Abstract: A method for seperating ions is disclosed. A first analyzer region is provided defined by a space between first and second spaced apart electrodes. A second analyser region is defined in operational communication with the first analyzer region and having two electrodes. Ions are provided to one of the first analyzer region and the second analyzer region and then coupled from there to the other analyzer region. A first asymmetric waveform and a first direct-current compensation voltage are applied to electrodes for providing an electric field within the first analyzer region. The first asymmetric waveform is typically selected for effecting a difference in net displacement between two different ions in the time of one cycle of the applied first asymmetric waveform and the first compensation voltage is selected to support selective transmission of a first subset of the ions within the first analyzer region.

Abstract: A method and an apparatus is disclosed for selectively transmitting ions with a FAIMS analyzer in which a flow of carrier gas of a mixed composition is provided. Ions that are transmitted at a same combination of applied potentials when a first carrier gas is provided are in certain cases transmitted at different combinations of applied potentials when a second other carrier gas having a different composition is provided.

Abstract: A method and an apparatus is disclosed for selectively transmitting ions in which the ions are subjected to a focusing effect such that the overall efficiency of ion transmission is increased. The method relies on a FAIMS analyzer having at least an electrode disposed approximately between two other electrode surfaces for producing an electric field that is symmetric on opposing sides of the at least an electrode. An ion exiting from between the electrodes experiences a balanced electric field, such that impact with one of the electrodes is prevented.

Abstract: A method and an apparatus for selectively transmitting ions produced by a laser-based ionization technique is disclosed. The method relies on a FAIMS analyzer having a surface disposed therein for receiving a sample on the surface. The surface is in optical communication with a light transmissive port through which the laser light is directed such that it impinges upon the sample and causes ioniztaion thereof.

Abstract: A method for selectively transmitting ions using a FAIMS device is disclosed. A first analyzer region is defined by a space between first and second spaced apart electrodes. A second analyser region is provided in operational communication with the first analyzer region. Ions are provided to the first analyzer region. The ions are coupled from the first analyser region to the second analyzer region. An asymmetric waveform is used to generate an electric field within the first analyser region and a compensation voltage is applied to prevent some ions from exiting the analyser region. Conditions are provided within the second analyzer region for effecting a second different separation of ions therein. Finally, the separated ions are trapped to accumulate ions within a trapping region thereof.