Abstract: A fan is described, with the aid of which a volume flow and/or a mass flow of a medium moved by the fan (1) can be determined. This fan comprises an electric motor (2) and an impeller (3) driven by the electric motor (2), wherein the impeller (3) moves a gaseous medium in a media flow from an inflow side (5) to an outflow side (7). The fan additionally comprises a pressure sensor system, a speed ascertainment system, and an evaluation unit. The pressure sensor system is designed to ascertain an actual pressure difference (?p*) between a first region (10) and a second region (13), wherein the first region (10) and/or the second region (13) is/are formed in the electric motor (2), wherein a pressure (pA) prevails in the first region (10), which corresponds to a pressure (p1) present on the inflow side, wherein a pressure (pB) prevails in the second region (13), which corresponds to a pressure (p2) present on the outflow side.

Abstract: A method is used to identify impending or previously occurring condensation on/in electric motors, in particular on/in electric motors as a component of fans or fan groups. It includes the following method steps: Determining component temperatures, preferably surface temperatures on the electronics, on/in the motor, on/in the fan, or on/in fan groups; Determining the dew point temperature or individual dew point temperatures on the electronics, in/on the motor, fan, or on/in fan groups; Comparing the respective component temperature with the respective dew point temperature and concluding a formation of condensation has already taken place or is imminent when the component temperature approaches the dew point temperature or when the dew point temperature is undershot. A further method serves to prevent the formation of condensate and/or to eliminate/remove condensate on/in electric motors, in particular on/in electric motors as a component of fans or fan groups.

Abstract: Technologies for the prevention and/or treatment of nosocomial infections.

Abstract: The invention relates to immunogenic polysaccharide-protein conjugates comprising a capsular polysaccharide (CP) from Streptococcus agalactiae, commonly referred to as group B streptococcus (GBS), and a carrier protein, wherein the CP is selected from the group consisting of serotypes Ia, Ib, II, III, IV, V, VI, VII, VIII, and IX, and wherein the CP has a sialic acid level of greater than about 60%. The invention also relates to methods of making the conjugates and immunogenic compositions comprising the conjugates. The invention further relates to methods for inducing an immune response in subjects against GBS and/or for reducing or preventing invasive GBS disease in subjects using the compositions disclosed herein. The resulting antibodies can be used to treat or prevent GBS infection via passive immunotherapy.

Abstract: Technologies for the prevention and/or treatment of nosocomial infections.

Abstract: A method for determining a state of an electric motor having a stator (2) and a rotor (3) rotatably mounted relative to the stator (2) is disclosed. Due to a rotary motion of the rotor (3), a pressure difference (p) relative to an environment (15) of the electric motor (1, 1?, 1?, 1??) is caused in an air space (16) inside the electric motor (1, 1?, 1?, 1??). Here, in a normal state of the electric motor (1, 1?, 1?, 1??), the pressure difference depends on an actual rotational speed (n) of the rotor (3). A corresponding electric motor suitable for carrying out this method is disclosed, wherein the electric motor may be part of a fan.

Abstract: The invention relates to a method for determining a fluid conveying parameter, a fluid conveying device, particularly for determining a volumetric flow, comprising the steps of Determining excitation information for mechanical excitation of at least one fluid conveying element of the fluid conveying device in at least one spatial direction by at least one first sensor means, Providing operating information, comprising at least a value of an operating variable of the fluid conveying device by means of a providing means, Analyzing the information provided and determined, Determining a fluid conveying parameter, particularly a volumetric flow, of the fluid conveying device based on the analyzed information.

Abstract: A fan is described, with the aid of which a volume flow and/or a mass flow of a medium moved by the fan (1) can be determined. This fan comprises an electric motor (2) and an impeller (3) driven by the electric motor (2), wherein the impeller (3) moves a gaseous medium in a media flow from an inflow side (5) to an outflow side (7). The fan additionally comprises a pressure sensor system, a speed ascertainment system, and an evaluation unit. The pressure sensor system is designed to ascertain an actual pressure difference (?p*) between a first region (10) and a second region (13), wherein the first region (10) and/or the second region (13) is/are formed in the electric motor (2), wherein a pressure (pA) prevails in the first region (10), which corresponds to a pressure (p1) present on the inflow side, wherein a pressure (pB) prevails in the second region (13), which corresponds to a pressure (p2) present on the outflow side.

Abstract: Technologies for the prevention and/or treatment of nosocomial infections.

Abstract: A method is used to identify impending or previously occurring condensation on/in electric motors, in particular on/in electric motors as a component of fans or fan groups. It includes the following method steps: Determining component temperatures, preferably surface temperatures on the electronics, on/in the motor, on/in the fan, or on/in fan groups; Determining the dew point temperature or individual dew point temperatures on the electronics, in/on the motor, fan, or on/in fan groups; Comparing the respective component temperature with the respective dew point temperature and concluding a formation of condensation has already taken place or is imminent when the component temperature approaches the dew point temperature or when the dew point temperature is undershot. A further method serves to prevent the formation of condensate and/or to eliminate/remove condensate on/in electric motors, in particular on/in electric motors as a component of fans or fan groups.

