Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media for pharmacology model optimization based on distributed data acquisition. A computer system stores a first pharmacology model associated with a drug dosage model for a particular medication. The computer system receives patient data including pharmacological data and data values for a drug identifier and a pharmacology model identifier. The pharmacological data being associated to drug dosing for the particular medication. The computer system aggregates the received data into a first data set based on the drug identifier value. The computer system optimizes the first pharmacology model using the first data set, thereby generating a second pharmacology model. The computer system provides access to the optimized second pharmacology model.