Abstract: A method of delivering and deploying a valve prosthesis includes delivering the valve prosthesis disposed in a delivery catheter to a native valve, proximally retracting a delivery catheter tube of the delivery catheter such that three engagement arms of a support of the valve prosthesis are released from the delivery catheter tube and flare outwardly while an inflow frame portion of the support remains within a distal portion of the delivery catheter, and distally advancing the distal portion of the delivery catheter such that the inflow frame portion is released from the distal portion.

Abstract: Embodiments of the present disclosure are directed to blood-flow regulation systems and associated methods, and, in some embodiments, includes an adjustable blood flow regulation device that includes an inner tube, an expandable member 2020/121309 coupled to the inner tube, a proximal control handle that includes a controller operatively coupled to the member and configured to control expansion of the member, and a downstream tip member coupled to a distal portion of the inner tube which is distal to the member. The tip member is coupled to a first fluid pressure sensor. A second fluid pressure sensor is coupled to a portion of the inner tube proximal to the member.

Abstract: A method for lacerating heart tissue including introducing a device that includes a support frame and a heart tissue cutting assembly in contracted orientations to a heart, expanding the support frame and the heart tissue cutting assembly, first piercing the heart tissue with a pointed sharp tip of a cutting element of the heart tissue cutting assembly, and afterwards axially moving the heart tissue cutting assembly to lacerate heart tissue located between the cutting element and a blade protector.

Abstract: A transcatheter valve laceration device (10, 100) includes a leaflet support frame (12, 112) and a leaflet cutting assembly (14, 114), both of which are movably mounted on a guiding structure (16, 116) and movable between contracted and expanded orientations. In the expanded orientation, a blade protector (24, 124) of the leaflet support frame (12, 112) is positioned over a cutting element (36, 136) of the leaflet cutting assembly (14, 114).

Abstract: A method of delivering and deploying a valve prosthesis includes delivering the valve prosthesis disposed in a delivery catheter to a native valve, proximally retracting a delivery catheter tube of the delivery catheter such that three engagement arms of a support of the valve prosthesis are released from the delivery catheter tube and flare outwardly while an inflow frame portion of the support remains within a distal portion of the delivery catheter, and distally advancing the distal portion of the delivery catheter such that the inflow frame portion is released from the distal portion.

Abstract: A method for rotationally aligning a valve prosthesis using imaging identifiers includes delivering the valve prosthesis in a collapsed configuration in a catheter to a vicinity of a functioning native heart valve of a heart of the subject using a retrograde approach, generating an image of the functioning native heart valve and the valve prosthesis, rotationally aligning engagement arms of the valve prosthesis with sinuses of the functioning native heart valve using at least one of the imaging identifiers of the heart valve prosthesis visible in the image.

Abstract: Prosthetic ring valve assemblies are disclosed. A prosthetic valve ring assembly includes an outer tube and a plurality of anchors. The outer tube includes a plurality of windows. The plurality of anchors are positioned inside the outer tube and about a perimeter of the outer tube. The plurality of anchors are configured to be emitted from the plurality of windows in order to anchor the prosthetic valve ring assembly to annulus tissue of a patient.

Abstract: A blood flow reducing assembly includes a catheter shaft and an expandable occlusion member assembled with the catheter shaft. The expandable occlusion member includes foldable protrusions. One or more manipulation members are connected to the foldable protrusions and operative to move the foldable protrusions closer to or further away from one other. Movement of the foldable protrusions modifies occlusion ability of the foldable protrusions.

Abstract: A medical device includes a flexible cannula that includes an internal tube having a proximal end and a distal end and a series of slits cut along a length thereof between the proximal and the distal ends, and an outer jacket softer than the inner tube. Discrete portions of the outer tube are connected to the inner tube along a longitudinal axis of the cannula. Areas at which there is no connection between the outer jacket and the inner tube allow some relative movement between the outer jacket and the inner tube, resulting in increased flexibility of the cannula.

Abstract: A method of delivering and deploying a valve prosthesis includes delivering the valve prosthesis disposed in a delivery catheter to a native valve, proximally retracting a delivery catheter tube of the delivery catheter such that three engagement arms of a support of the valve prosthesis are released from the delivery catheter tube and flare outwardly while an inflow frame portion of the support remains within a distal portion of the delivery catheter, and distally advancing the distal portion of the delivery catheter such that the inflow frame portion is released from the distal portion.

