Patents by Inventor Randy Ranjee Ramharack

Randy Ranjee Ramharack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amide inhibitors of microsomal triglyceride transfer protein
    Patent number: 6780883
    Abstract: The present invention provides compounds having the Formula I The present invention also provides pharmaceutical compositions comprising a compound of Formula I and methods of treatment of atherosclerosis, obesity, restenosis, coronary heart disease, hyperlipoproteinemia, hypercholesterolemia, and hypertriglyceridemia.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: August 24, 2004
    Assignee: Warner-Lambert Company
    Inventors: Richard John Booth, Helen Tsenwhei Lee, Jason Keith Pontrello, Randy Ranjee Ramharack, Bruce David Roth
  • Statin-Lp(a) inhibitor combinations
    Publication number: 20040092574
    Abstract: The invention is a pharmaceutical composition comprising an Lp(a) inhibitor and a statin which inhibits HMG-CoA reductase, said composition being useful for treating vascular diseases.
    Type: Application
    Filed: August 25, 2003
    Publication date: May 13, 2004
    Inventors: Charles Larry Bisgaier, Roger Schofield Newton, Randy Ranjee Ramharack
  • Diacylglycerol acyltransferase (DGAT) assay
    Patent number: 6607893
    Abstract: The present invention provides a method for measuring diacylglycerol acetyltransferase (DGAT) activity which utilizes a novel solvent system to reduce and/or eliminate the activities of related compounds. The present invention also discloses a method for determining whether a compound is useful for modulating DGAT biological activity. The method is capable of being utilized for mass screening of compounds as modulators of the biological activity of DGAT.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: August 19, 2003
    Assignee: Warner-Lambert Company
    Inventors: Randy Ranjee Ramharack, Mark Allan Spahr
  • Amide inhibitors of microsomal triglyceride transfer protein
    Publication number: 20020156281
    Abstract: The present invention provides compounds having the Formula I 1
    Type: Application
    Filed: December 12, 2001
    Publication date: October 24, 2002
    Inventors: Richard John Booth, Helen Tsenwhei Lee, Jason Keith Pontrello, Randy Ranjee Ramharack, Bruce David Roth
  • Sulfonamide compounds and methods of treating atherosclerosis and restenosis
    Patent number: 6458815
    Abstract: The present invention provides compounds having the Formula I The present invention also provides methods of treating or preventing atherosclerosis, coronary heart disease, and restenosis using the compounds of Formula I, and pharmaceutical compositions comprising the compounds of Formula I.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: October 1, 2002
    Assignee: Warner-Lambert Company
    Inventors: Helen Tsenwhei Lee, Randy Ranjee Ramharack, Bruce David Roth, Karen Elaine Sexton
  • Diacylglycerol acyltransferase (DGAT) assay
    Publication number: 20020127627
    Abstract: The present invention provides a method for measuring diacylglycerol acetyltransferase (DGAT) activity which utilizes a novel solvent system to reduce and/or eliminate the activities of related compounds.
    Type: Application
    Filed: December 19, 2001
    Publication date: September 12, 2002
    Inventors: Randy Ranjee Ramharack, Mark Allan Spahr
  • Sulfonamide compounds and methods of treating atherosclerosis and restenosis
    Patent number: 6284795
    Abstract: The present invention provides compounds having the Formula I The present invention also provides methods of treating or preventing atherosclerosis, coronary heart disease, and restenosis using the compounds of Formula I, and pharmaceutical compositions comprising the compounds of Formula I.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: September 4, 2001
    Assignee: Warner-Lambert Company
    Inventors: Helen Tsenwhei Lee, Randy Ranjee Ramharack, Bruce David Roth, Karen Elaine Sexton
  • Sulfonamide compounds and methods of treating atherosclerosis and restenosis
    Publication number: 20010018523
    Abstract: The present invention provides compounds having the Formula I 1
    Type: Application
    Filed: April 13, 2001
    Publication date: August 30, 2001
    Inventors: Helen Tsenwhei Lee, Randy Ranjee Ramharack, Bruce David Roth, Karen Elaine Sexton
  • Method of lowering plasma levels of lipoprotein(a)
    Patent number: 5929091
    Abstract: The present invention comprises a method of lowering plasma levels of Lp(a) in animals by administering an effective Lp(a)-reducing amount of a microsomal triglyceride transfer protein inhibitor of the structural formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is alkyl, alkenyl alkynyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, cycloalkyl, or cycloalkylalkyl, each of which is independently optionally substituted through available carbon atoms with 1, 2, or 3 groups selected from halo, alkyl, alkenyl, alkoxy, aryloxy, aryl, arylalkyl, alkylmercapto, arylmercapto, cycloalkyl, cycloalkylalkyl, heteroaryl, and heteroarylalkyl. By lowering Lp(a) levels, the animals are protected against developing premature atherosclerosis and consequent cardiovascular and cerebrovascular diseases.
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: July 27, 1999
    Assignee: Warner-Lambert Company
    Inventors: Helen Tsenwhei Lee, Randy Ranjee Ramharack
  • Sulfhydryl containing peptides for treating vascular disease
    Patent number: 5786335
    Abstract: Sulfhydryl containing peptides having the formulaX--A.sub.1 --A.sub.2 --A.sub.3 --A.sub.4 --A.sub.5 --Yinhibit the formation of Lp(a) and thus are useful for treating vascular diseases such as coronary heart disease, myocardial infarction, ischemic stroke, cervical atherosclerosis, cerebral infarction, and restenosis.
    Type: Grant
    Filed: October 31, 1996
    Date of Patent: July 28, 1998
    Assignee: Warner-Lambert Company
    Inventors: Wayne Livingston Cody, Helen Tsenwhei Lee, Randy Ranjee Ramharack, Bruce David Roth, Tomi Sawyer, Drago Robert Sliskovic
  • Isothiazolones lower plasma levels of lipoprotein(a)
    Patent number: 5668162
    Abstract: Plasma levels of Lp(a) are lowered by administering an isothiazolone having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het.
    Type: Grant
    Filed: May 7, 1996
    Date of Patent: September 16, 1997
    Inventors: John Michael Domagala, Helen Tsenwhei Lee, Randy Ranjee Ramharack, Bruce David Roth, Tomi Sawyer, Drago Robert Sliskovic