Abstract: A board-to-board connector assembly includes first and second connector assemblies and a connector interconnect between the first and second connector assemblies. Each connector assembly includes an outer shell and a connector received in a cavity of the outer shell. The connector has a connector body holding contacts in a card slot, which receives a circuit card edge of an add-in card. The outer shell has an outer board guide configured to engage the add-in card and guide mating of the outer shell with the add-in card. The outer shell has a latch configured to latchably engage the add-in card to secure the connector to the add-in card. The connector interposer electrically interconnects the contacts of the connector assemblies to electrically connect the add-in cards.

Abstract: A system for generating a model for predicting a molecular property of a variant of a molecule is provided. For each of a plurality of variants of the molecule, the system for each structural feature, aggregates the values for the structural features of the residues of the molecule that were modified to form the variant to form a feature vector for the variant. The system assigns the value for the molecular property of the variant to the feature vector wherein the feature vector and the assigned value form training data. The system then generates the model for predicting a value for the molecular property using the training data for the plurality of variants.

Abstract: Amino acid sequences of proteins can be produced using an autoencoder. For example, amino acid sequences of variant proteins can be produced by an autoencoder that is fed an amino acid sequence of a base protein as input. A decoding component of the autoencoder can include at least one or more components of a generative adversarial network.

Abstract: A cable connector module includes a cable card assembly including a circuit card, cables terminated to the circuit card, and a cable holder coupled to the circuit card and holding the cables relative to the circuit card. The cables include cable conductors electrically connected to corresponding cable contacts of the circuit card. The cable holder holds each of the contacts and includes a connecting tab coupled to the circuit card. The circuit card includes front and rear retaining tabs. The cable connector module includes a connector shell having a cavity that receives the cable card assembly. The connector shell includes a front retainer at the front receiving the front retaining tab to hold the front of the circuit card relative to the connector shell. The connector shell includes a rear retainer at the rear receiving the rear retaining tab to hold the rear of the circuit card relative to the connector shell.

Abstract: Amino acid sequences of proteins can be produced using one or more generative machine learning architectures. The amino acid sequences produced by the one or more generative machine learning architectures can be used to train a classification model architecture. The classification model architecture can classify amino acid sequences according to a number of classifications. Individual classifications of the number of classifications can correspond to at least one of a structural feature of proteins, a range of values of a structural feature of proteins, a biophysical property of proteins, or a range of values of a biophysical property of proteins.

Abstract: A plug connector includes a plug housing including a mating end and a cable end perpendicular to the mating end. The contact assembly includes an array of contacts each having a mating end and a terminating end. The contacts are right-angle contacts terminated to an end of a conductor of a cable. The plug connector includes a latch coupled to the plug housing. The latch includes a main body and a latch member extending from the main body. The main body has an actuator is configured to actuate the latch. The latch member includes a securing base coupled to the plug housing to secure the latch to the plug housing. The latch member includes a latching tab configured to be latchably coupled to the mating connector to secure the plug connector to the mating connector.

Abstract: A plug connector includes a plug housing including a mating end and a cable end. The cable end is oriented perpendicular to the mating end. The plug housing includes a mating chamber at the mating end and a cable chamber at the cable end. The plug connector includes a contact assembly coupled to the plug housing. The contact assembly includes an array of contacts. Each contact includes a mating end and a terminating end. Each contact is a right angle contact having the terminating end being perpendicular to the mating end. The plug connector includes cables terminated to the terminating ends of the contacts. Ends of the cables extend into the cable end of the plug housing. The cables extend from the plug housing at the cable end. The cables extend along linear cable axes from the contacts to the exterior of the plug housing.

Abstract: An electrical connector assembly includes a housing having a card slot at a mating end configured to pass through a panel opening of a panel forward of the panel for receiving a circuit card. A cable end of the housing is rearward of the panel. The electrical connector assembly includes contacts held in the housing. The electrical connector assembly includes cables terminated to the contacts and extending from the housing. The electrical connector assembly includes a connector mounting bracket having a collar surrounding a window receiving the housing. The connector mounting bracket has mounting latches extending from the collar with latch fingers configured to be coupled to the panel. The connector mounting bracket includes a biasing element configured to engage the panel to bias the panel against the mounting latches.

Abstract: Amino acid sequences of antibodies can be generated using a generative adversarial network that includes a first generating component that generates amino acid sequences of antibody light chains and a second generating component that generates amino acid sequences of antibody heavy chains. Amino acid sequences of antibodies call be produced by combining the respective amino acid sequences produced by the first generating component and the second generating component. The training of the first generating component and the second generating component can proceed at different rates. Additionally, the antibody amino acids produced by combining amino acid sequences front the first generating component and the second generating component may be evaluated according to complentarity-determining regions of the antibody amino acid sequences.

Abstract: Amino acid sequences of antibodies can be generated using a generative adversarial network that includes a first generating component that generates amino acid sequences of antibody light chains and a second generating component generates amino acid sequences of antibody heavy chains. Amino acid sequences of antibodies can be produced by combining the respective amino acid sequences produced by the first generating component and the second generating component. The training of the first generating component and the second generating component can proceed at different rates. Additionally, the antibody amino acids produced by combining amino acid sequences from the first generating component and the second generating component may be evaluated according to complentarity-determining regions of the antibody amino acid sequences.

