Patents by Inventor Randi Isaacs

Randi Isaacs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPIES OF EGFRVIII CHIMERIC ANTIGEN RECEPTORS AND PD-1 INHIBITORS
    Publication number: 20220088075
    Abstract: Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., EGFRvIII, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., EGFRvIII, in combination with a PD-1 inhibitor.
    Type: Application
    Filed: February 21, 2020
    Publication date: March 24, 2022
    Inventors: Donald M. O'Rourke, Stephen Joseph Bagley, Randi Isaacs, Arati Suvas Desai
  • CD19 CHIMERIC ANTIGEN RECEPTOR (CAR) AND CD22 CAR COMBINATION THERAPIES
    Publication number: 20210347851
    Abstract: The invention provides compositions and methods for treating cancer, e.g., hematological cancer, by administering a CD19 CAR-expressing cell as described herein, in combination with a CD22 CAR-expressing cell as described herein.
    Type: Application
    Filed: September 27, 2019
    Publication date: November 11, 2021
    Inventors: Randi Isaacs, Noelle Frey, David L. Porter
  • COMBINATION THERAPY WITH CHIMERIC ANTIGEN RECEPTOR (CAR) THERAPIES
    Publication number: 20210213063
    Abstract: The invention provides a method of treating an adult subject having a hematological cancer, comprising administering to the subject selected dosage regimens comprising a plurality of immune effector cells expressing a CAR molecule in combination with a BTK inhibitor.
    Type: Application
    Filed: May 24, 2019
    Publication date: July 15, 2021
    Applicants: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Randi Isaacs, K. Gary J. Vanasse, Eric Bleickardt, Saar Gill, Marco Ruella, Nathan Amar Singh, Elena Orlando
  • COMBINATION THERAPIES OF CHIMERIC ANTIGEN RECEPTORS AND PD-1 INHIBITORS
    Publication number: 20190151365
    Abstract: Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.
    Type: Application
    Filed: July 28, 2017
    Publication date: May 23, 2019
    Applicants: Novartis AG, The Trustees of the University of Pennsylvania, The Trustees of the University of Pennsylvania
    Inventors: Oezlem Anak, Sanela Bilic, Jennifer Brogdon, John Scott Cameron, William Chou, Stephan Grupp, Danny Roland Howard, Jr., Randi Isaacs, Carl H. June, Simon Lacey, Shannon Maude, Jan J. Melenhorst, Stephen Shuster, Alfonso Quintas-Cardama