Patents by Inventor Raoul Bonan
Raoul Bonan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10391204Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: GrantFiled: July 21, 2017Date of Patent: August 27, 2019Assignee: BioInspire Technologies, Inc.Inventors: Dorna Hakimimehr, Raoul Bonan
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Publication number: 20190070342Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially nasal applications are provided, wherein the patch comprises a free-standing film containing at least one therapeutic agent selected from corticosteroids, antihistamines, monoclonal antibodies, leukotriene receptor antagonists, anti-inflammatory cytokines, vasoconstrictive agents, and any combination thereof. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and release the therapeutic content in a sustained fashion. The patch may be micronized and administered in a powdered form.Type: ApplicationFiled: November 2, 2018Publication date: March 7, 2019Applicant: BIOINSPIRE TECHNOLOGIES, INC.Inventors: Dorna HAKIMIMEHR, Raoul BONAN, Arthur E. FERDINAND, Bradley CARR
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Publication number: 20170319752Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: ApplicationFiled: July 21, 2017Publication date: November 9, 2017Applicant: BIOINSPIRE TECHNOLOGIES, INC.Inventors: Dorna HAKIMIMEHR, Raoul BONAN
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Patent number: 9713658Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: GrantFiled: September 15, 2016Date of Patent: July 25, 2017Assignee: BioInspire Technologies, Inc.Inventors: Dorna Hakimimehr, Raoul Bonan
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Publication number: 20170000929Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: ApplicationFiled: September 15, 2016Publication date: January 5, 2017Applicant: BIOINSPIRE TECHNOLOGIES, INC.Inventors: Dorna HAKIMIMEHR, Raoul BONAN
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Patent number: 9446103Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: GrantFiled: November 17, 2015Date of Patent: September 20, 2016Assignee: BioInspire Technologies, Inc.Inventors: Dorna Hakimimehr, Raoul Bonan
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Publication number: 20160067318Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: ApplicationFiled: November 17, 2015Publication date: March 10, 2016Applicant: BIOINSPIRE TECHNOLOGIES, INC.Inventors: Dorna HAKIMIMEHR, Raoul BONAN
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Patent number: 9192698Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: GrantFiled: June 30, 2015Date of Patent: November 24, 2015Assignee: BioInspire Technologies, Inc.Inventors: Dorna Hakimimehr, Raoul Bonan
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Publication number: 20150297806Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: ApplicationFiled: June 30, 2015Publication date: October 22, 2015Applicant: BIOINSPIRE TECHNOLOGIES, INC.Inventors: Dorna HAKIMIMEHR, Raoul BONAN
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Patent number: 9072681Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: GrantFiled: October 15, 2013Date of Patent: July 7, 2015Assignee: BioInspire Technologies, Inc.Inventors: Dorna Hakimimehr, Raoul Bonan
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Publication number: 20140046255Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: ApplicationFiled: October 15, 2013Publication date: February 13, 2014Applicant: Bioinspire Technologies, Inc.Inventors: Dorna Hakimimehr, Raoul Bonan
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Patent number: 8563510Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: GrantFiled: September 17, 2010Date of Patent: October 22, 2013Assignee: Bioinspire Technologies, Inc.Inventors: Dorna Hakimimehr, Raoul Bonan
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Patent number: 8529941Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: GrantFiled: September 17, 2010Date of Patent: September 10, 2013Assignee: Bioinspire Technologies, Inc.Inventors: Dorna Hakimimehr, Raoul Bonan
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Patent number: 8012078Abstract: Method and apparatus are disclosed employing ionizing radiation for forming lines of ablation or lesions in cardiac tissue to treat atrial fibrillation or other electrophysiological problems with the heart. The apparatus may include a catheter in which the radiation source is advanced hydraulically after the catheter is in place within the heart. Various fixation devices are also disclosed for fixing the location of the catheter within the heart.Type: GrantFiled: February 22, 2007Date of Patent: September 6, 2011Assignee: Best VascularInventors: Raoul Bonan, Charles E. Larsen, Roelof Trip, Douglas B. Schumer, Jack C. Griffis, III, Andrew L. Lerohl
