Patents by Inventor Raoul Kopelman
Raoul Kopelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110091373Abstract: A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and an imaging agent and methods for making and using same.Type: ApplicationFiled: October 21, 2010Publication date: April 21, 2011Applicants: Health Research, Inc., The Research Foundation of State University of New York, Regents of the University of MichiganInventors: Ravindra K. Pandey, Raoul Kopelman, Anurag Gupta, Munawwar Sajjad
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Patent number: 7923984Abstract: A universal, wireless, nano-optical voltmeter comprises an organic core having at least one voltage-sensitive dye and at least one polymeric shell substantially surrounding the organic core. The nano-optical voltmeter can detect electric fields in cells. The nano-optical voltmeter allows three-dimensional E field profiling throughout the entire volume of living cells. The nano-optical voltmeter may be calibrated externally and then applied for E field determinations inside any live cell or cellular compartment, with no further calibration steps.Type: GrantFiled: January 17, 2008Date of Patent: April 12, 2011Assignee: The Regents of the University Of MichiganInventors: Martin A. Philbert, Katherine M. Tyner, Raoul Kopelman
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Publication number: 20100098637Abstract: The present invention generally relates to dye-loaded nanoparticles. In particular, the present invention provides methods for the staining and visualization of tumor and tumor boundaries using dye-loaded nanoparticles.Type: ApplicationFiled: September 23, 2009Publication date: April 22, 2010Applicant: The Regents Of The University Of MichiganInventors: Daniel Orringer, Oren Sagher, Raoul Kopelman, Yong-Eun Koo Lee
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Patent number: 7576334Abstract: A method of measuring fluorophore excited state lifetimes comprising initiating an excitation laser pulse at a dye to excite dye molecules of the dye from a ground state to an excited state and initiating a probing pulse at the dye molecules thereby generating a first set of photoacoustic waves at a first time delay resulting in a first intensity point. The process can be repeated, optionally introducing a second excitation laser pulse, to generate a second set of photoacoustic waves at a second time delay resulting in a second intensity point. The data can be analyzed to determine a slope between the first intensity point and the second intensity point.Type: GrantFiled: March 18, 2008Date of Patent: August 18, 2009Assignee: The Regents of the University of MichiganInventors: Shai Ashkenazi, Raoul Kopelman, Russell S. Witte, Thomas D. Horvath, Gwangseong Kim
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Publication number: 20080297137Abstract: A universal, wireless, nano-optical voltmeter comprises an organic core having at least one voltage-sensitive dye and at least one polymeric shell substantially surrounding the organic core. The nano-optical voltmeter can detect electric fields in cells. The nano-optical voltmeter allows three-dimensional E field profiling throughout the entire volume of living cells. The nano-optical voltmeter may be calibrated externally and then applied for E field determinations inside any live cell or cellular compartment, with no further calibration steps.Type: ApplicationFiled: January 17, 2008Publication date: December 4, 2008Inventors: Martin A. Philbert, Katherine M. Tyner, Raoul Kopelman
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Publication number: 20080230717Abstract: A method of measuring fluorophore excited state lifetimes comprising initiating an excitation laser pulse at a dye to excite dye molecules of the dye from a ground state to an excited state and initiating a probing pulse at the dye molecules thereby generating a first set of photoacoustic waves at a first time delay resulting in a first intensity point. The process can be repeated, optionally introducing a second excitation laser pulse, to generate a second set of photoacoustic waves at a second time delay resulting in a second intensity point. The data can be analyzed to determine a slope between the first intensity point and the second intensity point.Type: ApplicationFiled: March 18, 2008Publication date: September 25, 2008Inventors: Shai Ashkenazi, Raoul Kopelman, Russell S. Witte, Thomas D. Horvath, Gwangseong Kim
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Publication number: 20080220411Abstract: The present invention relates to biological sensors. In particular, the present invention relates to the use of remotely driven nonlinear rotation of particles (e.g., magnetic particles) for detection of cells such as microorganisms (e.g., bacteria and viruses). The present invention further relates to the use of remotely driven nonlinear rotation of particles for measurement of physical properties of a solution (e.g., viscosity).Type: ApplicationFiled: March 6, 2008Publication date: September 11, 2008Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Brandon H. McNaughton, Raoul Kopelman, Ramon Torres-Isea, Roy Clarke
