Abstract: Compositions and methods are described for the delivery of a fully human post-translationally modified therapeutic monoclonal antibody that binds to CGRP or CGRP receptor to a human subject for the treatment or prevention of migraines and cluster headaches. The antibodies may be delivered by gene therapy vectors, particularly rAAV vectors. Also provided are dual transgene constructs for the delivery of anti-CGRP and anti-CGRP receptor antibodies or antigen binding fragments thereof.

Abstract: A control system manipulates one or more of the shape, timing, and magnitude of a pressure pulse (“plasma pulse trajectory”) generated by a plasma compression system to implode a liquid liner surrounding a cavity containing plasma, thereby compressing the plasma. The liquid liner and cavity are created by rotating a liquid medium in a vessel. Compression drivers extend perpendicularly around the liquid medium's rotational axis. Multiple layers of compression drivers are stacked in an axial direction parallel to the rotational axis to form multiple pressure zones extending along the rotational axis. The control system separately controls each pressure zone, or groups of pressure zones, to generate individual pressure pulses each having a different pressure pulse trajectory in each pressure zone. The multiple individual pressure pulses collectively form a combined pressure pulse having a pressure pulse trajectory that varies along the rotational axis.

Abstract: A plasma compression system comprises a plasma containment vessel, an annular rotating core inside the vessel, and a plurality of compression drivers fixedly mounted to an outer surface of the vessel wall. The annular rotating core contains a liquid medium and is rotatable to circulate the liquid medium and form a liquid liner with a cavity. The rotating core comprises an outer surface spaced from an inner surface of the vessel wall to define an annular gap, and a plurality of implosion drivers each comprising a pusher bore with a pusher piston slideable therein. Each pusher bore extends through the rotating core. The plurality of compression drivers compresses a compression fluid in the annular gap and creates a pressure pulse, such that when the rotating core rotates and the liquid medium fills the pusher bores, the pusher pistons are operable to push the liquid medium inwards to collapse the liquid liner and compress a plasma in the cavity.

Abstract: Methods, systems and computer readable media for color management are described. In some implementations, the method can include accessing one or more buildup curves associated with a combination of a substrate, one or more colorants and a colorant dispenser. The method can also include accessing a design file specifying a design and including one or more layer files each specifying a layer color. The method can further include generating, for each layer color, a corresponding colorization recipe based on the one or more buildup curves. The method can also include creating a production job instruction/metadata file having a link to the design instruction/metadata file and including parameters associated with the colorant dispensing job to be carried out using the design instruction/metadata file.

Abstract: A self-flushing connector includes a housing having a cavity, a first inlet port, a second inlet port, and an outlet port. A collapsible valve is disposed within the cavity. A first flow path extends from the first inlet port to the outlet port. The first inlet port and the second inlet port are fluidly connected through a gap defined between the body of the collapsible valve and an inner wall of the housing defining the cavity. A second flow path extends from the second inlet port to the first flow path. When the collapsible valve is in a closed state, the collapsible valve fluidly disconnects the second flow path from the first flow path while allowing fluid to flow through the first flow path. When the collapsible valve is in an open state, the second flow path is fluidly connected to the first flow path.

Abstract: A self-flushing connector includes a housing having a cavity, a first inlet port, a second inlet port, and an outlet port. A collapsible valve is disposed within the cavity. A first flow path extends from the first inlet port to the outlet port. The first inlet port and the second inlet port are fluidly connected through a gap defined between the body of the collapsible valve and an inner wall of the housing defining the cavity. A second flow path extends from the second inlet port to the first flow path. When the collapsible valve is in a closed state, the collapsible valve fluidly disconnects the second flow path from the first flow path while allowing fluid to flow through the first flow path. When the collapsible valve is in an open state, the second flow path is fluidly connected to the first flow path.

Abstract: A self-flushing connector includes a housing having a cavity, a first inlet port, a second inlet port, and an outlet port. A collapsible valve is disposed within the cavity. A first flow path extends from the first inlet port to the outlet port. The first inlet port and the second inlet port are fluidly connected through a gap defined between the body of the collapsible valve and an inner wall of the housing defining the cavity. A second flow path extends from the second inlet port to the first flow path. When the collapsible valve is in a closed state, the collapsible valve fluidly disconnects the second flow path from the first flow path while allowing fluid to flow through the first flow path. When the collapsible valve is in an open state, the second flow path is fluidly connected to the first flow path.

Abstract: Methods, systems and computer readable media for color management are described. In some implementations, the method can include accessing one or more buildup curves associated with a combination of a substrate, one or more colorants and a colorant dispenser. The method can also include accessing a design file specifying a design and including one or more layer files each specifying a layer color. The method can further include generating, for each layer color, a corresponding colorization recipe based on the one or more buildup curves. The method can also include creating a production job instruction/metadata file having a link to the design instruction/metadata file and including parameters associated with the colorant dispensing job to be carried out using the design instruction/metadata file.

