Patents by Inventor Randall T. Moon

Randall T. Moon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hedgehog-derived polypeptides
    Patent number: 6281332
    Abstract: The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G↓CF site recognized by the autoproteolytic domain in the native protein. Also provided are methods of use of the N and C fragments.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: August 28, 2001
    Assignee: The Johns Hopkins University School of Medicine
    Inventors: Philip A. Beachy, Randall T. Moon
  • Method of using hedgehog polypeptides to regulate neuronal cell growth
    Patent number: 6214794
    Abstract: The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a Gly↓Cys Phe site recognized by the autoproteolytic domain in the native protein. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described. Also provided are methods of use of the N and C fragments.
    Type: Grant
    Filed: October 7, 1996
    Date of Patent: April 10, 2001
    Assignees: The Johns Hopkins University School of Medicine, University of Washington
    Inventors: Philip A. Beachy, Randall T. Moon, Jeffrey A. Porter
  • Hedgehog-derived polypeptides
    Patent number: 6132728
    Abstract: The present invention provides two novel polypeptides, referred to as the "N" and "C" fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G.sup..dwnarw. CF site recognized by the autoproteolytic domain in the native protein. Also provided are methods of use of the N and C fragments.
    Type: Grant
    Filed: December 4, 1995
    Date of Patent: October 17, 2000
    Assignees: The Johns Hopkins University School of Medicine, University of Washington
    Inventors: Philip A. Beachy, Randall T. Moon, Jeffrey A. Porter