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Publication number: 20060008924Abstract: The present invention relates to modulated (e.g., magnetically modulated) chemical sensors. In particular, the present invention relates to particles comprising fluorescent indicator dyes and methods of using such particles. Magnetic fields and/or Brownian motion modulate an optical property of the particle to distinguish it from background signals. The present invention thus provides improved methods of detecting a wide variety of analytes in fluids, fluid samples, cells and tissues.Type: ApplicationFiled: June 29, 2005Publication date: January 12, 2006Applicant: The Regents of the University of MichiganInventors: Jeffrey Anker, Caleb Behrend, Raoul Kopelman, Brandon McNaughton
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Patent number: 6900891Abstract: Optical fiber sensors and fiberless optical sensors for measuring analytes, and in particular nitric oxide, are described utilizing metals, and more particularly, metal colloids. Proteins (or fragments thereof) with selective binding are immobilized on metal particles. The proteins may be dye-labeled for increased sensitivity.Type: GrantFiled: July 30, 2003Date of Patent: May 31, 2005Assignee: The Regents of the University of MichiganInventors: Raoul Kopelman, Heather Clark, Susan Barker
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Publication number: 20040190813Abstract: Optical fiber sensors and fiberless optical sensors for measuring analytes, and in particular nitric oxide, are described utilizing metals, and more particularly, metal colloids. Proteins (or fragments thereof) with selective binding are immobilized on metal particles. The proteins may be dye-labeled for increased sensitivity.Type: ApplicationFiled: July 30, 2003Publication date: September 30, 2004Applicant: The Regents of the University of MichiganInventors: Raoul Kopelman, Heather Clark, Susan Barker
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Publication number: 20040058458Abstract: The present invention relates to modulated (e.g., magnetically modulated) chemical sensors. In particular, the present invention relates to particles comprising fluorescent indicator dyes and methods of using such particles. Magnetic fields and/or Brownian motion modulate an optical property of the particle to distinguish it from background signals. The present invention thus provides improved methods of detecting a wide variety of analytes in fluids, fluid samples, cells and tissues.Type: ApplicationFiled: April 18, 2003Publication date: March 25, 2004Applicant: The Regents of the University of MichiganInventors: Jeffrey Anker, Eric Monson, Raoul Kopelman, Martin Philbert
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Patent number: 6636652Abstract: Optical fiber sensors and fiberless optical sensors for measuring analytes, and in particular nitric oxide, are described utilizing metals, and more particularly, metal colloids. Proteins (or fragments thereof) with selective binding are immobilized on metal particles. The proteins may be dye-labeled for increased sensitivity. Additionally, metals functionally linked to reporter dyes are described in addition to the incorporation of reference compounds for ratiometric measurements.Type: GrantFiled: August 2, 1999Date of Patent: October 21, 2003Assignee: The Regents of the University of MichiganInventors: Raoul Kopelman, Heather Clark, Susan Barker
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Publication number: 20020155600Abstract: Fiberless optical sensors (plasticized PVC, acrylamide or gold particles) are described having a size ranging from between approximately 1 micrometer and 1 nanometer in diameter. The sensors comprise ionophores useful for the detection of intracellular analytes.Type: ApplicationFiled: April 30, 2002Publication date: October 24, 2002Inventors: Raoul Kopelman, Heather Clark, Eric Monson, Stephen Parus, Martin Philbert, Bjorn Thorsrud
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Patent number: 6379955Abstract: Fiberless optical sensors (plasticized PVC, acrylamide or gold particles) are described having a size ranging from between approximately 1 micrometer and 1 nanometer in diameter. The sensors comprise ionophores useful for the detection of intracellular analytes.Type: GrantFiled: September 20, 2000Date of Patent: April 30, 2002Assignee: Regents of the University of MichiganInventors: Raoul Kopelman, Heather Clark, Eric Monson, Stephen Parus, Martin Philbert, Bjorn Thorsrud
