Patents by Inventor Ranjala Ratnayake

Ranjala Ratnayake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT
    Publication number: 20240002396
    Abstract: The instant invention describes macrocyclic compounds having antiproliferation activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders.
    Type: Application
    Filed: October 6, 2021
    Publication date: January 4, 2024
    Applicants: University of Florida Research Foundation, Incorporated, Smithsonian Institution
    Inventors: Hendrik Luesch, Valerie J. Paul, Susan Matthew, Qi-Yin Chen, Ranjala Ratnayake
  • Seaweed extracts, unsaturated aldehydes, and methods of treatment
    Patent number: 9730970
    Abstract: The instant invention relates to seaweed extract compositions, processes for isolation, isolated active agents, and methods of treating disease, disorders and conditions in a subject, including, reactive oxygen species (ROS)-mediated diseases and diseases mediated through the activation of the Nrf2-ARE (antioxidant response element) pathway, including proliferative diseases and disorders, Alzheimer's disease, stroke, and certain diseases and disorders of aging and associated with aging and exposure, by use of the extracts, compounds, and compositions thereof.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: August 15, 2017
    Assignees: University of Florida Research Foundation, Inc., Smithsonian Institution
    Inventors: Hendrik Luesch, Valerie J. Paul, Ranjala Ratnayake
  • SEAWEED EXTRACTS, UNSATURATED ALDEHYDES, AND METHODS OF TREATMENT
    Publication number: 20160051604
    Abstract: The instant invention relates to seaweed extract compositions, processes for isolation, isolated active agents, and methods of treating disease, disorders and conditions in a subject, including, reactive oxygen species (ROS)-mediated diseases and diseases mediated through the activation of the Nrf2-ARE (antioxidant response element) pathway, including proliferative diseases and disorders, Alzheimer's disease, stroke, and certain diseases and disorders of aging and associated with aging and exposure, by use of the extracts, compounds, and compositions thereof.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 25, 2016
    Inventors: Hendrik Luesch, Valerie J. Paul, Ranjala Ratnayake
  • Epoxy-guaiane derivatives and treatment of cancer
    Patent number: 8410292
    Abstract: Disclosed are englerins and derivatives (I) thereof useful in the treatment of a number of cancers, particularly renal cancer, as well as pharmaceutical compositions and method of treating a patient with the use of these derivatives. The englerins, for example Englerin A and Englerin B, can be isolated from the plant Phyllanthus engleri or produced by synthetic methods. An example of the englerin derivative is 2?-chloroenglerin A, which has the structure (II), wherein double bond ‘a’ is E, Z, or a mixture of E and Z.
    Type: Grant
    Filed: December 30, 2008
    Date of Patent: April 2, 2013
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: John A. Beutler, Ranjala Ratnayake, David Covell, Tanya R. Johnson
  • EPOXY-GUAIANE DERIVATIVES AND TREATMENT OF CANCER
    Publication number: 20100286259
    Abstract: Disclosed are englerins and derivatives (I) thereof useful in the treatment of a number of cancers, particularly renal cancer, as well as pharmaceutical compositions and method of treating a patient with the use of these derivatives. The englerins, for example Englerin A and Englerin B, can be isolated from the plant Phyllanthus engleri or produced by synthetic methods. An example of the englerin derivative is 2?-chloroenglerin A, which has the structure (II), wherein double bond ‘a’ is E, Z, or a mixture of E and Z.
    Type: Application
    Filed: December 30, 2008
    Publication date: November 11, 2010
    Applicant: The US, DHHS, NIH
    Inventors: John A. Beutler, Ranjala Ratnayake, David Covell, Tanya R. Johnson