Patents by Inventor Rando Allikmets

Rando Allikmets has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protective Complement Proteins and Age-Related Macular Degeneration
    Publication number: 20100273720
    Abstract: Methods for identifying a subject at risk for developing AMD are disclosed. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material. Therapeutic compositions and methods are also provided for delaying the progression or onset of the development of AMD in a subject, including treating a subject having signs and/or symptoms of AMD or who has been diagnosed with AMD.
    Type: Application
    Filed: December 22, 2009
    Publication date: October 28, 2010
    Applicants: University of lowa Research Foundation, The Trustees of Columbia University in The City of New York, National Institutes of Health Office of Technology Transfer
    Inventors: Gregory S. Hageman, Rando Allikmets, Michael C. Dean, Albert M. Gold
  • Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter
    Publication number: 20090029930
    Abstract: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
    Type: Application
    Filed: December 11, 2006
    Publication date: January 29, 2009
    Applicants: Utah, University of, Research Foundation, Johns Hopkins University, Baylor College of Medicine, United States of America Department of Health and Human Services
    Inventors: Rando Allikmets, Kent L. Anderson, Michael Dean, Mark Leppert, Richard A. Lewis, Yixin Li, James R. Lupski, Jeremy Nathans, Amir Rattner, Noah F. Shroyer, Nanda Singh, Philip Smallwood, Hui Sun
  • Protective complement proteins and age-related macular degenration
    Publication number: 20080280825
    Abstract: Methods for identifying a subject at risk for developing AMD are disclosed. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material. Therapeutic compositions and methods are also provided for delaying the progression or onset of the development of AMD in a subject, including treating a subject having signs and/or symptoms of AMD or who has been diagnosed with AMD.
    Type: Application
    Filed: August 20, 2007
    Publication date: November 13, 2008
    Applicants: University of Iowa Research Foundation, The Trustees of Columbia University in The City of New York, National Institutes of Health Office of Technology Transfer
    Inventors: Gregory S. Hageman, Rando Allikmets, Michael C. Dean, Albert M. Gold
  • Protective complement proteins and age-related macular degeneration
    Publication number: 20080146501
    Abstract: Methods for identifying a subject at risk for developing AMD are disclosed. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material. Therapeutic compositions and methods are also provided for delaying the progression or onset of the development of AMD in a subject, including treating a subject having signs and/or symptoms of AMD or who has been diagnosed with AMD.
    Type: Application
    Filed: February 13, 2007
    Publication date: June 19, 2008
    Applicants: University of Iowa Research Foundation, The Trustees of Columbia University in The City of New York, National Institutes of Health Office of Technology Transfer
    Inventors: Gregory S. Hageman, Rando Allikmets, Michael C. Dean, Albert M. Gold
  • Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter
    Patent number: 7192579
    Abstract: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
    Type: Grant
    Filed: January 3, 2003
    Date of Patent: March 20, 2007
    Assignees: Baylor College of Medicine, Johns Hopkins University, University of Utah Research Foundation, United States of America, Represented by the Secretary, Department of Health and Human Services, c/o National Institute of Health
    Inventors: Rando Allikmets, Kent L. Anderson, Michael Dean, Mark Leppert, Richard A. Lewis, Yixin Li, James R. Lupski, Jeremy Nathans, Amir Rattner, Noah F. Shroyer, Nanda Singh, Philip Smallwood, Hui Sun
  • Methods of screening and diagnostics using ATP-binding cassette transporter
    Patent number: 7189511
    Abstract: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
    Type: Grant
    Filed: January 3, 2003
    Date of Patent: March 13, 2007
    Assignees: Baylor College of Medicine, The United States of America as represented by the Department of Health and Human Services, University of Utah Research Foundation, John Hopkins University
    Inventors: Rando Allikmets, Kent L. Anderson, Michael Dean, Mark Leppert, Richard A. Lewis, Yixin Li, James R. Lupski, Jeremy Nathans, Amir Rattner, Noah F. Shroyer, Nanda Singh, Philip Smallwood, Hui Sun
  • ATP-binding cassette protein responsible for cytotoxin resistance
    Publication number: 20070048810
    Abstract: This invention provides for a novel ATP-binding cassette protein which is responsible for cytotoxin resistance. The invention also provides for methods of expressing the protein and assays for identification of inhibitors of the protein.