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Patent number: 6331438Abstract: Optical sensor, probe and array devices for detecting chemical biological, and physical analytes. The devices include an analyte-sensitive layer optically coupled to a thin film electroluminescent layer which activates the analyte-sensitive layer to provide an optical response. The optical response varies depending upon the presence of an analyte and is detected by a photodetector and analyzed to determine the properties of the analyte.Type: GrantFiled: November 24, 1999Date of Patent: December 18, 2001Assignees: Iowa State University Research Foundation, Inc., The Regents of the University of MichiganInventors: Jonathan W. Aylott, Zoe Chen-Esterlit, Jon H. Friedl, Raoul Kopelman, Vadim N. Savvateev, Joseph Shinar
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Patent number: 6272262Abstract: Fiber-optic sensors and fiberless sensors are made for measuring analytes, in particular nitric oxide. The sensors contain a compound specific for the analyte such a nitric oxide-binding compound. Fiber-optic sensors contain the compound immobilized on the tip of the fiber. The tip may be coated with an inert coating such as a metal layer and the compound is immobilized on the coating. Nitric oxide-binding compounds include heme-binding proteins, porphyrin group-containing proteins, heme group-containing proteins, dye-labeled porphyrin group-containing proteins and dye-labeled heme group-containing proteins. In a specific embodiment, dye-labeled cytochrome c′ such as fluorescein-labeled cytochrome c′ is immobilized on a fiber tip containing a gold colloid layer. The fiberless sensors are small enough to enter a single mammalian cell relatively non-invasively.Type: GrantFiled: July 6, 1999Date of Patent: August 7, 2001Assignee: The Regents of the University of MichiganInventors: Raoul Kopelman, Heather Clark, Susan Barker
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Patent number: 6143558Abstract: Fiberless optical sensors (plasticized PVC, acrylamide or gold particles) are described having a size ranging from between approximately 1 micrometer and 1 nanometer in diameter. The sensors comprise ionophores useful for the detection of intracellular analytes.Type: GrantFiled: July 8, 1997Date of Patent: November 7, 2000Assignee: The Regents of the University of MichiganInventors: Raoul Kopelman, Heather Clark, Eric Monson, Stephen Parus, Martin Philbert, Bjorn Thorsrud
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Patent number: 6002817Abstract: Optical fiber sensors and fiberless optical sensors for measuring analytes, and in particular nitric oxide, are described utilizing metals, and more particularly, metal colloids. Proteins (or fragments thereof) with selective binding are immobilized on metal particles. The proteins may be dye-labeled for increased sensitivity.Type: GrantFiled: September 29, 1997Date of Patent: December 14, 1999Assignee: The Regents of the University of MichiganInventors: Raoul Kopelman, Heather Clark, Susan Barker
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Patent number: 5627922Abstract: This invention relates generally to the development of and a method of fabricating a fiber optic micro-light source and sensor (50). An optical fiber micro-light source (50) is presented whose aperture is extremely small yet able to act as an intense light source. Light sources of this type have wide ranging applications, including use as micro-sensors (22) in NSOM. Micro-sensor light sources have excellent detection limits as well as photo stability, reversibility, and millisecond response times. Furthermore, a method for manufacturing a micro optical fiber light source is provided. It involves the photo-chemical attachment of an optically active material onto the end surface of an optical fiber cable which has been pulled to form an end with an extremely narrow aperture. More specifically, photopolymerization has been applied as a means to photo-chemically attach an optically active material (60). This process allows significant control of the size of the micro light source (50).Type: GrantFiled: March 2, 1995Date of Patent: May 6, 1997Assignee: Regents of the University of MichiganInventors: Raoul Kopelman, Weihong Tan, Zhong-You Shi
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Patent number: 5362963Abstract: A nanometer dimension light source includes a source of excitation and an active, electrooptic or chemilluminescent material such as crystalline anthracene. The material is introduced into a confined space having molecular dimensions or is shaped to a point of molecular dimensions. The material is surrounded by an insulator such as a glass pipette which also forms the confined space and which also serves as a reflector for radiation produced in the material. An electric field is imposed on the active medium, injecting holes and electrons which recombined to produce light within the small dimensions of the pipette.Type: GrantFiled: November 3, 1993Date of Patent: November 8, 1994Inventors: Raoul Kopelman, Aaron Lewis