Patents by Inventor Randel Dorian
Randel Dorian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8328024Abstract: A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.Type: GrantFiled: August 4, 2011Date of Patent: December 11, 2012Assignees: Hanuman, LLC, Biomet Biologics, LLCInventors: Michael D. Leach, Randel Dorian, Jacy C. Hoeppner
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Publication number: 20120230890Abstract: A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.Type: ApplicationFiled: May 25, 2012Publication date: September 13, 2012Applicant: Hanuman LLCInventors: Randel Dorian, Scott R. King, Richard W. Storrs
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Publication number: 20120145652Abstract: A separator system operable to use centrifugation to fractionate a multiple component material, such as a suspension including blood, comprises a buoy. The buoy can be carried in a separation container and has a tuned density that is configured to reach an equilibrium position in the multiple component material. A guide surface is carried on a buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.Type: ApplicationFiled: February 20, 2012Publication date: June 14, 2012Applicants: Hanuman LLC, Biomet Biologics, LLCInventors: Michael D. Leach, Randel Dorian, Jacy C. Hoeppner
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Patent number: 8187477Abstract: A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.Type: GrantFiled: November 22, 2010Date of Patent: May 29, 2012Assignees: Hanuman, LLC, Biomet Biologics, LLCInventors: Randel Dorian, Scott R. King, Richard W. Storrs
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Patent number: 8133389Abstract: The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.Type: GrantFiled: July 29, 2011Date of Patent: March 13, 2012Assignees: Hanuman, LLC, Biomet Biologics, LLCInventors: Randel Dorian, Michael D. Leach
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Patent number: 8119013Abstract: A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.Type: GrantFiled: October 4, 2010Date of Patent: February 21, 2012Assignees: Hanuman, LLC, Biomet Biologics, LLCInventors: Michael D. Leach, Randel Dorian, Jacy C. Hoeppner
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Publication number: 20120027746Abstract: Methods of generating thrombin and methods of applying a clotting tissue sealant to a site on a subject are provided. A blood component comprising platelets can be obtained from the subject. A hypotonic composition is contacted with a solid matrix to form a thrombin-containing liquid, where the hypotonic composition includes water, calcium, a blood component comprising platelets, and optionally a chelator. Calcium is present in the hypotonic composition in an amount greater than the amount of calcium that can be complexed by the chelator. Thrombin-containing liquid is then separated from the hypotonic composition and can be applied to the site on the subject to form a clot, for example, by combination with fibrinogen.Type: ApplicationFiled: July 30, 2010Publication date: February 2, 2012Applicant: Biomet Biologics, LLCInventors: Randel DORIAN, Richard W. Storrs, Michael D. Leach
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Patent number: 8105495Abstract: A process for separating platelet rich plasma from a blood sample using a platelet rich plasma separator system is disclosed. The system includes an inner wall having a top edge and a central axis that is surrounded by a depth filter having a capacity to receive all of the erythrocytes in the blood sample, where an inner surface of the inner wall has an angle of about 0.2° from the central axis of the inner wall. The process includes spinning the inner cylinder at its central axis at a speed that separates the erythrocytes from plasma and platelets and causes the erythrocytes to collect against an inner surface of the depth filter. The cylinder is continually spun for a sufficient time to allow substantially all of the erythrocytes to flow up the inner surface and over the top edge into the depth filter, leaving platelet enriched plasma (PRP) in the inner cylinder, such that upon discontinuing the spinning, permits the platelet enriched plasma to flow to the bottom of the inner cylinder.Type: GrantFiled: January 10, 2011Date of Patent: January 31, 2012Assignees: Hanuman, LLC, Biomet Biologics, LLCInventors: Randel Dorian, Michael D. Leach
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Patent number: 8096422Abstract: Disclosed is a separator-concentrator, such as for separating and concentrating platelet-rich-plasma (PRP) from whole blood that is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly and a concentrator assembly. The centrifugal separation assembly comprises a centrifugal drum separator and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate.Type: GrantFiled: November 1, 2010Date of Patent: January 17, 2012Assignees: Hanuman LLC, Biomet Biologics, LLCInventors: Randel Dorian, Michael D. Leach
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Publication number: 20110284460Abstract: A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.Type: ApplicationFiled: August 4, 2011Publication date: November 24, 2011Applicants: Hanuman LLC, Biomet Biologics, LLCInventors: Michael D. Leach, Randel Dorian, Jacy C. Hoeppner
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Publication number: 20110281714Abstract: The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.Type: ApplicationFiled: July 29, 2011Publication date: November 17, 2011Applicants: Biomet Biologics, LLC, Hanuman LLCInventors: Randel Dorian, Michael D. Leach