Abstract: A self-flushing connector includes a housing having a cavity, a first inlet port, a second inlet port, and an outlet port. A collapsible valve is disposed within the cavity. A first flow path extends from the first inlet port to the outlet port. The first inlet port and the second inlet port are fluidly connected through a gap defined between the body of the collapsible valve and an inner wall of the housing defining the cavity. A second flow path extends from the second inlet port to the first flow path. When the collapsible valve is in a closed state, the collapsible valve fluidly disconnects the second flow path from the first flow path while allowing fluid to flow through the first flow path. When the collapsible valve is in an open state, the second flow path is fluidly connected to the first flow path.

Abstract: Methods, systems and computer readable media for color management are described. In some implementations, the method can include accessing one or more buildup curves associated with a combination of a substrate, one or more colorants and a colorant dispenser. The method can also include accessing a design file specifying a design and including one or more layer files each specifying a layer color. The method can further include generating, for each layer color, a corresponding colorization recipe based on the one or more buildup curves. The method can also include creating a production job instruction/metadata file having a link to the design instruction/metadata file and including parameters associated with the colorant dispensing job to be carried out using the design instruction/metadata file.

Abstract: Methods, systems and computer readable media for color management are described. In some implementations, the method can include accessing one or more buildup curves associated with a combination of a substrate, one or more colorants and a colorant dispenser. The method can also include accessing a design file specifying a design and including one or more layer files each specifying a layer color. The method can further include generating, for each layer color, a corresponding colorization recipe based on the one or more buildup curves. The method can also include creating a production job instruction/metadata file having a link to the design instruction/metadata file and including parameters associated with the colorant dispensing job to be carried out using the design instruction/metadata file.

Abstract: A system for scanning a body to create scan data comprises a processor, a range camera capable of capturing at least a first set of depth images of the body rotated to 0 degrees, and at least a second set of depth images of the body rotated to x degrees, wherein x is >0 degrees, and x <360 degrees. A set of computer instructions are executable on a processor capable of creating biometrics based on extracted body measurement from the body scan.

Abstract: A system for scanning a body to create scan data comprises a processor, a range camera capable of capturing at least a first set of depth images of the body rotated to 0 degrees, and at least a second set of depth images of the body rotated to x degrees, wherein x is >0 degrees, and x<360 degrees. a set of computer instructions are executable on a processor capable of synchronizing scan data and body measurements with a server.

Abstract: Methods, systems and computer readable media for color management are described. In some implementations, the method can include accessing one or more buildup curves associated with a combination of a substrate, one or more colorants and a colorant dispenser. The method can also include accessing a design file specifying a design and including one or more layer files each specifying a layer color. The method can further include generating, for each layer color, a corresponding colorization recipe based on the one or more buildup curves. The method can also include creating a production job instruction/metadata file having a link to the design instruction/metadata file and including parameters associated with the colorant dispensing job to be carried out using the design instruction/metadata file.

Abstract: A self-flushing connector includes a housing having a cavity, a first inlet port, a second inlet port, and an outlet port. A collapsible valve is disposed within the cavity. A first flow path extends from the first inlet port to the outlet port. The first inlet port and the second inlet port are fluidly connected through a gap defined between the body of the collapsible valve and an inner wall of the housing defining the cavity. A second flow path extends from the second inlet port to the first flow path. When the collapsible valve is in a closed state, the collapsible valve fluidly disconnects the second flow path from the first flow path while allowing fluid to flow through the first flow path. When the collapsible valve is in an open state, the second flow path is fluidly connected to the first flow path.

Abstract: A combustor component defining a dilution hole configuration for a combustor wall assembly of a gas turbine engine has first and second dilution holes that communicate radially with one-another and with respect to respective centerlines of each dilution hole. In operation, each dilution hole forms a respective jet stream along respective centerlines for flowing cooling air into a combustion chamber.

Abstract: Methods, systems and computer readable media for color management are described. In some implementations, the method can include accessing one or more buildup curves associated with a combination of a substrate, one or more colorants and a colorant dispenser. The method can also include accessing a design file specifying a design and including one or more layer files each specifying a layer color. The method can further include generating, for each layer color, a corresponding colorization recipe based on the one or more buildup curves. The method can also include creating a production job instruction/metadata file having a link to the design instruction/metadata file and including parameters associated with the colorant dispensing job to be carried out using the design instruction/metadata file.

Abstract: A combustor component defining a dilution hole configuration for a combustor wall assembly of a gas turbine engine has first and second dilution holes that communicate radially with one-another and with respect to respective centerlines of each dilution hole. In operation, each dilution hole forms a respective jet stream along respective centerlines for flowing cooling air into a combustion chamber.

Abstract: A system for scanning a body to create scan data comprises a processor, a range camera capable of capturing at least a first set of depth images of the body rotated to 0 degrees, and at least a second set of depth images of the body rotated to x degrees, wherein x is >0 degrees, and x<360 degrees. A set of computer instructions are executable on a processor capable of creating biometrics based on extracted body measurement from the body scan.