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Publication number: 20110196186Abstract: Method and apparatus are disclosed employing ionizing radiation. for forming lines of ablation or lesions in cardiac tissue to treat atrial fibrillation or other electrophysiological problems with the heart. The apparatus may include a catheter in which the radiation source is advanced hydraulically after the catheter is in place within the heart. Various fixation devices are also disclosed for fixing the location of the catheter within the heart.Type: ApplicationFiled: April 20, 2011Publication date: August 11, 2011Inventors: RAOUL BONAN, Charles E. Larsen, Roelof Trip, Douglas B. Schumer, Jack C. Griffis, III, Andrew L. Lerohl
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Publication number: 20110071499Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: ApplicationFiled: September 17, 2010Publication date: March 24, 2011Inventors: Dorna Hakimimehr, Raoul Bonan
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Publication number: 20110071498Abstract: Methods and apparatus for a free-standing biodegradable patch suitable for medical applications, especially intravascular, minimally-invasive and intraoperative surgical applications are provided, wherein the patch comprises a free-standing film or device having a mixture of a solid fibrinogen component and a solid thrombin component that, when exposed to an aqueous environment, undergoes polymerization to form fibrin. In alternative embodiments the patch may comprise a solid fibrinogen component, with or without an inorganic calcium salt component. The patch may take a non-adherent form during delivery to a target location within a vessel or tissue, and thereafter may be activated to adhere to vessel wall or tissue, and may include a number of additives, including materials to improve the mechanical properties of the patch, or one or more therapeutic or contrast agents.Type: ApplicationFiled: September 17, 2010Publication date: March 24, 2011Inventors: Dorna Hakimimehr, Raoul Bonan
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Publication number: 20070288000Abstract: The present invention provides methods for indirect imaging of the internal shape and structure of a heart. The invention can be practiced by injecting fluoroscopic contrast medium into the left atrium and ventricle of a heart, and by placing a radiopaque wire marker in the coronary sinus to provide a known reference location while fluoroscopic contrast medium is injected into the chambers of a heart. The invention provides for simultaneously injecting fluoroscopic contrast medium into both ventricles to characterize the ventricular septum and other cardiac structure. When using the disclosed methods, alone or in a combination with other methods and devices, a clinician can take multiple images of a heart in dyastole and systole. These images can be taken from different angles or the same angle and they can be superimposed upon each other to provide the clinician with a good image of the heart structure and the valve annulus.Type: ApplicationFiled: April 19, 2007Publication date: December 13, 2007Applicant: Medtronic Vascular, Inc.Inventor: Raoul Bonan
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Publication number: 20070173812Abstract: Method and apparatus are disclosed employing ionizing radiation for forming lines of ablation or lesions in cardiac tissue to treat atrial fibrillation or other electrophysiological problems with the heart. The apparatus may include a catheter in which the radiation source is advanced hydraulically after the catheter is in place within the heart. Various fixation devices are also disclosed for fixing the location of the catheter within the heart.Type: ApplicationFiled: February 22, 2007Publication date: July 26, 2007Inventors: Raoul Bonan, Charles Larsen, Roelof Trip, Douglas Schumer, Jack Griffis, Andrew Lerohl
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Patent number: 7182725Abstract: Method and apparatus are disclosed employing ionizing radiation for forming lines of ablation or lesions in cardiac tissue to treat atrial fibrillation or other electrophysiological problems with the heart. The apparatus may include a catheter in which the radiation source is advanced hydraulically after the catheter is in place within the heart. Various fixation devices are also disclosed for fixing the location of the catheter within the heart.Type: GrantFiled: September 23, 2002Date of Patent: February 27, 2007Assignee: Best Vascular, Inc.Inventors: Raoul Bonan, Charles E. Larsen, Roelof Trip, Douglas B. Schumer, Jack C. Griffis, III, Andrew L. Lerohl