Patents by Inventor Rao Kolluri

Rao Kolluri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein kinase C inhibitors and uses thereof
    Patent number: 8377924
    Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: February 19, 2013
    Assignee: Rigel Pharmaceuticals Inc.
    Inventors: Rajinder Singh, Huí Li, Haoran Zhao, Rao Kolluri, Kin Tso, John Ramphal, Shihai Gu, Carlos Valdez, Jing Zhang, Emily Stauffer, Matthew Duncton, Salvador Alvarez
  • PROTEIN KINASE C INHIBITORS AND USES THEREOF
    Publication number: 20120022092
    Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: July 21, 2011
    Publication date: January 26, 2012
    Inventors: Sacha Holland, Rao Kolluri, Salvador Alvarez, Matthew Duncton, Rajinder Singh, Jing Zhang, Esteban Masuda
  • PROTEIN KINASE C INHIBITORS AND USES THEREOF
    Publication number: 20110130415
    Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: December 1, 2010
    Publication date: June 2, 2011
    Inventors: Rajinder Singh, Kin Tso, Jing Zhang, Matthew Duncton, Salvador Alvarez, Rao Kolluri, John Ramphal, Sacha Holland
  • Benzisothiazoles useful for treating or preventing HCV infection
    Patent number: 7776847
    Abstract: The present invention relates to benzisothiazoles and pharmaceutical compositions thereof that inhibit replication and/or proliferation of HCV virus. The present invention also relates to the use of the benzisothiazoles and pharmaceutical compositions comprising the compounds to treat or prevent HCV infections.
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: August 17, 2010
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Hui Hong, Eileen Goldstein, Emily Stauffer, Dane Goff, Rao Kolluri, Ihab Darwish, Rajinder Singh, Henry Lu
  • PROTEIN KINASE C INHIBITORS AND USES THEREOF
    Publication number: 20100204208
    Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: January 21, 2010
    Publication date: August 12, 2010
    Inventors: Rajinder Singh, Hui Li, Haoran Zhao, Rao Kolluri, Kin Tso, John Ramphal, Shihai Gu, Carlos Valdez, Jing Zhang, Emily Stauffer, Matthew Duncton, Salvador Alvarez
  • PROTEIN KINASE C INHIBITORS AND USES THEREOF
    Publication number: 20100184755
    Abstract: This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Application
    Filed: January 13, 2010
    Publication date: July 22, 2010
    Inventors: Haoran Zhao, Rao Kolluri, Carlos Valdez, Kin Tso, Rajinder Singh, John Ramphal
  • CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS
    Publication number: 20100130486
    Abstract: The invention encompasses compounds having formula I or II and the compositions and methods using these compounds in the treatment of conditions in which inhibition of PKC and PKD is therapeutically useful.
    Type: Application
    Filed: July 17, 2008
    Publication date: May 27, 2010
    Inventors: Rajinder Singh, Hui Li, Haoran Zhao, Donald Payan, Rao Kolluri, Kin Tso, John Ramphal, Shihai Gu
  • Heterocyclic Anti-Viral Compounds Comprising Metabolizable Moieties And Their Uses
    Publication number: 20060247287
    Abstract: The present invention relates to prodrugs and compositions thereof useful for treating or preventing Hepatitis C virus (HCV) infections. In particular, the present invention relates to prodrugs of substituted diphenyl-, diheteroaryl- and mixed phenyl heteroaryl substituted five-membered heterocycle compounds, compositions comprising the compounds and the use of such compounds and compositions to inhibit HCV replication and/or proliferation as a therapeutic approach towards the treatment and/or prevention of HCV infections in humans and animals.
    Type: Application
    Filed: May 2, 2006
    Publication date: November 2, 2006
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Dane Goff, Ihab Darwish, Rao Kolluri, Henry Lu, Gary Park
  • Benzisothiazoles useful for treating or preventing HCV infection
    Publication number: 20060229294
    Abstract: The present invention relates to benzisothiazoles and pharmaceutical compositions thereof that inhibit replication and/or proliferation of HCV virus. The present invention also relates to the use of the benzisothiazoles and pharmaceutical compositions comprising the compounds to treat or prevent HCV infections.
    Type: Application
    Filed: February 24, 2006
    Publication date: October 12, 2006
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Hui Hong, Eileen Goldstein, Emily Stauffer, Dane Goff, Rao Kolluri, Ihab Darwish, Rajinder Singh, Henry Lu
  • Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses
    Publication number: 20050239751
    Abstract: The present invention relates to substituted prodrug and compositions thereof useful for treating or preventing Hepatitis C virus (HCV) infections. In particular, the present invention relates to prodrugs of substituted diphenyl-, diheteroaryl- and mixed phenyl heteroaryl substituted five-membered heterocycle compounds, compositions comprising the compounds and the use of such compounds and compositions to inhibit HCV replication and/or proliferation as a therapeutic approach towards the treatment and/or prevention of HCV infections in humans and animals.
    Type: Application
    Filed: March 25, 2005
    Publication date: October 27, 2005
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Dane Goff, Rao Kolluri, Ihab Darwish, John Partridge, Robin Cooper, Henry Lu, Gary Park
  • Substituted indoles and their use as hcv inhibitors
    Publication number: 20050215614
    Abstract: The present invention comprises indole-derivatives that are inhibitors of HCV. Composition comprising the compounds in combination with a pharmaceutically acceptable carrier are also disclosed, as are methods of using the compounds and compositions to inhibit HCV infection of a cell, particular in the form of treating HCV infection in a mammal.
    Type: Application
    Filed: October 15, 2003
    Publication date: September 29, 2005
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Ihab Darwish, Rao Kolluri, Sambaiah Thota, Henry Lu