Abstract: The invention relates to a method for determining a fluid conveying parameter, a fluid conveying device, particularly for determining a volumetric flow, comprising the steps of Determining excitation information for mechanical excitation of at least one fluid conveying element of the fluid conveying device in at least one spatial direction by at least one first sensor means, Providing operating information, comprising at least a value of an operating variable of the fluid conveying device by means of a providing means, Analyzing the information provided and determined, Determining a fluid conveying parameter, particularly a volumetric flow, of the fluid conveying device based on the analyzed information.

Abstract: Longer chain antigenic O-polysaccharide chains for use as a hapten in conjugate vaccines can be produced in a controlled manner using recombinant Gram-negative bacteria that overexpress native or heterologous genes of the wzz family, for example wzzB. Bacteria expressing a chosen wzz gene have modified O-polysaccharide chain lengths, allowing the bacteria to produce lipopolysaccharides having the longer O-polysaccharides. The LPS produced by the bacteria can be hydrolyzed to form core-O-polysaccharide molecules that can be conjugated to a carrier molecule, for example flagellin, to produce a vaccine. The invention also provides recombinant bacteria producing the longer chain O-polysaccharides, the polysaccharide molecules, themselves, conjugated vaccines comprising the O-polysaccharides, pharmaceutical compositions and kits.

Abstract: The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked to one or more Klebsiella surface polysaccharide antigens, such as Klebsiella pneumoniae O polysaccharide from serovars O1, O2a, O2a,c, O3, O4, O5, O7, O8 and O12. The present invention also provides serovar reagent strains to produce the conjugates and vaccine compositions and methods of inducing an immune response with the conjugates and vaccine compositions.

Abstract: The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked to one or more Klebsiella surface polysaccharide antigens, such as Klebsiella pneumoniae O polysaccharide from serovars O1, O2a, O2a,c, O3, O4, O5, O7, O8 and O12. The present invention also provides serovar reagent strains to produce the conjugates and vaccine compositions and methods of inducing an immune response with the conjugates and vaccine compositions.

Abstract: The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked to one or more Klebsiella surface polysaccharide antigens, such as Klebsiella pneumoniae O polysaccharide from serovars O1, O2a, O2a,c, O3, O4, O5, O7, O8 and 012. The present invention also provides serovar reagent strains to produce the conjugates and vaccine compositions and methods of inducing an immune response with the conjugates and vaccine compositions.

Abstract: Longer chain antigenic O-polysaccharide chains for use as a hapten in conjugate vaccines can be produced in a controlled manner using recombinant Gram-negative bacteria that overexpress native or heterologous genes of the wzz family, for example wzzB. Bacteria expressing a chosen wzz gene have modified O-polysaccharide chain lengths, allowing the bacteria to produce lipopolysaccharides having the longer O-polysaccharides. The LPS produced by the bacteria can be hydrolyzed to form core-O-polysaccharide molecules that can be conjugated to a carrier molecule, for example flagellin, to produce a vaccine. The invention also provides recombinant bacteria producing the longer chain O-polysaccharides, the polysaccharide molecules, themselves, conjugated vaccines comprising the O-polysaccharides, pharmaceutical compositions and kits.

Abstract: The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked to one or more Klebsiella surface polysaccharide antigens, such as Klebsiella pneumoniae O5 polysaccharide from serovars O1, O2a, O2a,c, O3, O4, O5, O7, O8 and 012. The present invention also provides serovar reagent strains to produce the conjugates and vaccine compositions and methods of inducing an immune response with the conjugates and vaccine compositions.

Abstract: The present invention is drawn to attenuated Salmonella serovar strains S. Typhimurium and S. Enteritidis, conjugate vaccines derived from these attenuated strains of S. Typhimurium and S. Enteritidis, comprising an O polysaccharide covalently linked to a flagellin protein, and methods for inducing an immune response in a subject comprising administering the attenuated strains and/or the conjugate vaccines of the invention.

Abstract: The present invention is drawn to multivalent Salmonella enterica serovar conjugate vaccines comprising conjugates of S. Typhimurium, S. Enteritidis, S. Choleraesuis, S. Typhi, S. Paratyphi A and optionally S. Paratyphi B, wherein the conjugates comprise a hapten antigen and a carrier antigen, wherein at least one of the hapten antigens or carrier antigens is characteristic of the Salmonella enterica serovar. The present invention also provides Salmonella enterica serovar reagent strains to produce the multivalent conjugate vaccines and attenuated Salmonella enterica serovars for use as vaccines.

Abstract: The present invention is drawn to attenuated Salmonella serovar strains S. Typhimurium and S. Enteritidis, conjugate vaccines derived from these attenuated strains of S. Typhimurium and S. Enteritidis, comprising an O polysaccharide covalently linked to a flagellin protein, and methods for inducing an immune response in a subject comprising administering the attenuated strains and/or the conjugate vaccines of the invention.