    Patent number: 5880128
    Abstract: Novel carbonyl piperazinyl and piperidinyl compounds and pharmaceutical compositions are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel carbonyl piperazinyl or piperidinyl compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
    Type: Grant
    Filed: May 8, 1996
    Date of Patent: March 9, 1999
    Assignees: Schering Corporation, Pharmacopeia Inc.
    Inventors: Ronald J. Doll, Alan K. Mallams, Adriano Afonso, Dinanth F. Rane, George F. Njoroge, Randall R. Rossman, John J. Baldwin, Ge Li, John C. Reader
  • Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
    Patent number: 5801175
    Abstract: Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the above formula to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: September 1, 1998
    Assignees: Schering Corporation, Pharmacopeia, Inc.
    Inventors: Adriano Afonso, John J. Baldwin, Ronald J. Doll, Ge Li, Alan K. Mallams, F. George Njoroge, Dinanath F. Rane, John C. Reader, Randall R. Rossman
  • Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
    Patent number: 5712280
    Abstract: Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the Formula 1.0 to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: January 27, 1998
    Assignee: Schering Corporation
    Inventors: Ronald J. Doll, Alan K. Mallams, Adriano Afonso, Dinanath F. Rane, Randall R. Rossman, F. George Njoroge
  • Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
    Patent number: 5672611
    Abstract: Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the Formula 1.0 to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: September 30, 1997
    Assignee: Schering Corporation
    Inventors: Ronald J. Doll, Alan K. Mallams, Adriano Afonso, Dinanath F. Rane, Randall R. Rossman, F. George Njoroge
  • 3-O-glycosyl 16-membered macrolide antibacterials and related derivatives
    Patent number: 4962146
    Abstract: 3-O-Glycosyl derivatives of 16-membered macrolides such as O-.alpha.-L-cladinosyl-(1.fwdarw.3)-12,13-dehydro-12,13-deoxorosaramicin, 2", 4",4'"-tri-O-acetyl-O-(4'-O-phenoxyacetyl-.alpha.-L-cladinosyl)-(1.fwdarw. 3)-desmyconsin and pharmaceutically acceptable acid addition salts thereof useful as antibacterials are disclosed.
    Type: Grant
    Filed: October 14, 1988
    Date of Patent: October 9, 1990
    Assignee: Schering Corporation
    Inventors: Alan K. Mallams, Randall R. Rossman, Olga Sarre, Viyyoor M. Girijavallabhan, Ashit K. Ganguly
  • Di and tri-O-acetyl-"O-iso-valeryl-23-O-demycinosyl tylosins, hydrazone derivatives thereof and processes for their preparation
    Patent number: 4851518
    Abstract: There are disclosed novel di- and tri-O-acetyl-23-O-demycinosyl-4"-O-iso-valeryltylosins and the pharmaceutically acceptable salts thereof, which have improved activity as antibacterials and provide higher blood levels than other tylosin derived compounds. These compounds have the following structural formula ##STR1## wherein R is acetyl or hydrogen and z is for example O or ##STR2##Processes for selectively deacylating the 2' and 4"-positions of 3,2',4",4'"-tetra-O-acyltylosin or 2',4",4'"-tri-O-acyltylosin and for the selective acylation of 2',4"-di-O-acyltylosin and 2',4",4'"-tri-O-acyltylosin are also disclosed.
    Type: Grant
    Filed: December 23, 1985
    Date of Patent: July 25, 1989
    Assignee: Schering Corporation
    Inventors: Alan K. Mallams, Randall R. Rossman
  • 12,13-oxoderivatives of macrolides
    Patent number: 4808575
    Abstract: 12,13-Oxo derivatives of 16-membered macrolides such as tylosin and 23-O-demycinosyltylosin useful as antibacterials are disclosed.
    Type: Grant
    Filed: June 23, 1986
    Date of Patent: February 28, 1989
    Assignee: Schering Corporation
    Inventors: Alan K. Mallams, Randall R. Rossman