Patents by Inventor Randy K. Bledsoe

Randy K. Bledsoe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystallized glucocorticoid receptor ligand binding domain polypeptide and screening methods employing same
    Patent number: 7238778
    Abstract: A method of modifying a test nuclear receptor (NR) polypeptide is disclosed. The method provides a test NR polypeptide sequence having a characteristic that is targeted for modification; aligning the test NR polypeptide sequence with at least one reference NR polypeptide sequence for which an X-ray structure is available; building a three-dimensional model for the test NR polypeptide using the three-dimensional coordinates of the X-ray structure(s) of at least one reference polypeptide and its sequence alignment with the test NR polypeptide sequence; examining the three-dimensional model of the test NR polypeptide sequence for characteristic differences with the reference polypeptide; and mutating at least one amino acid residue in the test NR polypeptide sequence at a characteristic difference, whereby the test NR polypeptide is modified.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: July 3, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Christopher J. Apolito, Randy K. Bledsoe, Millard H. Lambert, III, David D. McKee, Valerie Gail Montana, Kenneth H. Pearce, Thomas B. Stanley, Huaqiang Eric Xu, Christopher J Delves
  • Crystallized LXR polypeptide in complex with a ligand and screening methods employing same
    Publication number: 20040018560
    Abstract: Solved three-dimensional crystal structures of a human LXR ligand binding domain polypeptide in complex with one or more of a ligand and a coactivator polypeptide is disclosed. Contact points between the LXR and the ligands are also disclosed. Additionally, methods of designing modulators of the biological activity of LXR, and other LXR ligand binding domain polypeptides, are also disclosed.
    Type: Application
    Filed: April 17, 2003
    Publication date: January 29, 2004
    Inventors: Randy K. Bledsoe, Ann Miller, John T. Moore, Linda Moore, Shawn P. Williams, George B. Wisely