Patents by Inventor Randolph L. Greasham

Randolph L. Greasham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for improving culture medium for recombinant yeast
    Patent number: 6232111
    Abstract: Yields in yeast recombinant expression systems are improved by identifying bad lots and supplementing them with the appropriate combination of adenine, trehalose and/or lactate.
    Type: Grant
    Filed: March 31, 1997
    Date of Patent: May 15, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Jinyou Zhang, Randolph L. Greasham
  • Conversion of indene to (1S)-amino-(2R)-indanol free of any stereoisomer, by combination of dioxygenase bioconversion and chemical steps
    Patent number: 5858737
    Abstract: A process is disclosed that bioconverts indene to (1S)-amino-(2R)-indanol substantially free of any of its stereoisomers, by the action of a strain of P. putida or Rhodococcus sp., followed by various chemical step(s), e.g., chiral specific crystallization, treatment with strong acid in the presence of acetonitrile.
    Type: Grant
    Filed: August 14, 1996
    Date of Patent: January 12, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Barry C. Buckland, Neal C. Connors, Michel M. Chartrain, Francis P. Gailliot, Randolph L. Greasham, Barbara Jackey, Brian Heimbuch, Chanyong Lee, Roger C. Olewinski, Jr., F. Edward Roberts, Paul J. Reider, Thomas R. Verhoeven, Chris H. Senanayake
  • Biological flocculation of mineral slimes
    Patent number: 4456532
    Abstract: A process for the consolidation of mineral slimes resulting from the beneficiation of ores comprising the steps of mixing the slimes with a microorganism species or a mixture thereof or ruptured or dried cells thereof, or a fermentation beer on which the organism was grown wherein the organism is selected from the group of cyanobacteria and allowing the mixture to separate into a clear upper layer and a consolidated slimes lower layer.
    Type: Grant
    Filed: May 9, 1983
    Date of Patent: June 26, 1984
    Assignee: International Minerals & Chemical Corp.
    Inventors: John F. Leslie, Randolph L. Greasham, Matthew H. Hulbert