Patents by Inventor Rangan Maitra

Rangan Maitra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic apelin receptor (APJ) agonists and uses thereof
    Patent number: 11926612
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) with heterocyclic cores and uses of such agonists.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: March 12, 2024
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, Kenneth S. Rehder
  • INDAZOLE DERIVATIVES AS CANNABINOID RECEPTOR PARTIAL AGONISTS
    Publication number: 20230339863
    Abstract: The present disclosure includes peripheral partial agonists of one or more CB receptors, including modulation of CB1, both with and without CB2 selectivity. The compounds of the present disclosure may be useful in the treatment of diseases and disorders mediated by a CB-signaling pathway, including but not limited to pain, gastrointestinal disorders, metabolic disorders, and liver disorders, such as alcoholic steatohepatitis or nonalcoholic steatohepatitis (NASH).
    Type: Application
    Filed: January 29, 2021
    Publication date: October 26, 2023
    Inventors: George AMATO, Rangan MAITRA, Scott P. RUNYON
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 11535630
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: December 27, 2022
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
  • METHODS AND USES FOR APELIN RECEPTOR AGONISTS
    Publication number: 20220280483
    Abstract: The present disclosure provides a method for treating idiopathic pulmonary fibrosis in a patient in need thereof comprising administering a therapeutically effective amount of an apelin receptor agonist.
    Type: Application
    Filed: August 28, 2020
    Publication date: September 8, 2022
    Inventors: Rangan MAITRA, Sanju NARAYANAN, Kenneth S. REHDER, Scott P. RUNYON
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 11401244
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: August 2, 2022
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 11267789
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: March 8, 2022
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 10954247
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: March 23, 2021
    Assignee: Research Triangle Institute
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
  • APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20210070767
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Application
    Filed: October 28, 2020
    Publication date: March 11, 2021
    Inventors: Scott P. RUNYON, Rangan MAITRA, Sanju NARAYANAN, James Barnwell THOMAS, Kenneth S. REHDER, Srinivas OLEPU
  • Diaryl purine derivatives with improved bioavailability
    Patent number: 10696677
    Abstract: This disclosure is directed to various compounds and methods of preparation of improved compounds that are capable of functioning as cannabinoid receptor 1 (CB1) antagonists with reduced central nervous system (CNS) side effects. The application is also directed to pharmaceutical compositions containing one or more of these compounds, which may also contain one or more additional therapeutic agents. It is also directed to methods of treatment of various conditions that may be responsive to antagonism of the CB1 receptors, including, but not limited to, metabolic syndromes (including liver disease, obesity, and diabetes).
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: June 30, 2020
    Assignee: Research Triangle Institute
    Inventors: Rangan Maitra, Robert W. Wiethe, Yanan Zhang, George S. Amato
  • DIARYL PURINE DERIVATIVES WITH IMPROVED BIOAVAILABILITY
    Publication number: 20190352305
    Abstract: This disclosure is directed to various compounds and methods of preparation of improved compounds that are capable of functioning as cannabinoid receptor 1 (CB1) antagonists with reduced central nervous system (CNS) side effects. The application is also directed to pharmaceutical compositions containing one or more of these compounds, which may also contain one or more additional therapeutic agents. It is also directed to methods of treatment of various conditions that may be responsive to antagonism of the CB1 receptors, including, but not limited to, metabolic syndromes (including liver disease, obesity, and diabetes).
    Type: Application
    Filed: December 20, 2017
    Publication date: November 21, 2019
    Inventors: Rangan Maitra, Robert W. Wiethe, Yanan Zhang, George S. Amato
  • HETEROCYCLIC APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20190322644
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) with heterocyclic cores and uses of such agonists.
    Type: Application
    Filed: October 11, 2017
    Publication date: October 24, 2019
    Inventors: Scott P. RUNYON, Rangan MAITRA, Sanju NARAYANAN, Kenneth S. REHDER
  • APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20190315693
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Application
    Filed: June 21, 2019
    Publication date: October 17, 2019
    Inventors: Scott P. RUNYON, Rangan MAITRA, Sanju NARAYANAN, James Barnwell THOMAS
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 10377718
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: August 13, 2019
    Assignee: Research Triangle Institute
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 10100059
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: October 16, 2018
    Assignee: Research Triangle Institute
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
  • APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20180265518
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Application
    Filed: May 18, 2018
    Publication date: September 20, 2018
    Inventors: Scott P. RUNYON, Rangan MAITRA, Sanju NARAYANAN, James Barnwell THOMAS, Kenneth S. REHDER, Srinivas OLEPU
  • APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20170166577
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Application
    Filed: December 9, 2016
    Publication date: June 15, 2017
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
  • Peripherally restricted diphenyl purine derivatives
    Patent number: 9458160
    Abstract: The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: October 4, 2016
    Assignee: Research Triangle Institute
    Inventors: Rangan Maitra, Alan Bradley Fulp, Yanan Zhang, Herbert H. Seltzman
  • APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20160207889
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Application
    Filed: June 5, 2015
    Publication date: July 21, 2016
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas
  • PERIPHERALLY RESTRICTED DIPHENYL PURINE DERIVATIVES
    Publication number: 20160046630
    Abstract: The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.
    Type: Application
    Filed: October 26, 2015
    Publication date: February 18, 2016
    Inventors: Rangan Maitra, Alan Bradley Fulp, Yanan Zhang, Herbert H. Seltzman
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: RE49594
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: August 1, 2023
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu