Patents by Inventor Raphael Bueno
Raphael Bueno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230172635Abstract: Embodiments of the invention provide a system and method for resecting a tissue mass. The system for resecting a tissue mass includes a first sensor for measuring a signal corresponding to the position and orientation of the tissue mass. The first sensor is dimensioned to fit inside of or next to the tissue mass. The system also includes a second sensor attached to a surgical instrument configured to measure the position and orientation of the surgical instrument. A controller is in communication with the first sensor and the second sensor, and the controller executes a stored program to calculate a distance between the first sensor and the second sensor. Accordingly, visual, auditory, haptic or other feedback is provided to the clinician to guide the surgical instrument to the surgical margin.Type: ApplicationFiled: December 14, 2022Publication date: June 8, 2023Inventors: Raphael BUENO, Jayender JAGADEESAN, Alan D. LUCAS
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Publication number: 20230172636Abstract: Embodiments of the invention provide a system and method for resecting a tissue mass. The system for resecting a tissue mass includes a first sensor for measuring a signal corresponding to the position and orientation of the tissue mass. The first sensor is dimensioned to fit inside of or next to the tissue mass. The system also includes a second sensor attached to a surgical instrument configured to measure the position and orientation of the surgical instrument. A controller is in communication with the first sensor and the second sensor, and the controller executes a stored program to calculate a distance between the first sensor and the second sensor. Accordingly, visual, auditory, haptic or other feedback is provided to the clinician to guide the surgical instrument to the surgical margin.Type: ApplicationFiled: December 14, 2022Publication date: June 8, 2023Inventors: Raphael BUENO, Jayender JAGADEESAN, Alan D. LUCAS
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Publication number: 20220273340Abstract: Embodiments of the invention provide a system and method for resecting a tissue mass. The system for resecting a tissue mass includes a first sensor for measuring a signal corresponding to the position and orientation of the tissue mass. The first sensor is dimensioned to fit inside of or next to the tissue mass. The system also includes a second sensor attached to a surgical instrument configured to measure the position and orientation of the surgical instrument. A controller is in communication with the first sensor and the second sensor, and the controller executes a stored program to calculate a distance between the first sensor and the second sensor. Accordingly, visual, auditory, haptic or other feedback is provided to the clinician to guide the surgical instrument to the surgical margin.Type: ApplicationFiled: February 1, 2022Publication date: September 1, 2022Inventors: Raphael BUENO, Jayender JAGADEESAN, Alan D. LUCAS
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Publication number: 20220168046Abstract: Embodiments of the invention provide a system and method for resecting a tissue mass. The system for resecting a tissue mass includes a surgical instrument and a first sensor for measuring a signal corresponding to the position and orientation of the tissue mass. The first sensor is dimensioned to fit insider or next to the tissue mass. The system also includes a second sensor attached to the surgical instrument configured to measure the position and orientation of the surgical instrument. The second sensor is configured to receive the signal from the first sensor. A controller is in communication with the first sensor and/or the second sensor, and the controller executes a stored program to calculate a distance between the first sensor and the second sensor. Accordingly, visual, auditory, haptic or other feedback is provided to the clinician to guide the surgical instrument to the surgical margin.Type: ApplicationFiled: July 1, 2021Publication date: June 2, 2022Inventors: Raphael Bueno, Jayender Jagadeesan, Ferenc A. Jolesz
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Patent number: 11246666Abstract: Embodiments of the invention provide a system and method for resecting a tissue mass. The system for resecting a tissue mass includes a surgical instrument and a first sensor for measuring a signal corresponding to the position and orientation of the tissue mass. The first sensor is dimensioned to fit inside or next to the tissue mass. The system also includes a second sensor attached to the surgical instrument configured to measure the position and orientation of the surgical instrument. The second sensor is configured to receive the signal from the first sensor. A controller is in communication with the first sensor and/or the second sensor, and the controller executes a stored program to calculate a distance between the first sensor and the second sensor. Accordingly, visual, auditory, haptic or other feedback is provided to the clinician to guide the surgical instrument to the surgical margin.Type: GrantFiled: September 5, 2014Date of Patent: February 15, 2022Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Raphael Bueno, Jayender Jagadeesan, Ferenc A. Jolesz
