Abstract: A system and method for measuring a functional lateralization of a subject brain is provided. The method includes providing a set of functional magnetic resonance imaging (fMRI) data acquired during a resting state of a subject, and selecting a plurality of seed voxels associated with locations in hemispheres of a brain of the subject. The method also includes determining a degree of within-hemisphere connectivity for each seed voxel using the fMRI data, determining a degree of cross-hemisphere connectivity for each seed voxel using the fMRI data, and computing an autonomy index for each seed voxel using the degree of within-hemisphere connectivity and the degree of cross-hemisphere connectivity, wherein the autonomy index is indicative of a connectivity asymmetry between the hemispheres. The method further includes generating a report indicative of a specialization profile determined for a region of interest in the brain of the subject.

Abstract: A system and method for measuring a functional lateralization of a subject brain is provided. The method includes providing a set of functional magnetic resonance imaging (fMRI) data acquired during a resting state of a subject, and selecting a plurality of seed voxels associated with locations in hemispheres of a brain of the subject. The method also includes determining a degree of within-hemisphere connectivity for each seed voxel using the fMRI data, determining a degree of cross-hemisphere connectivity for each seed voxel using the fMRI data, and computing an autonomy index for each seed voxel using the degree of within-hemisphere connectivity and the degree of cross-hemisphere connectivity, wherein the autonomy index is indicative of a connectivity asymmetry between the hemispheres. The method further includes generating a report indicative of a specialization profile determined for a region of interest in the brain of the subject.

Abstract: Systems and methods for pre-operatively identifying functional regions of a patient's brain to assist in the preparation of a contemplated surgery. The systems and methods make use of correlations between regions of the patient's brain that exhibit spontaneous brain activity. The systems and methods may be used with any patient but solve a particular need for subjects that are unable to complete traditional task-based brain mapping studies.