Abstract: A board-to-board connector assembly includes first and second connector assemblies and a connector interconnect between the first and second connector assemblies. Each connector assembly includes an outer shell and a connector received in a cavity of the outer shell. The connector has a connector body holding contacts in a card slot, which receives a circuit card edge of an add-in card. The outer shell has an outer board guide configured to engage the add-in card and guide mating of the outer shell with the add-in card. The outer shell has a latch configured to latchably engage the add-in card to secure the connector to the add-in card. The connector interposer electrically interconnects the contacts of the connector assemblies to electrically connect the add-in cards.

Abstract: Systems and techniques are described to generate amino acid sequences of target proteins based on amino acid sequences of template proteins using machine learning techniques. The amino acid sequences of the target proteins can be generated based on data that constrains the modifications that can be made to the amino acid sequences of the template proteins. In illustrative examples, the template proteins can include antibodies produced by a non-human mammal that bind to an antigen and the target proteins can correspond to human antibodies with a region having at least a threshold amount of identity with the binding region of the template antibody. Generative adversarial networks can be used to produce the amino acid sequences of the target proteins.

Abstract: A communication system includes a plug connector mated with a receptacle connector. The receptacle connector includes a housing holding a contact assembly. The housing includes a front housing that receives an inner housing, which receives contact holders and receptacle contacts of the contact assembly. The receptacle connector housing includes a height profile defined between top and bottom walls with a housing latch and guide pockets contained within the height profile. The plug connector includes a housing holding a cable assembly with a circuit card received in a card slot of the receptacle housing. The plug connector housing includes alignment embossments received in the guide pockets and latches coupled to the alignment embossments are latchably coupled to the receptacle connector. The latches are contained within a height profile of the plug connector housing.

Abstract: An electrical connector assembly includes a housing having a card slot at a mating end configured to pass through a panel opening of a panel forward of the panel for receiving a circuit card. A cable end of the housing is rearward of the panel. The electrical connector assembly includes contacts held in the housing. The electrical connector assembly includes cables terminated to the contacts and extending from the housing. The electrical connector assembly includes a connector mounting bracket having a collar surrounding a window receiving the housing. The connector mounting bracket has mounting latches extending from the collar with latch fingers configured to be coupled to the panel. The connector mounting bracket includes a biasing element configured to engage the panel to bias the panel against the mounting latches.

Abstract: A receptacle coupler includes a coupler contact assembly having upper and lower contacts each having a front mating beam configured to mate with a front module circuit board and a rear mating beam configured to mate with a rear module circuit board with an intermediate portion therebetween. The coupler contact assembly includes a contact holder holding the upper and lower contacts. The receptacle coupler includes a coupler housing having a contact chamber receiving the coupler contact assembly and front and rear receptacles configured to receive the module circuit boards. The coupler housing holds the coupler contact assembly with the front mating beams in the front receptacle for mating with the front module circuit board and the rear mating beams in the rear receptacle for mating with the rear module circuit board.

Abstract: A receptacle connector includes a housing having a mating end for mating with a plug connector and a mounting end for mounting to a circuit board. The housing has side walls and end walls with contacts in contacts arrays along both side walls. The contacts have mating ends and terminating ends. The housing has a card slot open at the mating end for receiving plug connector defined by interior surfaces of the side walls. The mating ends of the contacts are exposed in the card slot for mating electrical connection with the plug connector. The housing has alignment tabs extending inward into the card slot from the interior surface for aligning the plug connector within the card slot.

Abstract: The concepts described herein are directed to implementations of production facilities that can produce molecules used to treat biological conditions, such as biotherapeutics. The biotherapeutics can include various molecules, such as proteins, enzymes, and antibodies. The production facilities can include a number of separate modular cleanrooms that comprise particular pieces of equipment to perform one or more aspects of the processes used to manufacture biotherapeutics. The modular cleanrooms are arranged such that material that is produced by the equipment of one modular cleanroom can be transferred to another modular cleanroom for additional processing. Additionally, systems and processes are described to generate models using machine learning techniques, where the models can be used to predict productivity and/or efficiency metrics for production lines of biotherapeutics. Further, models can be generated to control the operation of pieces of equipment included in the production lines.

Abstract: A plug connector assembly includes first and second plug connectors each including a plug housing having a top wall, a bottom wall, a first side wall, and a second side wall forming a cavity. The side walls include a housing securing feature. The plug connector assembly includes a flex jumper assembly coupled between the plug connectors having a flex circuit extending between first and second paddle cards. The paddle cards each include a rigid substrate having a mating end and side edges extending to a flex circuit end. The rigid substrate includes a plug connector securing feature at the side edge engaging the housing securing feature to retain the paddle card in the corresponding plug housing. The flex circuit is flexible between the first and second paddle cards.

Abstract: Amino acid sequences of antibodies can be generated using a generative adversarial network that includes a first generating component that generates amino acid sequences of antibody light chains and a second generating component generates amino acid sequences of antibody heavy chains. Amino acid sequences of antibodies can be produced by combining the respective amino acid sequences produced by the first generating component and the second generating component. The training of the first generating component and the second generating component can proceed at different rates. Additionally, the antibody amino acids produced by combining amino acid sequences from the first generating component and the second generating component may be evaluated according to complentarity-determining regions of the antibody amino acid sequences.

Abstract: This invention relates to the general field of recombinant expression of polypeptides in animal cell culture. More specifically, the invention concerns improved selection of cells transfected with recombinantly engineered vectors designed to express polypeptides, in particular heteromultimeric polypeptides.