Patents by Inventor Randall T. Irvin
Randall T. Irvin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9096775Abstract: The present invention relates to a methods and composition in which a D-form or retro-inverso Pseudomonas pilin peptide is bound to a substrate. The disclosed methods and composition are useful for inhibiting biofilm formation by non-Pseudomonas bacteria, for reducing the inflammatory response to a material, for reducing corrosion of metals, and in biosensor applications.Type: GrantFiled: April 14, 2011Date of Patent: August 4, 2015Assignee: Arch Biophysics, Inc.Inventors: Randall T. Irvin, Elisabeth M. Davis, DongYang Li, Daniel Abraham Muruve
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Patent number: 8961984Abstract: The present invention relates to a method for covalently attaching a compound to a stainless steel, tin, iron, or titanium substrate, by contacting exposed surface(s) of the substrate with a synthetic pilin peptide containing a disulfide loop derived from the C-terminal receptor binding protein of Type IV P. aeruginosa (T4P) pilin, to bind the pilin peptide to the exposed surface(s), and covalently attaching the compound to the pilin peptide. Also disclosed are a substrate formed by the method and a biosensor device that uses the uses. Also disclosed are methods for improving the corrosion resistance, adhesive force, hardness and electron work function of certain metals.Type: GrantFiled: October 7, 2010Date of Patent: February 24, 2015Assignee: Arch Biophysics, Inc.Inventors: Randall T. Irvin, Elisabeth M. Davis, DongYang Li
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Patent number: 8454977Abstract: The present invention relates to a composition, device and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.Type: GrantFiled: July 8, 2011Date of Patent: June 4, 2013Assignee: The Regents of the University of Colorado, a Body CorporateInventors: Robert S. Hodges, Randall T. Irvin, Carmen Giltner, Erin Van Schaik
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Patent number: 8354267Abstract: Transgenic microbes with an altered electrogenic efficacy, biofilms comprising such microbes, and microbial fuel cells comprising such microbes are provided. The microbial fuel cells can be operated as monitors, filtration devices, and sensors.Type: GrantFiled: February 23, 2010Date of Patent: January 15, 2013Assignees: Bacterial Robotics, LLC, University of CincinnatiInventors: Jason E. Barkeloo, Daniel J. Hassett, Randall T. Irvin
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Publication number: 20120016102Abstract: The present invention relates to a composition, device and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.Type: ApplicationFiled: July 8, 2011Publication date: January 19, 2012Applicants: UNIVERSITY OF ALBERTA, THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: Robert S. Hodges, Randall T. Irvin, Carmen Giltner, Erin Van Schaik
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Publication number: 20110293684Abstract: The present invention relates to a methods and composition in which a D-form or retro-inverso Pseudomonas pilin peptide is bound to a substrate. The disclosed methods and composition are useful for inhibiting biofilm formation by non-Pseudomonas bacteria, for reducing the inflammatory response to a material, for reducing corrosion of metals, and in biosensor applications.Type: ApplicationFiled: April 14, 2011Publication date: December 1, 2011Applicant: ARCH BIOPHYSICS, INC.Inventors: Randall T. Irvin, Elisabeth M. Davis, DongYang Li, Daniel Abraham Muruve
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Patent number: 7976851Abstract: The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.Type: GrantFiled: July 21, 2006Date of Patent: July 12, 2011Assignee: The Regents of the University of Colorado, A Body CorporateInventors: Robert S. Hodges, Randall T. Irvin, Carmen Giltner, Erin Van Schaik
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Publication number: 20110087321Abstract: The present invention relates to a method for covalently attaching a compound to a stainless steel, tin, iron, or titanium substrate, by contacting exposed surface(s) of the substrate with a synthetic pilin peptide containing a disulfide loop derived from the C-terminal receptor binding protein of Type IV P. aeruginosa (T4P) pilin, to bind the pilin peptide to the exposed surface(s), and covalently attaching the compound to the pilin peptide. Also disclosed are a substrate formed by the method and a biosensor device that uses the uses. Also disclosed are methods for improving the corrosion resistance, adhesive force, hardness and electron work function of certain metals.Type: ApplicationFiled: October 7, 2010Publication date: April 14, 2011Applicant: ARCH BIOPHYSICS, INC.Inventors: RANDALL T. IRVIN, ELISABETH M. DAVIS, DONGYANG LI
