Patents by Inventor Rao S. Bezwada

Rao S. Bezwada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5674921
    Abstract: A radiation-curable prepolymer of a polyurethane endtipped with an hydroxy (acrylate or methacrylate) is disclosed. The polyurethane is derived from the reaction of a polyfunctional isocyanate with a hydrolyzable oligomer of an anhydrous cyclic ester of an hydroxy acid. Crosslinked polymers prepared by irradiating the prepolymers are also disclosed. The crosslinked polymers are bioabsorbable and biocompatible with bodily tissue, yet still maintain the outstanding mechanical properties one would expect from a polyurethane. The prepolymers and crosslinked polymers are especially well-suited for the fabrication of surgical devices, particularly wound closure devices such as surgical staples and clips, in a stereolithography apparatus.
    Type: Grant
    Filed: February 1, 1995
    Date of Patent: October 7, 1997
    Assignee: Ethicon, Inc.
    Inventors: Donald W. Regula, Michael F. Bregen, Stuart L. Cooper, Dennis D. Jamiolkowski, Rao S. Bezwada
  • Patent number: 5653992
    Abstract: A sustained release parenteral composition comprising an admixture of at least one drug to be delivered in a therapeutically effective amount and a bioabsorbable lactone polymer containing one or more lactone monomers that is a liquid at body temperature, provided in an amount effective to sustain or extend the release rate of the drug and a method for administering said composition to an animal.
    Type: Grant
    Filed: April 26, 1995
    Date of Patent: August 5, 1997
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Stephen C. Arnold, Shalaby W. Shalaby, Bernard L. Williams
  • Patent number: 5648088
    Abstract: The present invention describes aliphatic polyoxaesters containing amines and/or amido groups and blends thereof with other polymers that may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The aliphatic polyoxaesters of the present invention have a first divalent repeating unit of formula I:[O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)-- ]Iand a second repeating unit of the formula:[--O--R.sub.12 --].sub.u, XVIand optionally a third repeating unit with a formula selected from the group consisting of:[--O--R.sub.4 --].sub.A, II[--O--R.sub.5 --C(O)--].sub.B, III([--O--R.sub.5 --C(O)].sub.P --O--).sub.L G XIand combinations thereof wherein R.sub.12 contains an internal amine or internal amide group.
    Type: Grant
    Filed: March 5, 1996
    Date of Patent: July 15, 1997
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Dennis D. Jamiolkowski
  • Patent number: 5645850
    Abstract: The present invention describes an aliphatic polyoxaamide polymer and blends thereof that may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The aliphatic polyoxaamide of the present invention have a first divalent repeating unit of formula I:[X--C(O)--C(R.sub.1) (R.sub.2)--O--(R.sub.3)--O--C(R.sub.1) (R.sub.2)--C(O)--] Iand a second repeating unit selected from the group of formulas consisting of:[--Y--R.sub.17 --].sub.T, I[--O--R.sub.5 --C(O)--].sub.B, and III([--O--R.sub.9 --C(O)].sub.P --O--) XIand combinations thereof, wherein X and Y are selected from the group consisting of --O-- and --N(R)--, provided both X and Y are not both --O-- and may be blended with a second polymer that is preferably biocompatable.
    Type: Grant
    Filed: August 7, 1996
    Date of Patent: July 8, 1997
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Dennis D. Jamiolkowski
  • Patent number: 5639851
    Abstract: Absorbable, segmented copolymers of aliphatic polyesters based on lactone monomers lactide, and p-dioxanone are described. The segmented copolymers exhibit a broad range of properties, especially high strength and long elongations. This unique elastomeric behavior makes the copolymers of the present invention useful in a variety of medical device applications, especially adhesion prevention barriers and hemostatic devices.
    Type: Grant
    Filed: October 2, 1995
    Date of Patent: June 17, 1997
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Kevin Cooper
  • Patent number: 5633343
    Abstract: Absorbable, segmented copolymers of aliphatic polyesters based on lactone monomers glycolide, and p-dioxanone are described. The segmented copolymers exhibit a broad range of properties, especially high strength and stiffness, and fast absorption rates and breaking strength retention (BSR) profiles, useful in a variety of medical devices. Most importantly, for suture applications where Vicryl.RTM.-like polyglcolide-polylactide sutures with excellent tensile properties, but shorter BSR profiles than Vicryl.RTM. are needed. The copolymers of the present invention have such properties, making them useful in plastic surgery where faster absorption times would lead to less tissue scarring.
    Type: Grant
    Filed: June 30, 1995
    Date of Patent: May 27, 1997
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Kevin Cooper, Dennis D. Jamiolkowski, Hugh D. Newman, Jr.
  • Patent number: 5631015
    Abstract: A sustained release parenteral composition comprising an admixture of at least one drug to be delivered in a therapeutically effective amount and a bioabsorbable lactone polymer containing one or more lactone monomers that is a liquid at body temperature, provided in an amount effective to sustain or extend the release rate of the drug and a method for administering said composition to an animal.