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Patent number: 7992725Abstract: A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.Type: GrantFiled: April 11, 2008Date of Patent: August 9, 2011Assignee: Biomet Biologics, LLCInventors: Michael D. Leach, Randel Dorian, Jacy C. Hoeppner
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Patent number: 7987995Abstract: The PRP separator-concentrator of this invention is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly, and a concentrator assembly. The centrifugal separator assembly comprises a centrifugal drum separator that includes an erythrocyte capture module and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate. The centrifugal drum separator has an erythrocyte trap. The water removal module can be a syringe device with water absorbing beads or it can be a pump-hollow fiber cartridge assembly. The hollow fibers are membranes with pores that allow the flow of water through the fiber membrane while excluding flow of clotting factors useful for sealing and adhering tissue and growth factors helpful for healing while avoiding activation of platelets and disruption of any trace erythrocytes present in the PRP.Type: GrantFiled: May 3, 2010Date of Patent: August 2, 2011Assignees: Hanuman, LLC, Biomet Biologics, LLCInventors: Randel Dorian, Michael D. Leach
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Publication number: 20110100919Abstract: A process for separating platelet rich plasma from a blood sample using a platelet rich plasma separator system is disclosed. The system includes an inner wall having a top edge and a central axis that is surrounded by a depth filter having a capacity to receive all of the erythrocytes in the blood sample, where an inner surface of the inner wall has an angle of about 0.2° from the central axis of the inner wall. The process includes spinning the inner cylinder at its central axis at a speed that separates the erythrocytes from plasma and platelets and causes the erythrocytes to collect against an inner surface of the depth filter. The cylinder is continually spun for a sufficient time to allow substantially all of the erythrocytes to flow up the inner surface and over the top edge into the depth filter, leaving platelet enriched plasma (PRP) in the inner cylinder, such that upon discontinuing the spinning, permits the platelet enriched plasma to flow to the bottom of the inner cylinder.Type: ApplicationFiled: January 10, 2011Publication date: May 5, 2011Applicants: Hanuman LLC, Biomet Biologics, LLCInventors: Randel Dorian, Michael D. Leach
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Publication number: 20110065183Abstract: A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.Type: ApplicationFiled: November 22, 2010Publication date: March 17, 2011Applicant: Hanuman LLCInventors: Randel Dorian, Scott R. King, Richard Wood Storrs
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Patent number: 7901584Abstract: A plasma concentrator having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. A filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. A method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.Type: GrantFiled: June 2, 2009Date of Patent: March 8, 2011Assignees: Hanuman, LLC, Biomet BiologicsInventors: Randel Dorian, Michael D. Leach, Richard W. Storrs
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Publication number: 20110042296Abstract: Disclosed is a separator-concentrator, such as for separating and concentrating platelet-rich-plasma (PRP) from whole blood that is suitable for office use or emergency use for trauma victims. The PRP separator comprises a motorized centrifugal separation assembly and a concentrator assembly. The centrifugal separation assembly comprises a centrifugal drum separator and a motor having a drive axis connected to the centrifugal drum separator. The concentrator assembly comprises a water-removal module for preparing PRP concentrate.Type: ApplicationFiled: November 1, 2010Publication date: February 24, 2011Applicants: Hanuman LLC, Biomet Biologics, Inc.Inventors: Randel Dorian, Michael D. Leach
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Publication number: 20110021334Abstract: A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.Type: ApplicationFiled: October 4, 2010Publication date: January 27, 2011Applicants: Biomet Biologics, LLC, Hanuman LLCInventors: Michael D. Leach, Randel Dorian, Jacy C. Hoeppner
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Patent number: 7866485Abstract: A Platelet Rich Plasma separator assembly is disclosed. The assembly can include a cylindrical outer wall closed at the top by an upper plate and closed at the bottom. A bottom plate having an upper surface sloped down to a central opening. The top edge of the inner wall terminates at a distance from the upper plate to define an annular erythrocyte passageway therebetween. The inner wall has an outer surface and an inner surface that slopes radially inward from its top edge to its bottom at an angle of from 0.2 to 5 degrees with a central axis of the inner wall. A cylindrical depth filter is positioned between the inner surface of the outer wall and the outer surface of the inner wall in communication with the inner wall through the erythrocyte passageway.Type: GrantFiled: July 31, 2007Date of Patent: January 11, 2011Assignees: Hanuman, LLC, Biomet Biologics, LLCInventors: Randel Dorian, Michael D. Leach
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Patent number: 7837884Abstract: A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.Type: GrantFiled: December 29, 2008Date of Patent: November 23, 2010Assignee: Hanuman, LLCInventors: Randel Dorian, Scott R. King, Richard Wood Storrs