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Patent number: 11234732Abstract: Embodiments of the invention provide a system and method for resecting a tissue mass. The system for resecting a tissue mass includes a first sensor for measuring a signal corresponding to the position and orientation of the tissue mass. The first sensor is dimensioned to fit inside of or next to the tissue mass. The system also includes a second sensor attached to a surgical instrument configured to measure the position and orientation of the surgical instrument. A controller is in communication with the first sensor and the second sensor, and the controller executes a stored program to calculate a distance between the first sensor and the second sensor. Accordingly, visual, auditory, haptic or other feedback is provided to the clinician to guide the surgical instrument to the surgical margin.Type: GrantFiled: October 16, 2020Date of Patent: February 1, 2022Assignees: The Brigham and Women's Hospital, Inc., Navigation Sciences, Inc.Inventors: Raphael Bueno, Jayender Jagadeesan, Alan D. Lucas
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Publication number: 20210386449Abstract: Embodiments of the invention provide a system and method for resecting a tissue mass. The system for resecting a tissue mass includes a first sensor for measuring a signal corresponding to the position and orientation of the tissue mass. The first sensor is dimensioned to fit inside of or next to the tissue mass. The system also includes a second sensor attached to a surgical instrument configured to measure the position and orientation of the surgical instrument. A controller is in communication with the first sensor and the second sensor, and the controller executes a stored program to calculate a distance between the first sensor and the second sensor. Accordingly, visual, auditory, haptic or other feedback is provided to the clinician to guide the surgical instrument to the surgical margin.Type: ApplicationFiled: October 16, 2020Publication date: December 16, 2021Inventors: Raphael BUENO, Jayender JAGADEESAN, Alan D. LUCAS
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Patent number: 11058494Abstract: Embodiments of the invention provide a system and method for resecting a tissue mass. The system for resecting a tissue mass includes a surgical instrument and a first sensor for measuring a signal corresponding to the position and orientation of the tissue mass. The first sensor is dimensioned to fit insider or next to the tissue mass. The system also includes a second sensor attached to the surgical instrument configured to measure the position and orientation of the surgical instrument. The second sensor is configured to receive the signal from the first sensor. A controller is in communication with the first sensor and/or the second sensor, and the controller executes a stored program to calculate a distance between the first sensor and the second sensor. Accordingly, visual, auditory, haptic or other feedback is provided to the clinician to guide the surgical instrument to the surgical margin.Type: GrantFiled: March 11, 2016Date of Patent: July 13, 2021Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Raphael Bueno, Jayender Jagadeesan, Ferenc A. Jolesz
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Publication number: 20160348178Abstract: The invention provides a comprehensive, rapid, unbiased, and accurate method for identifying and/or discovering disease-associated genetic variations, e.g., disease-associated variations. The present invention further provides novel disease-associated genetic variations for use as genetic markers of disease, e.g., cancer. The invention further provides methods for assessing an individual's risk for developing a disease, e.g., cancer, by detecting the presence the novel disease-associated genetic variations of the invention.Type: ApplicationFiled: August 18, 2015Publication date: December 1, 2016Inventors: David J. Sugarbaker, Raphael Bueno
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Patent number: 9446050Abstract: The present invention provides that Ras-like, estrogen-regulated, growth inhibitor (RERG) is a malignant mesothelioma biomarker of clinical course and treatment sensitivity and, itself a target for mesothelioma treatment. A low RERG level in a mesothelioma subject indicates poor prognosis. Analyzing RERG expression level along can help mesothelioma patients make treatment choices. Furthermore, mesothelioma can be treated by modulating RERG activity, for example, with treatment with estrogen or estrogen-like agents.Type: GrantFiled: October 24, 2012Date of Patent: September 20, 2016Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Raphael Bueno, David Sugarbaker
