Patents by Inventor Raphaël Marcelpoil

Raphaël Marcelpoil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9547801
    Abstract: Methods for chromogen separation-based image analysis are provided, with such methods being directed to quantitative video-microscopy techniques in cellular biology and pathology applications.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: January 17, 2017
    Assignee: TriPath Imaging, Inc.
    Inventors: Raphaël Marcelpoil, Ryan Williams, Cédrick Orny
  • Publication number: 20130301899
    Abstract: Methods for chromogen separation-based image analysis are provided, with such methods being directed to quantitative video-microscopy techniques in cellular biology and pathology applications.
    Type: Application
    Filed: July 19, 2013
    Publication date: November 14, 2013
    Applicant: TRIPATH IMAGING, INC.
    Inventors: Raphaël Marcelpoil, Ryan Williams, Cédrick Orny
  • Patent number: 8492156
    Abstract: Methods for chromogen separation-based image analysis are provided, with such methods being directed to quantitative video-microscopy techniques in cellular biology and pathology applications.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: July 23, 2013
    Assignee: Tripath Imaging, Inc.
    Inventors: Raphaël Marcelpoil, Ryan Williams, Cédrick Orny
  • Patent number: 8486704
    Abstract: Methods for chromogen separation-based image analysis are provided, with such methods being directed to quantitative video-microscopy techniques in cellular biology and pathology applications.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: July 16, 2013
    Assignee: TriPath Imaging, Inc.
    Inventors: Raphaël Marcelpoil, Ryan Williams, Cédrick Orny
  • Patent number: 7989209
    Abstract: Methods for chromogen separation-based image analysis are provided, with such methods being directed to quantitative video-microscopy techniques in cellular biology and pathology applications.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: August 2, 2011
    Assignee: Tripath Imaging, Inc.
    Inventors: Raphaël Marcelpoil, Ryan Williams, Cédrick Orny
  • Patent number: 7899623
    Abstract: Methods and computer program products for evaluating and optimizing one or more markers for use in establishing a prognosis for a patient suffering from a disease are provided. More particularly, the methods include steps for systematically evaluating a number of features that may be extracted from an image of a body sample, such as a histological slide, that has been exposed to one or more biomarkers so as to establish a prognostic decision rule based on one or more of the extracted features such that the decision rule yields a prognosis that is optimally predictive of actual patient outcome. Thus, the methods and computer program products provided yield optimally predictive prognoses to assist clinicians in developing strategies for effective patient care management.
    Type: Grant
    Filed: September 22, 2005
    Date of Patent: March 1, 2011
    Assignee: TriPath Imaging, Inc.
    Inventors: Raphael Marcelpoil, Clark Merrill Whitehead, Timothy J. Fischer
  • Patent number: 7826650
    Abstract: A method of determining an amount of at least one molecular species in a sample from an image of the sample captured by an image acquisition device is provided, each molecular species being indicated by a dye. A dye space representation of a plurality of dyes is formed by orthogonally adding the correspondence tables of the dyes, each correspondence table having a plurality of normalized RGB triplets and incrementally extending from 0% to 100% transmittance. The dye space representation has one dimension for each dye and provides a reference model for a combination of the plurality of dyes. Each pixel of an image of the sample stained with the combination of the plurality of dyes is compared to the reference model, each pixel having a color defined by an RGB triplet, so as to determine an optimal combination of normalized RGB triplets from the respective correspondence tables of the dyes producing the color of the respective pixel.
    Type: Grant
    Filed: September 4, 2009
    Date of Patent: November 2, 2010
    Assignee: TriPath Imaging, Inc.
    Inventors: Raphaël Marcelpoil, Didier Morel
  • Patent number: 7772535
    Abstract: A method of capturing a focused image of a continuously moving slide/objective arrangement is provided. A frame grabber device is triggered to capture an image of the slide through an objective at a first focus level as the slide continuously moves laterally relative to the objective. Alternatingly with triggering the frame grabber device, the objective is triggered to move to a second focus level after capture of the image of the slide. The objective moves in discrete steps, oscillating between minimum and maximum focus levels. The frame grabber device is triggered at a frequency as the slide continuously moves laterally relative to the objective so multiple images at different focus levels overlap, whereby a slide portion is common to each. The image having the maximum contrast value within overlapping images represents an optimum focus level for the slide portion, and thus the focused image. Associated apparatuses and methods are also provided.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: August 10, 2010
    Assignee: TriPath Imaging, Inc.