    Type: Application
    Filed: October 26, 2006
    Publication date: March 1, 2007
    Applicant: The Gov. of U.S.A. as Represented by the Secretary of the Department of Health and Human Services
    Inventors: Michael Dean, Rando Allikmets, Susan Bates, Antonio Fojo
  • Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter
    Patent number: 7141420
    Abstract: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: November 28, 2006
    Assignees: University of Utah Research Foundation, Baylor College of Medicine, John Hopkins University, The United States of America as represented by the Department of Health and Human Services
    Inventors: Rando Allikmets, Kent L. Anderson, Michael Dean, Mark Leppert, Richard A. Lewis, Yixin Li, James R. Lupski, Jeremy Nathans, Amir Rattner, Noah F. Shroyer, Nanda Singh, Philip Smallwood, Hui Sun
  • Nucleic acids of the human ABCC12 gene, vectors containing such nucleic acids and uses thereof
    Publication number: 20060063166
    Abstract: The present invention relates to a novel human ABCC12 gene as well as the cDNAs encoding the novel short and long of ABCC12 proteins isoforms. The invention also relates to vectors and recombinant host cells comprising such nucleic acids, nucleotide probes and primers, and means for the detection of polymorphisms and mutations in the ABCC12 gene or in the corresponding proteins isoforms produced by the allelic form of the ABCC12 gene.
    Type: Application
    Filed: December 16, 2004
    Publication date: March 23, 2006
    Applicant: Aventis Pharma S. A.
    Inventors: Marie Rosier, Catherine Prades, Isabelle Arnould, Michael Dean, Rando Allikmets, Patrice Denefle
  • Nucleic acids of the human ABCC11 gene, vectors containing such nucleic acids and uses thereof
    Publication number: 20050158784
    Abstract: The present invention relates to nucleic acids corresponding to various exons of the ABCC11 gene as well as the cDNA encoding the novel full length of ABCC11 protein. The invention also relates to means for the detection of polymorphisms in general, and of mutations in particular, in the ABCC11 gene or in the corresponding protein produced by the allelic form of the ABCC11 gene.
    Type: Application
    Filed: January 12, 2005
    Publication date: July 21, 2005
    Applicant: Aventis Pharma S.A.
    Inventors: Marie Rosier, Catherine Prades, Isabelle Arnould, Michael Dean, Rando Allikmets, Patrice Denefle
  • Nucleic acids of the human ABCC11 gene, vectors containing such nucleic acids and uses thereof
    Patent number: 6893841
    Abstract: The present invention relates to nucleic acids corresponding to various exons of the ABCC11 gene as well as the cDNA encoding the novel full length of ABCC11 protein. The invention also relates to means for the detection of polymorphisms in general, and of mutations in particular, in the ABCC11 gene or in the corresponding protein produced by the allelic form of the ABCC11 gene.
    Type: Grant
    Filed: March 5, 2002
    Date of Patent: May 17, 2005
    Assignee: Aventis Pharma S.A.
    Inventors: Marie Rosier, Catherine Prades, Isabelle Arnould, Michael Dean, Rando Allikmets, Patrice Denefle
  • ATP-binding transporter (ABC7) and methods for detection of anemia and ataxia
    Patent number: 6867017
    Abstract: Disclosed is a novel ATP-binding cassette gene (ABC7), polypeptide and methods of detecting mutations therein. Further, the disclosure provides methods of detecting ABC7 associated disease and treatments thereof. In particular, the disclosure provides methods of detecting X-linked Sideroblastic Anemia and Ataxia associated with a mutation in the ABC7 polypeptide.