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Publication number: 20100297737Abstract: Transgenic microbes with an altered electrogenic efficacy, biofilms comprising such microbes, and microbial fuel cells comprising such microbes are provided. The microbial fuel cells can be operated as monitors, filtration devices, and sensors.Type: ApplicationFiled: February 23, 2010Publication date: November 25, 2010Inventors: JASON E. BARKELOO, DANIEL J. HASSETT, RANDALL T. IRVIN
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Publication number: 20100279178Abstract: Microbial fuel cells may include anode(s), cathode(s) and a biofilm attached to at least the anode. The biofilm may include bacterial cells adapted to facilitate transfer of a plurality of electrons to the anode from a feedstock. In an example embodiment, a microbial fuel surface may include a large surface area to volume ratio in order to increase power (electron) generation and/or transfer.Type: ApplicationFiled: February 23, 2010Publication date: November 4, 2010Inventors: Jason E. Barkeloo, Daniel J. Hassett, Randall T. Irvin
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Publication number: 20080287367Abstract: The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.Type: ApplicationFiled: July 21, 2006Publication date: November 20, 2008Applicants: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, UNIVERSITY OF ALBERTAInventors: Robert S. Hodges, Randall T. Irvin, Carmen Giltner, Erin Van Schaik
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Patent number: 7262272Abstract: The invention relates to the use of constrained coiled-coil polypeptides to mimic ?-helical structural elements of native proteins. These constrained peptidyl mimetics are used to generate and/or identify ligands which selectively bind the ?-helical segment contained in the native protein.Type: GrantFiled: February 15, 2005Date of Patent: August 28, 2007Assignee: The Governors of the University of AlbertaInventors: Leslie H. Kondejewski, Randall T. Irvin, Robert S. Hodges
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Patent number: 6872806Abstract: The invention relates to the use of constrained coiled-coil polypeptides to mimic ?-helical structural elements of native proteins. These constrained peptidyl mimetics are used to generate and/or identify ligands, which selectively bind the ?-helical segment contained in the native protein.Type: GrantFiled: June 26, 2000Date of Patent: March 29, 2005Assignee: The Governors of the University of AlbertaInventors: Leslie H. Kondejewski, Randall T. Irvin, Robert S. Hodges
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Patent number: 6767545Abstract: A composition and method for treating or preventing infection by Pseudomonas aeruginosa is disclosed. The composition includes a P. aeruginosa pilin peptide modified to prevent oligomerization of the pilin. The method involves administered the composition to a person infected with Pseudomonas are at risk of such infection.Type: GrantFiled: May 24, 2001Date of Patent: July 27, 2004Assignee: Governors of the University of AlbertaInventors: Randall T. Irvin, Randy J. Read, Bart Hazes, Wah Y. Wong, Sastry A. Parimi, Linda M. G. Glasier
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Publication number: 20030211114Abstract: A C-terminal pilin peptide vaccine for immunizing or treating a patient for infection by a Pseudomonas aeruginosa (PA) infection is disclosed. The peptide comprises the peptide identified as SEQ ID NOS. 3-6; and a carrier protein conjugated to the peptide. Also disclosed is a pilin peptide C-terminal PA pilin peptide having the amino acid sequence identified as SEQ ID NO: 3, and analogs thereof having one of residues T, K, or A at position 130, D, T, or N at position 132, Q, A, or V at position 133, E, P, N, or A at position 135, Q, M, or K at position 136, and I, T, L, or R at position 138, excluding SEQ ID NOS: 1, 2, 9, 10, and 11, and the ability to cross-react with antibodies against the corresponding C-terminal peptides from PA strains PAK and PAO.Type: ApplicationFiled: January 14, 2003Publication date: November 13, 2003Inventors: Robert S. Hodges, Randall T. Irvin, Paul J. Cachia