    Inventors: Bruno Krief, Raphaël Marcelpoil
  • Publication number: 20100067775
    Abstract: Methods for chromogen separation-based image analysis are provided, with such methods being directed to quantitative video-microscopy techniques in cellular biology and pathology applications.
    Type: Application
    Filed: November 18, 2009
    Publication date: March 18, 2010
    Inventors: Raphaël Marcelpoil, Ryan Williams, Cédrick Orny
  • Publication number: 20100067774
    Abstract: Methods for chromogen separation-based image analysis are provided, with such methods being directed to quantitative video-microscopy techniques in cellular biology and pathology applications.
    Type: Application
    Filed: November 18, 2009
    Publication date: March 18, 2010
    Inventors: Raphaël Marcelpoil, Ryan Williams, Cédrick Orny
  • Publication number: 20100061618
    Abstract: Methods for chromogen separation-based image analysis are provided, with such methods being directed to quantitative video-microscopy techniques in cellular biology and pathology applications.
    Type: Application
    Filed: November 18, 2009
    Publication date: March 11, 2010
    Inventors: Raphaël Marcelpoil, Ryan Williams, Cédrick Orny
  • Publication number: 20100054574
    Abstract: A method of determining an amount of at least one molecular species in a sample from an image of the sample captured by an image acquisition device is provided, each molecular species being indicated by a dye. A dye space representation of a plurality of dyes is formed by orthogonally adding the correspondence tables of the dyes, each correspondence table having a plurality of normalized RGB triplets and incrementally extending from 0% to 100% transmittance. The dye space representation has one dimension for each dye and provides a reference model for a combination of the plurality of dyes. Each pixel of an image of the sample stained with the combination of the plurality of dyes is compared to the reference model, each pixel having a color defined by an RGB triplet, so as to determine an optimal combination of normalized RGB triplets from the respective correspondence tables of the dyes producing the color of the respective pixel.
    Type: Application
    Filed: September 4, 2009
    Publication date: March 4, 2010
    Inventors: Raphaël Marcelpoil, Didier Morel
  • Patent number: 7638748
    Abstract: A method of capturing a focused image of a continuously moving slide/objective arrangement is provided. A frame grabber device is triggered to capture an image of the slide through an objective at a first focus level as the slide continuously moves laterally relative to the objective. Alternatingly with triggering the frame grabber device, the objective is triggered to move to a second focus level after capture of the image of the slide. The objective moves in discrete steps, oscillating between minimum and maximum focus levels. The frame grabber device is triggered at a frequency as the slide continuously moves laterally relative to the objective so multiple images at different focus levels overlap, whereby a slide portion is common to each. The image having the maximum contrast value within overlapping images represents an optimum focus level for the slide portion, and thus the focused image. Associated apparatuses and methods are also provided.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: December 29, 2009
    Assignee: TriPath Imaging
    Inventors: Bruno Krief, Raphaël Marcelpoil
  • Publication number: 20090269856
    Abstract: Methods and compositions for evaluating the prognosis of a breast cancer patient, particularly an early-stage breast cancer patient, are provided. The methods of the invention comprise detecting expression of at least one, more particularly at least two, biomarker(s) in a body sample, wherein overexpression of the biomarker or a combination of biomarkers is indicative of breast cancer prognosis. In some embodiments, the body sample is a breast tissue sample, particularly a primary breast tumor sample. The biomarkers of the invention are proteins and/or genes whose overexpression is indicative of either a good or bad cancer prognosis. Biomarkers of interest include proteins and genes involved in cell cycle regulation, DNA replication, transcription, signal transduction, cell proliferation, invasion, proteolysis, or metastasis.
    Type: Application
    Filed: May 14, 2009
    Publication date: October 29, 2009
    Applicant: TriPath Imaging, Inc
    Inventors: Timothy J. Fischer, Clark M. Whitehead, Douglas P. Malinowski, Raphael Marcelpoil, Didier Morel
  • Patent number: 7605356
    Abstract: A method of capturing a focused image of a continuously moving slide/objective arrangement is provided. A frame grabber device is triggered to capture an image of the slide through an objective at a first focus level as the slide continuously moves laterally relative to the objective. Alternatingly with triggering the frame grabber device, the objective is triggered to move to a second focus level after capture of the image of the slide. The objective moves in discrete steps, oscillating between minimum and maximum focus levels. The frame grabber device is triggered at a frequency as the slide continuously moves laterally relative to the objective so multiple images at different focus levels overlap, whereby a slide portion is common to each. The image having the maximum contrast value within overlapping images represents an optimum focus level for the slide portion, and thus the focused image. Associated apparatuses and methods are also provided.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: October 20, 2009
    Assignee: TriPath Imaging, Inc.
