Patents by Inventor Randy Chandler

Randy Chandler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12201658
    Abstract: Provided herein are compositions and methods for the viral gene therapy (e.g., AAV-directed gene therapy) of cholesterol storage diseases or disorders, such as Niemann-Pick disease, Type C.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: January 21, 2025
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Charles P. Venditti, Randy Chandler, William J. Pavan
  • Publication number: 20230383278
    Abstract: The present disclosure provides adeno-associated viral vectors, recombinant adeno-associated virus (rAAV) and methods of using such vectors and viruses in gene therapy for treating methylmalonic acidemia in patients with methylmalonyl-coA mutase (MVMUT) deficiency. Also provided are pharmaceutical compositions comprising recombinant adeno-associated virus (rAAV) and a pharmaceutically acceptable carrier or excipient.
    Type: Application
    Filed: September 16, 2021
    Publication date: November 30, 2023
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Charles P. Venditti, Randy Chandler
  • Patent number: 11447797
    Abstract: The invention provides an adeno-associated viral (AAV) vector comprising a capsid comprising the amino acid sequence of SEQ ID NO: 4 or SEQ ID NO: 9, wherein the AAV vector further comprises a heterologous nucleic acid sequence, and wherein the heterologous nucleic acid sequence can encode the NGF-PTH fusion polypeptide or methylmalonyl CoA mutase enzyme. The invention also provides a polypeptide comprising nerve growth factor (NGF) signal peptide and parathyroid hormone (PTH), wherein the polypeptide can comprise, consist essentially of, or consist of the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2. The invention provides a nucleic acid encoding the polypeptide, a vector comprising the nucleic acid, and a composition comprising the polypeptide, nucleic acid, or vector, as well as treatment methods comprising the polypeptide, nucleic acid, vector, or composition.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: September 20, 2022
    Assignee: The United States of America,as represented by the Secretary, Department of Health and Human Service
    Inventors: John A. Chiorini, Giovanni Di Pasquale, Randy Chandler, Charles P. Venditti
  • Publication number: 20210113635
    Abstract: Provided herein are compositions and methods for the viral gene therapy (e.g.
    Type: Application
    Filed: September 25, 2020
    Publication date: April 22, 2021
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Charles P. Venditti, Randy Chandler, William J. Pavan
  • Publication number: 20180104289
    Abstract: Provided herein are compositions and methods for the viral gene therapy (e.g., AAV-directed gene therapy) of cholesterol storage diseases or disorders, such as Niemann-Pick disease, Type C.
    Type: Application
    Filed: April 7, 2016
    Publication date: April 19, 2018
    Applicants: Services
    Inventors: Charles P. Venditti, Randy Chandler, William J. Pavan
  • Publication number: 20130009054
    Abstract: The invention provides a device including a chamber wherein the chamber including a rigid enclosure; a rigid lid for the enclosure; a gasket between the lid and the enclosure to allow for an airtight seal between the enclosure and the gasket upon closure of a latch connecting the enclosure and the lid; a port for airtight attachment of a syringe, and a port for airtight insertion of a gas sensor. The device can further include a gas sensor and one or more syringes for attachment to the device by a three-way stopcocks. The device is appropriately sized for use with the subject of interest. The invention also provides methods for use of the device.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: Government ot the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: Charles P. Venditti, Randy Chandler
  • Patent number: 8293187
    Abstract: The invention provides a device including a chamber wherein the chamber including a rigid enclosure; a rigid lid for the enclosure; a gasket between the lid and the enclosure to allow for an airtight seal between the enclosure and the gasket upon closure of a latch connecting the enclosure and the lid; a port for airtight attachment of a syringe, and a port for airtight insertion of a gas sensor. The device can further include a gas sensor and one or more syringes for attachment to the device by a three-way stopcocks. The device is appropriately sized for use with the subject of interest. The invention also provides methods for use of the device.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: October 23, 2012
    Assignee: The United States of America, as Represented by the Secretary, Department of Health and Human Services
    Inventors: Charles P. Venditti, Randy Chandler
  • Publication number: 20100252732
    Abstract: The invention provides a device including a chamber wherein the chamber including a rigid enclosure; a rigid lid for the enclosure; a gasket between the lid and the enclosure to allow for an airtight seal between the enclosure and the gasket upon closure of a latch connecting the enclosure and the lid; a port for airtight attachment of a syringe, and a port for airtight insertion of a gas sensor. The device can further include a gas sensor and one or more syringes for attachment to the device by a three-way stopcocks. The device is appropriately sized for use with the subject of interest. The invention also provides methods for use of the device.
    Type: Application
    Filed: April 6, 2009
    Publication date: October 7, 2010
    Applicant: Government of the US, as represented by the Secretary, Department of Health and Human Services
    Inventors: Charles P. Venditti, Randy Chandler