    Type: Grant
    Filed: October 21, 1999
    Date of Patent: March 15, 2005
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Michael Dean, Rando Allikmets, Amy Ann Hutchinson
  • Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter
    Patent number: 6713300
    Abstract: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: March 30, 2004
    Assignees: University of Utah Research Foundation, Baylor College of Medicine, Johns Hopkins University, The United States of America as represented by the Department of Health and Human Services
    Inventors: Rando Allikmets, Kent L. Anderson, Michael Dean, Mark Leppert, Richard A. Lewis, Yixin Li, James R. Lupski, Jeremy Nathans, Amir Rattner, Noah F. Shroyer, Nanda Singh, Philip Smallwood, Hui Sun
  • Methods of screening and diagnostics using ATP-binding cassette transporter
    Publication number: 20030170852
    Abstract: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
    Type: Application
    Filed: January 3, 2003
    Publication date: September 11, 2003
    Inventors: Rando Allikmets, Kent L. Anderson, Michael Dean, Mark Leppert, Richard A. Lewis, Yixin Li, James R. Lupski, Jeremy Nathans, Amir Rattner, Noah F. Shroyer, Nanda Singh, Philip Smallwood, Hui Sun
  • Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter
    Publication number: 20030170853
    Abstract: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
    Type: Application
    Filed: January 3, 2003
    Publication date: September 11, 2003
    Inventors: Rando Allikmets, Kent L. Anderson, Michael Dean, Mark Leppert, Richard A. Lewis, Yixin Li, James R. Lupski, Jeremy Nathans, Amir Rattner, Noah F. Shroyer, Nanda Singh, Philip Smallwood, Hui Sun
  • Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter
    Publication number: 20030162276
    Abstract: The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
    Type: Application
    Filed: January 10, 2003
    Publication date: August 28, 2003
    Inventors: Rando Allikmets, Kent L. Anderson, Michael Dean, Mark Leppert, Richard A. Lewis, Yixin Li, James R. Lupski, Jeremy Nathans, Amir Rattner, Noah F. Shroyer, Nanda Singh, Philip Smallwood, Hui Sun
  • Nucleic acids of the human ABCC12 gene, vectors containing such nucleic acids, and uses thereof
    Publication number: 20030077605
    Abstract: The present invention relates to a novel human ABCC12 gene as well as the cDNAs encoding the novel short and long of ABCC12 proteins isoforms. The invention also relates to vectors and recombinant host cells comprising such nucleic acids, nucleotide probes and primers, and means for the detection of polymorphisms and mutations in the ABCC12 gene or in the corresponding proteins isoforms produced by the allelic form of the ABCC12 gene.
    Type: Application
    Filed: March 5, 2002
    Publication date: April 24, 2003
    Inventors: Marie Rosier, Catherine Prades, Isabelle Arnould, Michael Dean, Rando Allikmets, Patrice Denefle
  • Nucleic acids of the human ABCC11 gene, vectors containing such nucleic acids and uses thereof
    Publication number: 20030059793
    Abstract: The present invention relates to nucleic acids corresponding to various exons of the ABCC11 gene as well as the cDNA encoding the novel full length of ABCC11 protein. The invention also relates to means for the detection of polymorphisms in general, and of mutations in particular, in the ABCC11 gene or in the corresponding protein produced by the allelic form of the ABCC11 gene.
    Type: Application
    Filed: March 5, 2002
    Publication date: March 27, 2003
    Inventors: Marie Rosier, Catherine Prades, Isabelle Arnould, Michael Dean, Rando Allikmets, Patrice Denefle
  • Nucleic acids of the human ABCA5, ABCA6, ABCA9, AND ABCA10 Genes, vectors containing such nucleic acids, and uses thereof
    Publication number: 20030044895
    Abstract: The present invention relates to nucleic acids corresponding to various exons of ABCA5, ABCA6, ABCA9, and ABCA10 genes as well as cDNAs encoding the novel full length of ABCA5, ABCA6, ABCA9, and ABCA10 proteins. The invention also relates to means for the detection of polymorphisms in general, and of mutations in particular, in the ABCA5, ABCA6, ABCA9, and ABCA10 genes or in the corresponding protein produced by the allelic form of the ABCA5, ABCA6, ABCA9, and ABCA10 genes.
    Type: Application
    Filed: December 7, 2001
    Publication date: March 6, 2003
    Inventors: Patrice Denefle, Marie-Francoise Rosier-Montus, Catherine Prades, Isabelle Arnould-Reguigne, Nicolas Duverger, Rando Allikmets, Michael Dean