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Patent number: 6541007Abstract: A C-terminal pilin peptide vaccine for immunizing or treating a patient for infection by a Pseudomonas aeruginosa (PA) infection is disclosed. The peptide comprises the peptide identified as SEQ ID NOS. 3-6; and a carrier protein conjugated to the peptide. Also disclosed is a pilin peptide C-terminal PA pilin peptide having the amino acid sequence identified as SEQ ID NO:3, and analogs thereof having one of residues T, K, or A at position 130, D, T, or N at position 132, Q, A, or V at position 133, E, P, N, or A at position 135, Q, M, or K at position 136, and I, T, L, or R at position 138, excluding SEQ ID NOS: 1, 2, 9, 10, and 11, and the ability to cross-react with antibodies against the corresponding C-terminal peptides from PA strains PAK and PAO.Type: GrantFiled: June 30, 1999Date of Patent: April 1, 2003Assignee: The Governors of the University of AlbertaInventors: Robert S. Hodges, Randall T. Irvin, Paul J. Cachia
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Patent number: 6478939Abstract: A biosensor apparatus for detecting a binding event between a ligand and receptor. The apparatus includes a biosensor surface and surface-bound two-subunit heterodimer complexes composed of first and second, preferably oppositely charged peptides that together form an &agr;-helical coiled-coil heterodimer. The first peptide is attached to the biosensor surface, and the second peptide carries the ligand, accessible for binding by a ligand-binding agent. Binding of anti-ligand binding agent to the surface-bound ligand is detected by a suitable detector. A ligand-specific biosensor surface can be readily prepared from a universal template containing the first charged peptide, by addition of a selected ligand attached to the second peptide.Type: GrantFiled: May 24, 2000Date of Patent: November 12, 2002Assignees: Pence, Inc., McGill UniversityInventors: R. Bruce Lennox, Robert S. Hodges, Randall T. Irvin
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Patent number: 6461490Abstract: A biosensor apparatus for detecting a binding event between a ligand and receptor. The apparatus includes a biosensor surface and surface-bound two-subunit heterodimer complexes composed of first and second, preferably oppositely charged peptides that together form an &agr;-helical coiled-coil heterodimer. The-first peptide is attached to the biosensor surface, and the second peptide carries the ligand, accessible for binding by a ligand-binding agent. Binding of anti-ligand binding agent to the surface-bound ligand is detected by a suitable detector. A ligand-specific biosensor surface can be readily prepared from a universal template containing the first charged peptide, by addition of a selected ligand attached to the second peptide.Type: GrantFiled: July 27, 2000Date of Patent: October 8, 2002Assignees: PENCE, Inc., McGill UniversityInventors: R. Bruce Lennox, Robert S. Hodges, Randall T. Irvin
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Publication number: 20020098196Abstract: A composition and method for treating or preventing infection by Pseudomonas aeruginosa is disclosed. The composition includes a P. aeruginosa pilin peptide modified to prevent oligomerization of the pilin. The method involves administered the composition to a person infected with Pseudomonas are at risk of such infection.Type: ApplicationFiled: May 24, 2001Publication date: July 25, 2002Inventors: Randall T. Irvin, Randy J. Read, Bart Hazes, Wah Y. Wong, Sastry A. Parimi, Linda M. G. Glasier
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Patent number: 6342233Abstract: A composition and method for treating or preventing infection by Pseudomonas aeruginosa is disclosed. The composition includes a P. aeruginosa pilin peptide modified to prevent oligomerization of the pilin. The method involves administered the composition to a person infected with Pseudomonas are at risk of such infection.Type: GrantFiled: June 11, 1999Date of Patent: January 29, 2002Assignee: Governors of the University of AlbertaInventors: Randall T. Irvin, Randy J. Read, Bart Hazes, Wah Y. Wong, Sastry A. Parimi, Linda M. G. Glasier