Patents by Inventor Randall Wilber Barton

Randall Wilber Barton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR IMPROVING CELL LINE ACTIVITY IN IMMUNOISOLATION DEVICES
    Publication number: 20090110669
    Abstract: Methods for maintaining and improving the secretory activity of cells housed in immunoisolation devices.
    Type: Application
    Filed: January 5, 2009
    Publication date: April 30, 2009
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Richard Schneiderman, Revati J. Tatake, Randall Wilber Barton
  • Nucleic acid constructs useful for glucose regulated production of human insulin in somatic cell lines
    Patent number: 7045346
    Abstract: Unique multifunctional nucleotide expression cassettes comprising a nucleotide sequence encoding a human protease driven by a glucose-regulatable promoter, a nucleotide sequence encoding human proinsulin having sites at its B-C and C-A junctions altered to permit cleavage by the human protease, and a CMV promoter driving the transcription of the nucleotide sequence encoding the human proinsulin, such cassettes optionally having polyadenylation sequences after each structural gene and the nucleotide sequence encoding human proinsulin optionally carrying an H10D variant, and cells transformed thereby.
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: May 16, 2006
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Revati J. Tatake, Richard Schneiderman, Randall Wilber Barton
  • Nucleic acid constructs useful for glucose regulated production of human insulin in somatic cell lines
    Publication number: 20030032144
    Abstract: Unique multifunctional nucleotide expression cassettes comprising a nucleotide sequence encoding a human protease driven by a glucose-regulatable promoter, a nucleotide sequence encoding human proinsulin having sites at its B-C and C-A junctions altered to permit cleavage by the human protease, and a CMV promoter driving the transcription of the nucleotide sequence encoding the human proinsulin, such cassettes optionally having polyadenylation sequences after each structural gene and the nucleotide sequence encoding human proinsulin optionally carrying an H10D variant, and cells transformed thereby.
    Type: Application
    Filed: June 10, 2002
    Publication date: February 13, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Revati J. Tatake, Richard Schneiderman, Randall Wilber Barton
  • Methods for improving cell line activity in immunoisolation devices
    Publication number: 20030012772
    Abstract: Methods for maintaining and improving the secretory activity of cells housed in immunoisolation devices.
    Type: Application
    Filed: June 10, 2002
    Publication date: January 16, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Richard Schneiderman, Revati J. Tatake, Randall Wilber Barton