Patents by Inventor Randolph B. Deprince
Randolph B. Deprince has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130189219Abstract: Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.Type: ApplicationFiled: March 19, 2013Publication date: July 25, 2013Applicant: AMGEN INC.Inventors: Olaf B. Kinstler, Nancy Elise Gabriel, Christine E. Farrar, Randolph B. DePrince
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Publication number: 20120296072Abstract: Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.Type: ApplicationFiled: August 2, 2012Publication date: November 22, 2012Applicant: AMGEN INC.Inventors: Olaf B. Kinstler, Nancy Elise Gabriel, Christine E. Farrar, Randolph B. DePrince
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Patent number: 8258262Abstract: Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.Type: GrantFiled: December 16, 2009Date of Patent: September 4, 2012Assignee: Amgen Inc.Inventors: Olaf B. Kinstler, Nancy Elise Gabriel, Christine E. Farrar, Randolph B. DePrince
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Publication number: 20100310510Abstract: Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.Type: ApplicationFiled: December 16, 2009Publication date: December 9, 2010Applicant: AMGEN INC.Inventors: Olaf B. Kinstler, Nancy E. Gabriel, Christine E. Farrar, Randolph B. DePrince
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Patent number: 7662933Abstract: Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.Type: GrantFiled: April 26, 2006Date of Patent: February 16, 2010Assignee: Amgen Inc.Inventors: Olaf B. Kinstler, Nancy Elise Gabriel, Christine E. Farrar, Randolph B. DePrince
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Publication number: 20040181035Abstract: Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.Type: ApplicationFiled: March 26, 2001Publication date: September 16, 2004Applicant: Amgen, Inc.Inventors: Olaf B. Kinstler, Nancy E. Gabriel, Christine E. Farrar, Randolph B. DePrince
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Patent number: 6506362Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.Type: GrantFiled: April 10, 2001Date of Patent: January 14, 2003Assignee: Glaxo Group LimitedInventors: William J. Dower, Ronald W. Barrett, Steven E. Cwirla, Christian M. Gates, Peter J. Schatz, Palaniappan Balasubramanian, Christopher R. Wagstrom, Richard Wayne Hendren, Randolph B. Deprince, Surekha Podduturi, Qun Yin
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Patent number: 6251864Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.Type: GrantFiled: March 1, 2000Date of Patent: June 26, 2001Assignee: Glaxo Group LimitedInventors: William J. Dower, Ronald W. Barrett, Steven E. Cwirla, Christian M. Gates, Peter J. Schatz, Palaniappan Balasubramanian, Christopher R. Wagstrom, Richard Wayne Hendren, Randolph B. Deprince, Surekha Podduturi, Qun Yin
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Patent number: 6121238Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.Type: GrantFiled: February 3, 1999Date of Patent: September 19, 2000Assignee: Glaxo Wellcome Inc.Inventors: William J. Dower, Ronald W. Barrett, Steven E. Cwirla, Christian M. Gates, Peter J. Schatz, Palaniappan Balasubramanian, Christopher R. Wagstrom, Richard Wayne Hendren, Randolph B. Deprince, Surekha Podduturi, Qun Yin
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Patent number: 5985265Abstract: Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.Type: GrantFiled: June 20, 1997Date of Patent: November 16, 1999Assignee: Amgen Inc.Inventors: Olaf B. Kinstler, Nancy E. Gabriel, Christine E. Farrar, Randolph B. DePrince
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Patent number: 5824784Abstract: Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.Type: GrantFiled: October 12, 1994Date of Patent: October 20, 1998Assignee: Amgen Inc.Inventors: Olaf B. Kinstler, Nancy E. Gabriel, Christine E. Farrar, Randolph B. DePrince
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Patent number: 5705693Abstract: The present invention is directed to new cationic lipids and intermediates in their synthesis that are useful for transfecting nucleic acids or peptides into prokaryotic or eukaryotic cells. The lipids comprise one or two substituted arginine, lysine or ornithine residues, or derivatives thereof, linked to a lipophilic moiety. The lipids form a complex when mixed with polyanions such as nucleic acids or peptides. The complexes permit efficient transfer of polyanions into cells, usually without significant toxicity to the cells.Type: GrantFiled: July 7, 1995Date of Patent: January 6, 1998Assignee: Gilead Sciences, Inc.Inventors: Randolph B. DePrince, Kevin L. Facchine, George S. Lewis, Jason G. Lewis, Kuei-Ying Lin, Mark D. Matteucci, Robert A. Mook, Jr., Richard W. Wagner
