Abstract: A balloon for a perfusion balloon catheter may include a flexible envelope and a spine structure arranged within the envelope. The envelope may define at least two lobes that are disposed mutually spaced angularly about a central longitudinal axis and that project radially, when the envelope is expanded under internal fluid pressure, to define a plurality of longitudinal perfusion channels outside the envelope between the at least two lobes. The spine structure may extend outwardly with respect to the central longitudinal axis to join the envelope at a plurality of junctions disposed angularly between the at least two lobes in alignment with the plurality of perfusion channels. The spine structure may define a longitudinally-extending spine channel that surrounds the central longitudinal axis.

Abstract: A device for the collection of oral fluid from a subject's oral cavity may include a sample-collecting mouthpiece and a one-way valve. The mouthpiece may include a collecting chamber, introducible into the oral cavity of the subject for collecting oral fluid, and a resiliently deformable wall section defining at least part of the collecting chamber such that compression of the resiliently deformable wall forcibly expels a collected fluid from the collecting chamber via a collecting chamber outlet. The one-way valve may be in fluid communication with the collecting chamber outlet and may allow fluid to be displaced from the device following compression of the resiliently deformable wall but prevents ambient air flowing back through the valve into the device.