Patents by Inventor Raoul Salup

Raoul Salup has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prostate carcinogenesis predictor
    Patent number: 9078915
    Abstract: A method of detecting prostate tumorigenesis in a subject, the method including the steps of (a) obtaining a sample from the prostate of the human subject, (b) detecting quantitatively or semi-quantitatively in the sample a level of expression for PKC-? and (c) comparing the expression level in (b) to a level of expression in a normal control, wherein overexpression of PKC-?, with respect to the control, indicates the presence of prostate cancer in the subject. The present invention is based upon the discovery that PKC-? levels are elevated during prostate tumorigenesis. Furthermore, the proliferation rate of the tumor correlates with the level of PKC-?. The invention also provides methods of treating prostate cancer by administering to the subject a compound that inhibits the expression of PKC-?. The compound can be a small interfering RNA (siRNA) molecule.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: July 14, 2015
    Assignees: University of South Florida, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Mildred Enid Acevedo-Duncan, Hla Y. Win, Raoul Salup
  • PROSTATE CARCINOGENESIS PREDICTOR
    Publication number: 20140065208
    Abstract: A method of detecting prostate tumorigenesis in a subject, the method including the steps of (a) obtaining a sample from the prostate of the human subject, (b) detecting quantitatively or semi-quantitatively in the sample a level of expression for PKC-? and (c) comparing the expression level in (b) to a level of expression in a normal control, wherein overexpression of PKC-?, with respect to the control, indicates the presence of prostate cancer in the subject. The present invention is based upon the discovery that PKC-? levels are elevated during prostate tumorigenesis. Furthermore, the proliferation rate of the tumor correlates with the level of PKC-?. The invention also provides methods of treating prostate cancer by administering to the subject a compound that inhibits the expression of PKC-?. The compound can be a small interfering RNA (siRNA) molecule.
    Type: Application
    Filed: November 8, 2013
    Publication date: March 6, 2014
    Applicants: The United States Government as represented by the Department of Veterans Affairs, UNIVERSITY OF SOUTH FLORIDA
    Inventors: Mildred Enid ACEVEDO-DUNCAN, Hla Y. WIN, Raoul SALUP
  • Prostate carcinogenesis predictor
    Patent number: 8603758
    Abstract: A method of detecting prostate tumorigenesis in a subject, the method including the steps of (a) obtaining a sample from the prostate of the human subject, (b) detecting quantitatively or semi-quantitatively in the sample a level of expression for PKC-? and (c) comparing the expression level in (b) to a level of expression in a normal control, wherein overexpression of PKC-?, with respect to the control, indicates the presence of prostate cancer in the subject. The present invention is based upon the discovery that PKC-? levels are elevated during prostate tumorigenesis. Furthermore, the proliferation rate of the tumor correlates with the level of PKC-?. The invention also provides methods of treating prostate cancer by administering to the subject a compound that inhibits the expression of PKC-?. The compound can be a small interfering RNA (siRNA) molecule.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: December 10, 2013
    Assignees: University of South Florida, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Mildred Acevedo-Duncan, Hla Y. Win, Raoul Salup
  • Prostate Carcinogenesis Predictor
    Publication number: 20120294932
    Abstract: A method of detecting prostate tumorigenesis in a subject, the method including the steps of (a) obtaining a sample from the prostate of the human subject, (b) detecting quantitatively or semi-quantitatively in the sample a level of expression for PKC-? and (c) comparing the expression level in (b) to a level of expression in a normal control, wherein overexpression of PKC-?, with respect to the control, indicates the presence of prostate cancer in the subject. The present invention is based upon the discovery that PKC-? levels are elevated during prostate tumorigenesis. Furthermore, the proliferation rate of the tumor correlates with the level of PKC-?. The invention also provides methods of treating prostate cancer by administering to the subject a compound that inhibits the expression of PKC-?. The compound can be a small interfering RNA (siRNA) molecule.
    Type: Application
    Filed: June 25, 2012
    Publication date: November 22, 2012
    Applicant: University of South Florida
    Inventors: Mildred Acevedo-Duncan, Hla Y. Win, Raoul Salup
  • PROSTATE CARCINOGENESIS PREDICTOR
    Publication number: 20090130195
    Abstract: A method of detecting prostate tumorigenesis in a subject, the method including the steps of (a) obtaining a sample from the prostate of the human subject, (b) detecting quantitatively or semi-quantitatively in the sample a level of expression for PKC-? and (c) comparing the expression level in (b) to a level of expression in a normal control, wherein overexpression of PKC-?, with respect to the control, indicates the presence of prostate cancer in the subject. The present invention is based upon the discovery that PKC-? levels are elevated during prostate tumorigenesis. Furthermore, the proliferation rate of the tumor correlates with the level of PKC-?. The invention also provides methods of treating prostate cancer by administering to the subject a compound that inhibits the expression of PKC-?. The compound can be a small interfering RNA (siRNA) molecule.
    Type: Application
    Filed: October 17, 2008
    Publication date: May 21, 2009
    Inventors: Mildred Acevedo-Duncan, Hla Y. Win, Raoul Salup