Abstract: A method for rotationally aligning a valve prosthesis using imaging identifiers includes delivering the valve prosthesis in a collapsed configuration in a catheter to a vicinity of a functioning native heart valve of a heart of the subject using a retrograde approach, generating an image of the functioning native heart valve and the valve prosthesis, rotationally aligning engagement arms of the valve prosthesis with sinuses of the functioning native heart valve using at least one of the imaging identifiers of the heart valve prosthesis visible in the image.

Abstract: A method for rotationally aligning a valve prosthesis using imaging identifiers includes delivering the valve prosthesis in a collapsed configuration in a catheter to a vicinity of a functioning native heart valve of a heart of the subject using a retrograde approach, generating an image of the functioning native heart valve and the valve prosthesis, rotationally aligning engagement arms of the valve prosthesis with sinuses of the functioning native heart valve using at least one of the imaging identifiers of the heart valve prosthesis visible in the image.

Abstract: Embodiments of the present disclosure are directed to blood-flow regulation systems and associated methods, and, in some embodiments, includes an adjustable blood flow regulation device that includes an inner tube, an expandable member coupled to the inner tube, a proximal control handle that includes a controller operatively coupled to the member and configured to control expansion of the member, and a downstream tip member coupled to a distal portion of the inner tube which is distal to the member. The tip member is coupled to a first fluid pressure sensor. A second fluid pressure sensor is coupled to a portion of the inner tube proximal to the member.

Abstract: A prosthetic heart valve having identifiers for aiding in radiographic positioning is described.

Abstract: Prosthetic ring valve assemblies are disclosed. A prosthetic valve ring assembly includes an outer tube and a plurality of anchors. The outer tube includes a plurality of windows. The plurality of anchors are positioned inside the outer tube and about a perimeter of the outer tube. The plurality of anchors are configured to be emitted from the plurality of windows in order to anchor the prosthetic valve ring assembly to annulus tissue of a patient.

Abstract: A method of delivering and deploying a valve prosthesis includes delivering the valve prosthesis disposed in a delivery catheter to a native valve, proximally retracting a delivery catheter tube of the delivery catheter such that three engagement arms of a support of the valve prosthesis are released from the delivery catheter tube and flare outwardly while an inflow frame portion of the support remains within a distal portion of the delivery catheter, and distally advancing the distal portion of the delivery catheter such that the inflow frame portion is released from the distal portion.

Abstract: A valve prosthesis includes a support and a prosthetic valve coupled to the support. The support includes three engagement arms that meet one another at three respective junctures. The engagement arms are shaped so as to define three peak complexes at the three respective junctures and three troughs, each trough disposed between two of the peak complexes. The support further includes three support arms, each support arm having a first end coupled to a respective engagement arm between a respective trough of the respective engagement arm and a first one of the three respective junctures and a second end coupled to the respective engagement arm between the respective trough and a second one of the three respective junctures.

Abstract: A method of delivering and deploying a valve prosthesis includes delivering the valve prosthesis disposed in a delivery catheter to a native valve, proximally retracting a delivery catheter tube of the delivery catheter such that three engagement arms of a support of the valve prosthesis are released from the delivery catheter tube and flare outwardly while an inflow frame portion of the support remains within a distal portion of the delivery catheter, and distally advancing the distal portion of the delivery catheter such that the inflow frame portion is released from the distal portion.

Abstract: A valve prosthesis includes a support and a prosthetic valve coupled to the support. The support includes three engagement arms that meet one another at three respective junctures. The engagement arms are shaped so as to define three peak complexes at the three respective junctures and three troughs, each trough disposed between two of the peak complexes. The support further includes three support arms, each support arm having a first end coupled to a respective engagement arm between a respective trough of the respective engagement arm and a first one of the three respective junctures and a second end coupled to the respective engagement arm between the respective trough and a second one of the three respective junctures.

Abstract: A prosthesis is provided for implantation at a native semilunar valve of a native valve complex, the native valve complex having three semilunar sinuses and three native commissures. The prosthesis includes a valve prosthesis support, which comprises a support structure comprising exactly three engagement arms that meet one another at three respective junctures. The engagement arms are shaped so as define three peak complexes at the three respective junctures, and three trough complexes, each of which is between two of the peak complexes. Upon implantation of the prosthesis, each of the engagement arms is at least partially disposed within a respective one of the semilunar sinuses, such that each of the peak complexes is disposed distal to and in rotational alignment with a respective one of the native commissures, and each of the trough complexes is disposed at least partially within the respective one of the semilunar sinuses.