    Type: Grant
    Filed: May 20, 1996
    Date of Patent: May 20, 1997
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Stephen C. Arnold, Shalaby W. Shalaby, Bernard L. Williams
  • Patent number: 5620698
    Abstract: The present invention describes aliphatic polyoxaesters containing amines and/or amido groups and blends thereof with other polymers that may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The aliphatic polyoxaesters of the present invention have a first divalent repeating unit of formula I:[O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)-- ]Iand a second repeating unit of the formula:[--O--R.sub.12 --].sub.U, XVIand optionally a third repeating unit with a formula selected from the group consisting of:[--O--R.sub.4 --].sub.A, II[--O--R.sub.5 --C(O)--].sub.B, III([--O--R.sub.5 --C(O)].sub.P --O--).sub.L G XIand combinations thereof wherein R.sub.12 contains an internal amine or internal amide group.
    Type: Grant
    Filed: June 14, 1996
    Date of Patent: April 15, 1997
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Dennis D. Jamiolkowski
  • Patent number: 5618552
    Abstract: The present invention describes a new aliphatic polyoxaesters that is bioabsorbable and may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The invention also contemplates a process for producing these polyesters. The aliphatic polyoxaesters of the present invention have a first divalent repeating unit of formula I:[O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)-- ]Iand a second repeating unit selected from the group of formulas consisting of:[--O--R.sub.4 --].sub.A, II[--O--R.sub.5 --C(O)--].sub.B, and III([--O--R.sub.5 --C(O)].sub.P --O--).sub.L G XIand combinations thereof.
    Type: Grant
    Filed: March 5, 1996
    Date of Patent: April 8, 1997
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Dennis D. Jamiolkowski
  • Patent number: 5607687
    Abstract: The present invention describes a new aliphatic polyoxaesters and blends thereof that may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The invention also contemplates a process for producing these polyesters. The aliphatic polyoxaesters of the present invention have a first divalent repeating unit of formula I:[O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1l)(R.sub.2)--C(O)- -] Iand a second repeating unit selected from the group of formulas consisting of:[--O--R.sub.4 --].sub.A, II[--O--R.sub.5 --C(O)--].sub.B, and III([--O--R.sub.5 --C(O)].sub.P --O--).sub.L G XIand combinations thereof. These aliphatic polyoxaesters may be blended with other polymers which are preferably biocompatable.
    Type: Grant
    Filed: March 5, 1996
    Date of Patent: March 4, 1997
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Dennis D. Jamiolkowski
  • Patent number: 5599852
    Abstract: The present invention provides injectable, bioabsorbable microdispersions suitable for use as a soft tissue repair or augmentation material in animals comprising a fluid carrier that is a liquid polymer selected from the group consisting of liquid polymers and a particulate material. Additionally, the present invention also discloses methods of using these microdispersions for tissue augmentation and repair as well as kits which include prefilled containers to facilitate the use of these materials.
    Type: Grant
    Filed: October 18, 1994
    Date of Patent: February 4, 1997
    Assignee: Ethicon, Inc.
    Inventors: Angelo G. Scopelianos, Steven C. Arnold, Rao S. Bezwada, Mark B. Roller, Shawn T. Huxel
  • Patent number: 5597579
    Abstract: The present invention describes an aliphatic polyoxaamide polymer and blends thereof that may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The aliphatic polyoxaamide of the present invention have a first divalent repeating unit of formula I:[X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)-- ]Iand a second repeating unit selected from the group of formulas consisting of:[--Y--R.sub.17 --].sub.T, I[--O--R.sub.5 --C(O)--].sub.B, and II([--O--R.sub.9 --C(O)].sub.P --O--).sub.L G XIand combinations thereof, wherein X and Y are selected from the group consisting of --O-- and --N(R)--, provided both X and Y are not both --O-- and may be blended with a second polymer that is preferably biocompatable.
    Type: Grant
    Filed: March 5, 1996
    Date of Patent: January 28, 1997
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Dennis D. Jamiolkowski
  • Patent number: 5595751
    Abstract: The present invention describes a new aliphatic polyoxaesters that is bioabsorbable and may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The invention also contemplates a process for producing these polyesters. The aliphatic polyoxaesters of the present invention have a first divalent repeating unit of formula I:[O--C(O)--C(R.sub.1) (R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--] Iand a second repeating unit of the formula:[--O--R.sub.12 --].sub.U, XVIand optionally a third repeating unit with a formula selected from the group consisting of:[--O--R.sub.4 --].sub.A, II[--O--R.sub.5 --C(O)--].sub.B, III([--O--R.sub.5 --C(O)].sub.P,--O--).sub.L G XIand combinations thereof wherein R.sub.12 contains an internal amine or internal amide group.
    Type: Grant
    Filed: February 8, 1996
    Date of Patent: January 21, 1997
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Dennis D. Jamiolkowski
  • Patent number: 5470340
    Abstract: A copolymer of p-dioxanone and a prepolymer of p-dioxanone and lactide and/or glycolide, and absorbable surgical devices such as sutures, surgical meshes, surgical staples, hemostatic clips, suture knot clips, and the like made therefrom.