    Inventors: Bruno Krief, Raphaël Marcelpoil
  • Patent number: 7602954
    Abstract: A method of determining an amount of at least one molecular species in a sample from an image of the sample captured by an image acquisition device is provided, each molecular species being indicated by a dye. A dye space representation of a plurality of dyes is formed by orthogonally adding the correspondence tables of the dyes, each correspondence table having a plurality of normalized RGB triplets and incrementally extending from 0% to 100% transmittance. The dye space representation has one dimension for each dye and provides a reference model for a combination of the plurality of dyes. Each pixel of an image of the sample stained with the combination of the plurality of dyes is compared to the reference model, each pixel having a color defined by an RGB triplet, so as to determine an optimal combination of normalized RGB triplets from the respective correspondence tables of the dyes producing the color of the respective pixel.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: October 13, 2009
    Assignee: TriPath Imaging, Inc.
    Inventors: Raphaël Marcelpoil, Didier Morel
  • Publication number: 20080273776
    Abstract: A method of capturing a focused image of a continuously moving slide/objective arrangement is provided. A frame grabber device is triggered to capture an image of the slide through an objective at a first focus level as the slide continuously moves laterally relative to the objective. Alternatingly with triggering the frame grabber device, the objective is triggered to move to a second focus level after capture of the image of the slide. The objective moves in discrete steps, oscillating between minimum and maximum focus levels. The frame grabber device is triggered at a frequency as the slide continuously moves laterally relative to the objective so multiple images at different focus levels overlap, whereby a slide portion is common to each. The image having the maximum contrast value within overlapping images represents an optimum focus level for the slide portion, and thus the focused image. Associated apparatuses and methods are also provided.
    Type: Application
    Filed: July 14, 2008
    Publication date: November 6, 2008
    Inventors: Bruno Krief, Raphael Marcelpoil
  • Publication number: 20080272274
    Abstract: A method of capturing a focused image of a continuously moving slide/objective arrangement is provided. A frame grabber device is triggered to capture an image of the slide through an objective at a first focus level as the slide continuously moves laterally relative to the objective. Alternatingly with triggering the frame grabber device, the objective is triggered to move to a second focus level after capture of the image of the slide. The objective moves in discrete steps, oscillating between minimum and maximum focus levels. The frame grabber device is triggered at a frequency as the slide continuously moves laterally relative to the objective so multiple images at different focus levels overlap, whereby a slide portion is common to each. The image having the maximum contrast value within overlapping images represents an optimum focus level for the slide portion, and thus the focused image. Associated apparatuses and methods are also provided.
    Type: Application
    Filed: July 14, 2008
    Publication date: November 6, 2008
    Inventors: Bruno Krief, Raphael Marcelpoil
  • Publication number: 20080272273
    Abstract: A method of capturing a focused image of a continuously moving slide/objective arrangement is provided. A frame grabber device is triggered to capture an image of the slide through an objective at a first focus level as the slide continuously moves laterally relative to the objective. Alternatingly with triggering the frame grabber device, the objective is triggered to move to a second focus level after capture of the image of the slide. The objective moves in discrete steps, oscillating between minimum and maximum focus levels. The frame grabber device is triggered at a frequency as the slide continuously moves laterally relative to the objective so multiple images at different focus levels overlap, whereby a slide portion is common to each. The image having the maximum contrast value within overlapping images represents an optimum focus level for the slide portion, and thus the focused image. Associated apparatuses and methods are also provided.
    Type: Application
    Filed: July 14, 2008
    Publication date: November 6, 2008
    Inventors: Bruno Krief, Raphael Marcelpoil
  • Patent number: 7417213
    Abstract: A method of capturing a focused image of a continuously moving slide/objective arrangement is provided. A frame grabber device is triggered to capture an image of the slide through an objective at a first focus level as the slide continuously moves laterally relative to the objective. Alternatingly with triggering the frame grabber device, the objective is triggered to move to a second focus level after capture of the image of the slide. The objective moves in discrete steps, oscillating between minimum and maximum focus levels. The frame grabber device is triggered at a frequency as the slide continuously moves laterally relative to the objective so multiple images at different focus levels overlap, whereby a slide portion is common to each. The image having the maximum contrast value within overlapping images represents an optimum focus level for the slide portion, and thus the focused image. Associated apparatuses and methods are also provided.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: August 26, 2008
    Assignee: TriPath Imaging, Inc.
    Inventors: Bruno Krief, Raphaël Marcelpoil