Patents by Inventor Randall T. Sparks

Randall T. Sparks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Controlled release pharmaceutical formulation
    Patent number: 5505962
    Abstract: An improved controlled release tablet formulation for the release of potassium chloride through a differentially permeable membrane from which the release of potassium chloride can be accurately controlled to minimize the likelihood of producing high localized concentrations of potassium within the gastrointestinal tract.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: April 9, 1996
    Assignee: Elan Corporation, plc
    Inventor: Randall T. Sparks
  • Controlled release powder and process for its preparation
    Patent number: 5354556
    Abstract: A controlled release powder containing discrete micro-particles for use in edible, pharmaceutical and other controlled release compositions is disclosed. The micro-particles have an average size in the range of from 0.1 to 125 .mu.m. Each of the micro-particles is in the form of a micromatrix of an active ingredient uniformly distributed in at least one non-toxic polymer. The micro-particles have a predetermined release of active ingredient when the dissolution rate thereof is measured according to the Paddle Method of U.S. Pharmacopoeia XX at 37.degree. C. and 75 r.p.m.
    Type: Grant
    Filed: July 9, 1990
    Date of Patent: October 11, 1994
    Assignee: Elan Corporation, plc
    Inventors: Randall T. Sparks, Edward J. Geoghegan
  • Sustained release drug delivery system
    Patent number: 5128142
    Abstract: A controlled release formulation comprising an adsorbate of a mixture of a pharmaceutically useful active ingredient and an inactive substance adsorbed on a cross-linked polymer. The inactive substance is selected to modify the dissolution of the active ingredient from the cross-linked polymer in vivo.
    Type: Grant
    Filed: August 17, 1989
    Date of Patent: July 7, 1992
    Assignee: Elan Corporation, plc
    Inventors: Seamus Mulligan, Randall T. Sparks
  • Sustained release capsule or tablet formulation comprising a pharmaceutically acceptable dihydropyridine
    Patent number: 5015479
    Abstract: A sustained release capsule or tablet formulation suitable for once-daily administration comprises an adsorbate of a mixture of a pharmaceutically useful dihydropyridine and a polyvinylpyrrolidone having an average-molecular weight greater than 55,000 adsorbed on a cross-linked polyvinylpyrrolidone and blended with a polymer or mixture of polymers which gel in the presence of water, the amount of said polymer or polymers being effective to produce the desired sustained release effect.
    Type: Grant
    Filed: September 30, 1988
    Date of Patent: May 14, 1991
    Inventors: Seamus Mulligan, Randall T. Sparks
  • Drug delivery system
    Patent number: 4973469
    Abstract: A controlled release formulation comprising an adsorbate of a mixture of a pharmaceutically useful active ingredient and an inactive substance adsorbed on a cross-linked polymer. The inactive substance is selected to modify the dissolution of the active ingredient from the cross-linked polymer in vivo.
    Type: Grant
    Filed: August 17, 1989
    Date of Patent: November 27, 1990
    Assignee: Elan Corporation, PLC
    Inventors: Seamus Mulligan, Randall T. Sparks
  • Controlled release powder and process for its preparation
    Patent number: 4952402
    Abstract: A controlled release powder containing discrete micro-particles for use in edible, pharmaceutical and other controlled release compositions is disclosed. The micro-particles have an average size in the range of from 0.1 to 125 .mu.m. Each of the micro-particles is in the form of a micromatrix of an active ingredient uniformly distributed in at least one non-toxic polymer. The micro-particles have a predetermined release of active ingedient when the dissolution rate thereof is measured according to the Paddle Method of U.S. Pharmacopoeia XX at 37.degree. C. and 75 r.p.m.
    Type: Grant
    Filed: March 17, 1988
    Date of Patent: August 28, 1990
    Assignee: Elan Corporation, p.l.c.
    Inventors: Randall T. Sparks, Edward J. Geoghegan
  • Controlled release powder and process for its preparation
    Patent number: 4940588
    Abstract: A controlled release powder containing discrete micro-particles for use in edible, pharmaceutical and other controlled release compositions is disclosed. The micro-particles have an average size in the range of from 0.1 to 125 .mu.m. Each of the micro-particles is in the form of a micromatrix of an active ingredient uniformly distributed in at least one non-toxic polymer. The micro-particles have a predetermined release of active ingredient when the dissolution rate thereof is measured according to the Paddle Method of U.S. Pharmacopoeia XX at 37.degree. C. and 75 r.p.m.
    Type: Grant
    Filed: March 17, 1988
    Date of Patent: July 10, 1990
    Assignee: Elan Corporation
    Inventors: Randall T. Sparks, Edward J. Geoghegan