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Patent number: 5008112Abstract: A device for the continuous administration of a diffusible agent having a relatively rapid rate of diffusion and a diffusible agent having a relatively show rate of diffusion comprises:a wall, formed at least in part by a porous membrane, which surrounds and defines a reservoir, the reservoir comprising:(a) a compartment which comprises the agent having the relatively slow rate of diffusion, wherein said compartment is in direct contact with the porous membrane part of the wall and(b) at least one compartment which comprises the agent having the relatively rapid rate of diffusion, wherein said compartment is not in direct contact with the porous membrane part of the wall and is separated from the compartment comprising the agent having the relatively slow rate of diffusion by a porous partition, such that when said device is exposed to said fluid medium, said agents will diffuse through the porous membrane part of said wall at a substantially steady rate for a prolonged period of time.Type: GrantFiled: December 16, 1985Date of Patent: April 16, 1991Assignee: International Minerals & Chem. CorporationInventors: Randolph B. DePrince, Ravi Viswanathan
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Patent number: 4917685Abstract: The present invention relates to a delivery device designed to be implanted in an animal and for the administration of a stabilized growth promoting formulation. This device has a wall formed at least in part by a porous membrane which surrounds and defines a reservoir. The reservoir contains a growth promoting hormone and a stabilizer. Examples of such stabilizers include certain polyols, amino acids, polymers of amino acids having a charged side group at physiological pH, and choline salts.Type: GrantFiled: May 16, 1986Date of Patent: April 17, 1990Assignee: International Minerals & Chem. Corp.Inventors: Ravi Viswanathan, Randolph B. DePrince
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Patent number: 4898733Abstract: A device for the continuous administration of a beneficial agent to a living being at a substantially steady rate which comprises:(a) a body fluid-contacting layer which comprises a dispersion of an agent which is substantially soluble in the body fluid and a solid matrix material, said matrix material comprising a polymer which is substantially insoluble in said body fluid, and(b) a non-body fluid-contacting layer which comprises said beneficial agent,wherein said body fluid-contacting layer is compression molded to said non-body fluid contacting layer.Type: GrantFiled: November 4, 1985Date of Patent: February 6, 1990Assignee: International Minerals & Chemical Corp.Inventors: Randolph B. DePrince, Ravi Viswanathan
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Patent number: 4765980Abstract: Porcine serum albumin stabilizes porcine growth hormone, and provided for sustained release of porcine growth hormone in implant devices for swine.Type: GrantFiled: April 28, 1986Date of Patent: August 23, 1988Assignee: International Minerals & Chemical Corp.Inventors: Randolph B. DePrince, Ravi Viswanathan
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Patent number: 4663147Abstract: A device for the release of a diffusible solid in a fluid medium which comprises a disc which comprises a substantially uniform mixture of said diffusible solid and a polymer which is insoluble in and impermeable to said fluid medium and impermeable to said diffusible solid. The surfaces of said disc are coated with a polymer which is insoluble in and impermeable to said fluid medium and impermeable to said diffusible solid, with the exception of one or more apertures which extend through the disc and expose a portion of the mixture of diffusible solid and polymer to the fluid medium when the device is immersed therein. The aperture or apertures are placed in said disc such that as said fluid medium enters the disc through said aperture or apertures, the ratio of surfce area of diffusible solid exposed to the fluid medium to the length of the path through which the exposed solid must diffuse to exit the disc remains substantially constant.Type: GrantFiled: September 3, 1985Date of Patent: May 5, 1987Assignee: International Minerals & Chemical Corp.Inventor: Randolph B. DePrince