    Type: Grant
    Filed: October 6, 1993
    Date of Patent: November 28, 1995
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Shalaby W. Shalaby, Donald F. Koelmel
  • Patent number: 5468253
    Abstract: Medical devices or components for medical devices formed from bioabsorbable elastomers comprising a random copolymer are disclosed. The random copolymer is a copolymer of from about 30 to about 70 weight percent of: a) .epsilon.-caprolactone, trimethylene carbonate, an ether lactone, or a mixture of these, and b) the balance being substantially glycolide, para-dioxanone, or a mixture of these. The random copolymers surprisingly exhibit elastomeric properties, and the copolymers are bioabsorbable. The combination of physical and biological properties of these elastomeric copolymers are particularly well-suited for numerous medical and surgical applications.
    Type: Grant
    Filed: January 21, 1993
    Date of Patent: November 21, 1995
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Angelo G. Scopelianos
  • Patent number: 5464929
    Abstract: The present invention describes a new aliphatic polyoxaesters that is bioabsorbable and may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The invention also contemplates a process for producing these polyesters. The aliphatic polyoxaesters of the present invention have a first divalent repeating unit of formula I:[O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)-- ]Iand a second repeating unit selected from the group of formulas consisting of: ##STR1## and combinations thereof.
    Type: Grant
    Filed: March 6, 1995
    Date of Patent: November 7, 1995
    Assignee: Ethicon, Inc.
    Inventors: Rao S. Bezwada, Dennis D. Jamiolkowski
  • Patent number: 5442032
    Abstract: This invention provides various copolymers comprising a repeating unit of the chemical formula:(CH.sub.2 CH.sub.2 CH.sub.2 OCH.sub.2 CO.sub.2)and other repeating units having a chemical formula selected from the group consisting of:(CHRCO.sub.2),([CH.sub.2 ].sub.5 CO.sub.2),(CH.sub.2 CH.sub.2 OCH.sub.2 CO.sub.2),(CH.sub.2 CH.sub.2 CH.sub.2 OCO.sub.2), andcombinations of two or mope thereof wherein R is a hydrogen atom or a methyl group and the first repeating unit is less than 45 weight percent of the total weight of the copolymer. This invention also relates to use of these copolymers in the fabrication of absorbable surgical devices such as sutures and as coatings for medical devices.
    Type: Grant
    Filed: March 15, 1994
    Date of Patent: August 15, 1995
    Assignee: Ethicon, Inc.
    Inventors: Steven C. Arnold, Rao S. Bezwada, Alastair W. Hunter
  • Patent number: 5442033
    Abstract: A copolymer of from in the range of from about 55 to about 70 weight percent lactide and from in the range of from about 45 to about 30 mole percent .epsilon.-caprolactone suitable for use in biomedical applications such as drug delivery, coatings for surgical sutures and needles, and lubricants for medical devices.
    Type: Grant
    Filed: November 14, 1994
    Date of Patent: August 15, 1995
    Assignee: Ethicon, Inc.
    Inventor: Rao S. Bezwada
  • Patent number: 5427778
    Abstract: Gel formulations containing polypeptide growth factors having human mitogenic or angiogenic activity are provided. The gel formulations are useful for topical or incisional wound healing for cutaneous wounds, in the anterior chamber of the eye and other ophthalmic wound healing. The gel formulations also comprise a water soluble, pharmaceutically or ophthalmically compatible polymeric material for providing viscosity within various ranges determined by the application of the gel. The gel formulations provide controlled release and increased contact time of the growth factor to the wound site.
    Type: Grant
    Filed: November 10, 1992
    Date of Patent: June 27, 1995
    Assignee: Ethicon, Inc.
    Inventors: Amy L. Finkenaur, Jonathan M. Cohen, Shalaby W. Shalaby, Elisabeth A. Sandoval, Rao S. Bezwada, Richard L. Kronenthal
  • Patent number: 5411554
    Abstract: A cosmetic or prosthetic surgical implant comprising an envelope filled with a liquid bioabsorbable polymer and a process for implanting a cosmetic or prosthetic surgical implant involving the filling of an envelope with a liquid bioabsorbable polymer suitable liquid bioabsorbable polymer include lactone copolymers composed of at least two monomers selected from the group consisting of glycolide, L-lactide, D,L-lactide, 1,4-dioxanone, .epsilon.-caprolactone, 1,5-dioxepan-2-one and trimethylene carbonate and poly(orthoesters) of the formula: ##STR1## where R is a linear or branched alkylene group containing 3 to 10 carbon atoms and R' is a linear or branched alkyl group containing 1 to 10 carbon atoms and n is selected to provide a liquid poly(orthester) at body temperature.
    Type: Grant
    Filed: July 20, 1993
    Date of Patent: May 2, 1995
    Assignee: Ethicon, Inc.
    Inventors: Angelo G. Scopelianos, Rao S. Bezwada, Stephen C. Arnold, Richard D. Gooding