Abstract: This invention is for a catheter apparatus that greatly reduces microbial infections resulting from catheterization of dialysis, semi-mobile, or hospitalized patients. The apparatus applies light in the ultraviolet and near ultraviolet band to multiple catheter lumens for both detection and inactivation of biofilm microorganisms. It uses real-time automated techniques for the selection of wavelength, power level and exposure time regimes that are used for irradiating the biofilm in vivo. Artificial intelligence is incorporated to adjust the UV irradiation regimes to maximize the microorganism inactivation efficacy while minimizing the destruction of keratinocytes. The biofilm inactivation efficacy of this infection resistant catheter apparatus is at least 99%. The apparatus allows for minimal deviation from conventional catheter insertion procedures and can remain in vivo for long periods of time without the risk of microorganism contamination.