Patents by Inventor Randolph Corteling

Randolph Corteling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190388475
    Abstract: This invention relates to stem cell microparticles, their use and production, in particular neural stem cell microparticles and their use in therapy. The stem cell microparticle is typically an exosome or microvesicle and may be derived from a neural stem cell line. The neural stem cell line may be a conditionally-immortalised stem cell line such as CTXOE03 (deposited at the ECACC with Accession No. 04091601).
    Type: Application
    Filed: August 28, 2019
    Publication date: December 26, 2019
    Inventors: John Sinden, Lara Stevanato, Randolph Corteling
  • Patent number: 10406182
    Abstract: This invention relates to stem cell microparticles and miRNA isolated from these microparticles, their use and production thereof, in particular neural stem cell microparticles and their use in therapy of cancer, typically a nestin-positive cancer. The cancer may be glioma, melanoma, breast cancer, pancreatic cancer or prostate cancer. The stem cell microparticle is typically an exosome or microvesicle and may be derived from a neural stem cell line. The neural stem cell line may be a conditionally-immortalized stem cell line such as CTX0E03 (deposited at the ECACC with Accession No. 04091601).
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: September 10, 2019
    Assignee: Reneuron Limited
    Inventors: Caroline Hicks, John Sinden, Lara Stevanato, Randolph Corteling
  • Patent number: 9629879
    Abstract: The present invention provides an isolated cell obtainable from the CTX0E03 neural stem cell line for use in the treatment of a disorder associated with elevated levels of pro-inflammatory cytokines, wherein the disorder is selected from unipolar and bipolar depression, schizophrenia, obsessive compulsive disorder, autism and autistic syndrome disorders.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: April 25, 2017
    Assignee: RENEURON LIMITED
    Inventors: Randolph Corteling, Caroline Hicks, John Sinden, Jack Price
  • Publication number: 20160235788
    Abstract: This invention relates to stem cell microparticles and miRNA isolated from these microparticles, their use and production thereof, in particular neural stem cell microparticles and their use in therapy of cancer, typically a nestin-positive cancer. The cancer may be glioma, melanoma, breast cancer, pancreatic cancer or prostate cancer. The stem cell microparticle is typically an exosome or microvesicle and may be derived from a neural stem cell line. The neural stem cell line may be a conditionally-immortalised stem cell line such as CTX0E03 (deposited at the ECACC with Accession No. 04091601).
    Type: Application
    Filed: October 9, 2014
    Publication date: August 18, 2016
    Inventors: Caroline Hicks, John Sinden, Lara Stevanato, Randolph Corteling
  • Publication number: 20160193252
    Abstract: This invention relates to stem cell microparticles and miRNA isolated from these microparticles, their use and production thereof, in particular neural stem cell microparticles and their use in therapy of a disease or condition involving unwanted or undesirable cell migration. The stem cell microparticle is typically an exosome or microvesicle and may be derived from a neural stem cell line. The neural stem cell line may be a conditionally-immortalised stem cell line such as CTX0E03 (deposited at the ECACC with Accession No. 04091601).
    Type: Application
    Filed: August 14, 2014
    Publication date: July 7, 2016
    Inventors: Caroline Hicks, John Sinden, Lara Stevanato, Randolph Corteling
  • Publication number: 20160002597
    Abstract: The invention is based on the finding that microparticles can be produced by conditionally-immortalised cells. The conditionally-immortalised cells may be stem cells. The Examples show the successful harvest of microparticles from conditionally immortalised neural stem cells and CD34+ cells. Conditional immortalisation provides a constant supply of clonal cells that produce microparticles such as exosomes. The conditionally immortalised cells are useful as “producer cells” for microparticles such as exosomes, which are typically harvested or isolated from the conditionally-immortalised cells.
    Type: Application
    Filed: February 12, 2014
    Publication date: January 7, 2016
    Inventors: John Sinden, Lara Stevanato, Randolph Corteling
  • Publication number: 20150366897
    Abstract: This invention relates to stem cell microparticles and miRNA isolated from these microparticles, their use and production, in particular neural stem cell microparticles and their use in therapy. The stem cell microparticle is typically an exosome or microvesicle and may be derived from a neural stem cell line. The neural stem cell line may be a conditionally-immortalised stem cell line such as CTX0E03 (deposited at the ECACC with Accession No. 04091601). Identified miRNAs include hsa-miR-1246, hsa-miR-4492, hsa-miR-4488 and hsa-miR-4532.
    Type: Application
    Filed: February 12, 2014
    Publication date: December 24, 2015
    Inventors: Lara Stevanato, Randolph Corteling, John Sinden
  • Publication number: 20150164955
    Abstract: This invention relates to stem cell microparticles, their use and production, in particular neural stem cell microparticles and their use in therapy. The stem cell microparticle is typically an exosome or microvesicle and may be derived from a neural stem cell line. The neural stem cell line may be a conditionally-immortalised stem cell line such as CTX0E03 (deposited at the ECACC with Accession No. 04091601).
    Type: Application
    Filed: July 18, 2013
    Publication date: June 18, 2015
    Inventors: John Sinden, Lara Stevanato, Randolph Corteling
  • Publication number: 20150079046
    Abstract: This invention relates to stem cell microparticles, their use and production, in particular neural stem cell microparticles and their use in therapy. The stem cell microparticle is typically an exosome or microvesicle and may be derived from a neural stem cell line. The neural stem cell line may be a conditionally-immortalised stem cell line such as CTX0E03 (deposited at the ECACC with Accession No. 04091601).
    Type: Application
    Filed: April 3, 2013
    Publication date: March 19, 2015
    Inventors: John Sinden, Lara Stevanato, Randolph Corteling
  • Publication number: 20130171177
    Abstract: The present invention provides an isolated cell obtainable from the CTX0E03 neural stem cell line for use in the treatment of a disorder associated with elevated levels of pro-inflammatory cytokines, wherein the disorder is selected from unipolar and bipolar depression, schizophrenia, obsessive compulsive disorder, autism and autistic syndrome disorders.
    Type: Application
    Filed: July 11, 2011
    Publication date: July 4, 2013
    Applicant: RENEURON LIMITED
    Inventors: Randolph Corteling, Caroline Hicks, John Sinden, Jack Price