Abstract: A track tension system including a hydraulic cylinder coupled between a drive frame and idler of a track system, an accumulator and a hydraulic valve that controls flow between the cylinder and accumulator. The cylinder extends and retracts to change the distance between the drive frame and idler which increases and decreases, respectively, tension on the track system. The hydraulic valve can be opened to allow flow between the cylinder and accumulator, and closed to block flow between the cylinder and accumulator. Control factors can be monitored to control valve position. An overload pressure relief can allow flow between the cylinder and accumulator when the hydraulic valve is closed and pressure in the cylinder reaches overload pressure. An orifice can allow constricted flow between the cylinder and accumulator when the hydraulic valve is closed. A check valve can connect the track tension system to a vehicle hydraulic system.

Abstract: The present invention provides a novel screening tool for the determination of compounds capable of promoting bone healing, promoting osteoblast cellular differentiation, improving bone mass or volume, and/or promoting osteogenesis that could be used in the treatment of various bone-loss or bone density decreasing disorders. The present invention also provides a screening tool for the determination of compounds capable of inhibiting osteoblast cellular differentiation, decreasing bone mass or volume, and/or inhibiting osteogenesis. Also provided are compositions and methods for the treatment of various bone-loss or bone density decreasing disorders.

Abstract: A method is provided for treating subjects, including humans, with infection or virulence by pathogens. The method involves administering an agent in amounts effective to eradicate or reduce infections and/or an inflammatory response caused by pathogens. Methods for identifying compounds useful as anti-infectives that decrease the immune resistance, virulence, or growth of microbes are also provided. More particularly, there are provided methods for identifying compounds which increase accumulation or stability or activity, or alternatively decrease the degradation of HIF-1a protein.

Abstract: Immunodeficient animals are generated by introducing a mutation in RAG-1 into the germline of the animals via gene targeting in embryonic stem cells. The production of mutant RAG-1 deficient mice is detailed. RAG-1 deficient mice have no mature B and T lymphocytes. The arrest of B and T cell differentiation occurs at an early stage and correlates with the inability to perform V(D)J recombination. To date, these mice do not have mature B and T lymphocytes, nor do they express immunoglobulin or T cell receptors. The same strategy can be applied to the generation of other RAG-1 deficient animals, such as rabbits, rats, and pigs, using known techniques. These animals are all useful for the same general purposes as the scid mice, for example, cultivation of human lymphocytes for expression of human immunoglobulin.

Abstract: A device and method are disclosed for conducting a reaction, such as an extraction reaction. The device is flexible and provides contained compartments with pre-incorporated liquids. The liquids are reliably moved past temporary barriers by constructing the barrier to be a relatively thin sheet that bursts preferentially compared to seals between the sheet and the rest of the material defining the compartments.

Abstract: Heat-softened glass sheets are shaped to either simple or compound bends while being continuously conveyed by means of forming rolls having transverse curvature, wherein, in at least the first portion of the bending station, the force of gravity alone causes the glass sheets to sag into substantial conformity with the transverse curvature of the forming rolls. Support for each glass sheet is gradually transferred from straight conveyor rolls to curved forming rolls without vertically reciprocating the rolls. Optionally, at the exit end of the forming station, a set of upper forming rolls having transverse curvature complementary to that of the lower forming rolls may be provided to assure close conformance to the desired curvature. Compound bends may be formed by providing the path defined by the lower forming rolls with a concave curvature in the direction of glass travel.

Abstract: This invention relates to shaping and quenching glass sheets by roll forming to either simple or compound curvatures comprising a longitudinal component of curvature about an axis of bending transverse to a path of movement by a controlled, repeatable program of roll forming without causing the glass sheets to stop their forward movement during their shaping. A series of glass sheets are heated and then rapidly cooled while conveyed along a path defined by a conveyor system comprising longitudinally spaced rotating rolls. The path includes a longitudinally curved portion that imparts a longitudinal component of curvature to the glass sheets after the latter are softened by heat.