Abstract: The invention provides mammalian cDNAs which encode Xin-related proteins. It also provides for the use of the cDNAs, fragments, and complements thereof and of the encoded proteins, portions thereof and antibodies thereto for diagnosis and treatment of cardiac and skeletal muscle disorders, particularly hypertrophic cardiomyopathy, and for monitoring cardiac and skeletal muscle morphogenesis and development. The invention additionally provides expression vectors and host cells for the production of the proteins.

Abstract: The invention provides polynucleotides that encode SPARC-related proteins. It also provides for the use of the polynucleotide, protein, and antibodies thereto for diagnosis and treatment of atherosclerosis and cell proliferative disorders. The invention additionally provides methods for using the polynucleotides, proteins and antibodies.

Abstract: The invention provides polynucleotides that encode SPARC-related proteins. It also provides for the use of the polynucleotide, protein, and antibodies thereto for diagnosis and treatment of atherosclerosis and cell proliferative disorders. The invention additionally provides methods for using the polynucleotides, proteins and antibodies.

Abstract: The invention provides a Ras association domain containing protein, its encoding mammalian cDNA, and an antibody that specifically binds the protein. It also provides for the use of the cDNAs, complements, and variants thereof and of the protein, portions thereof and antibodies thereto to diagnose, stage, treat or monitor the progression or treatment of cell proliferative and inflammatory disorders.

Abstract: The invention provides polynucleotides that are specifically and differentially expressed in ovarian cancer, particularly serous papillary carcinoma. The invention also provides compositions, probes, expression vectors, host cells, proteins encoded by the polynucleotides and antibodies which specifically bind the proteins. The invention also provides methods for the diagnosis, prognosis and treatment of ovarian cancer.

Abstract: The invention provides a cDNA which encodes a colon cancer marker. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of colon disorders, particularly colon cancer and polyps. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

Abstract: The invention provides mammalian cDNAs which encode mammalian SPARC-related proteins. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of atherosclerosis and cell proliferative disorders. The invention additionally provides expression vectors and host cells for the production of the proteins and transgenic model systems.

Abstract: The invention provides a mammalian cDNA which encodes a mammalian Ras association domain containing protein. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of cell proliferative and inflammatory disorders, particularly thymus hyperplasia, allergies, asthma, and hypereosinophilia. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

Abstract: The invention provides cDNAs which encode ASIP-related proteins. It also provides for the use of the cDNAs, fragments, complements, and variants thereof and of the encoded proteins, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly bladder transitional cell carcinoma. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

Abstract: The invention provides cDNAs which encode mammalian intestinal proteins. It also provides for the use of the cDNAs, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of colon disorders, particularly colon cancer, Crohn's disease, and ulcerative colitis. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.

Abstract: The invention provides a cDNA which encodes a colon cancer marker. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of colon disorders, particularly colon cancer and polyps. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.