Patents by Inventor Raphaël Scharfmann

Raphaël Scharfmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMAN PANCREATIC BETA CELL LINES FOR DIAGNOSTIC OF DIABETES
    Publication number: 20190136196
    Abstract: The present invention relates to a method for preparing commercial scale quantities of human functional Betacells and to the establishment of cell lines. It also relates to a method of diagnosis using Beta cell tumors or cells derived thereof. The method comprises sub-transplantation procedure to enrich the graft in proliferating Betacells, allowing to generate human Betacell lines. Such lines express little amount of insulin and have a gene expression profile that resembles to adult Betacells. In addition, the human Betacell lines are able to normalize glycemia of diabetic mice when transplanted, demonstrating their insulin secretion capabilities.
    Type: Application
    Filed: November 14, 2018
    Publication date: May 9, 2019
    Inventors: Paul CZERNICHOW, Raphaël SCHARFMANN, Philippe RAVASSARD
  • Human pancreatic beta cell lines for diagnostic of diabetes
    Patent number: 10167450
    Abstract: The present invention relates to a method for preparing commercial scale quantities of human functional Betacells and to the establishment of cell lines. It also relates to a method of diagnosis using Beta cell tumors or cells derived thereof. The method comprises sub-transplantation procedure to enrich the graft in proliferating Betacells, allowing to generate human Betacell lines. Such lines express little amount of insulin and have a gene expression profile that resembles to adult Betacells. In addition, the human Betacell lines are able to normalize glycemia of diabetic mice when transplanted, demonstrating their insulin secretion capabilities.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: January 1, 2019
    Assignees: SARL ENDOCELLS, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Paul Czernichow, Raphaël Scharfmann, Philippe Ravassard
  • Method for increasing the pool of Ngn3+ endocrine progenitor cells and pancreatic endocrine cell mass
    Patent number: 8679842
    Abstract: The present invention discloses a method for increasing the pool of Ngn3+ endocrine progenitor cells obtained from stem cells, by contacting said stem cells with a SUR1/Kir6.2 channel inhibitor. The invention also relates to a method for increasing the mass of pancreatic endocrine cells, in particular of ? cells. The invention further concerns a method for treating diabetes.
    Type: Grant
    Filed: March 2, 2010
    Date of Patent: March 25, 2014
    Assignee: Assistance Publique—Hopitaux de Paris
    Inventors: Michel Polak, Raphaël Scharfmann, Samia Zertal-Zidani
  • METHOD FOR INCREASING THE POOL OF NGN3+ ENDOCRINE PROGENITOR CELLS AND PANCREATIC ENDOCRINE CELL MASS
    Publication number: 20110319870
    Abstract: The present invention discloses a method for increasing the pool of Ngn3+ endocrine progenitor cells obtained from stem cells, by contacting said stem cells with a SUR1/Kir6.2 channel inhibitor. The invention also relates to a method for increasing the mass of pancreatic endocrine cells, in particular of ? cells. The invention further concerns a method for treating diabetes.
    Type: Application
    Filed: March 2, 2010
    Publication date: December 29, 2011
    Applicant: ASSISTANCE PUBLIQUE- HOPITAUX DE PARIS
    Inventors: Michel Polak, Raphaël Scharfmann, Samia Zertal-Zidani