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Publication number: 20160213431Abstract: Embodiments of the invention provide a system and method for resecting a tissue mass. The system for resecting a tissue mass includes a surgical instrument and a first sensor for measuring a signal corresponding to the position and orientation of the tissue mass. The first sensor is dimensioned to fit inside or next to the tissue mass. The system also includes a second sensor attacked to the surgical instrument configured to measure the position and orientation of the surgical instrument. The second sensor is configured to receive the signal from the first sensor. A controller is in communication with the first sensor and/or the second sensor, and the controller executes a stored program to calculate a distance between the first sensor and the second sensor. Accordingly, visual, auditory, haptic or other feedback is provided to the clinician to guide the surgical instrument to the surgical margin.Type: ApplicationFiled: September 5, 2014Publication date: July 28, 2016Inventors: Raphael Bueno, Jayender Jagadeesan, Ferenc A. Jplesz
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Publication number: 20160192960Abstract: Embodiments of the invention provide a system and method for resecting a tissue mass. The system for resecting a tissue mass includes a surgical instrument and a first sensor for measuring a signal corresponding to the position and orientation of the tissue mass. The first sensor is dimensioned to fit insider or next to the tissue mass. The system also includes a second sensor attached to the surgical instrument configured to measure the position and orientation of the surgical instrument. The second sensor is configured to receive the signal from the first sensor. A controller is in communication with the first sensor and/or the second sensor, and the controller executes a stored program to calculate a distance between the first sensor and the second sensor. Accordingly, visual, auditory, haptic or other feedback is provided to the clinician to guide the surgical instrument to the surgical margin.Type: ApplicationFiled: March 11, 2016Publication date: July 7, 2016Inventors: Raphael Bueno, Jayender Jagadeesan, Ferenc A. Jolesz
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Publication number: 20140296327Abstract: This disclosure provides methods for surveillance, early detection and diagnosis, subtype classification, prediction of recurrence, prognosis and therapy of malignant mesothelioma based on profiles of indicator mutations in disclosed genes.Type: ApplicationFiled: October 24, 2012Publication date: October 2, 2014Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Raphael Bueno, David Sugarbaker
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Publication number: 20140294993Abstract: The present invention provides that Ras-like, estrogen-regulated, growth inhibitor (RERG) is a malignant mesothelioma biomarker of clinical course and treatment sensitivity and, itself a target for mesothelioma treatment. A low RERG level in a mesothelioma subject indicates poor prognosis. Analyzing RERG expression level along can help mesothelioma patients make treatment choices. Furthermore, mesothelioma can be treated by modulating RERG activity, for example, with treatment with estrogen or estrogen-like agents.Type: ApplicationFiled: October 24, 2012Publication date: October 2, 2014Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Raphael Bueno, David Sugarbaker
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Publication number: 20140038180Abstract: The invention provides a comprehensive, rapid, unbiased, and accurate method for identifying and/or discovering disease-associated genetic variations, e.g., disease-associated variations. The present invention further provides novel disease-associated genetic variations for use as genetic markers of disease, e.g., cancer. The invention further provides methods for assessing an individual's risk for developing a disease, e.g., cancer, by detecting the presence the novel disease-associated genetic variations of the invention.Type: ApplicationFiled: May 24, 2013Publication date: February 6, 2014Applicant: BRIGHAM & WOMEN'S HOSPITALInventors: David John Sugarbaker, Raphael Bueno
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Patent number: 8551700Abstract: The invention provides methods for diagnosing biological states or conditions based on ratios of gene expression data from tissue samples, such as cancer tissue samples. The invention also provides sets of genes that are expressed differentially in malignant pleural mesothelioma. These sets of genes can be used to discriminate between normal and malignant tissues, and between classes of malignant tissues. Accordingly, diagnostic assays for classification of tumors, prediction of tumor outcome, selecting and monitoring treatment regimens and monitoring tumor progression/regression also are provided.Type: GrantFiled: July 12, 2010Date of Patent: October 8, 2013Assignees: The Brigham and Women's Hospital, Inc., Wesleyan UniversityInventors: Gavin J. Gordon, Roderick V. Jensen, Steven R. Gullans, Li-Li Hsiao, Raphael Bueno
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Patent number: 8450057Abstract: The invention provides methods for diagnosing biological states or conditions based on ratios of gene expression data from cell or tissue samples, such as cancer cell or tissue samples. The invention also provides sets of genes that are expressed differentially in normal and cancer lung cells and tissues. These sets of genes can be used to discriminate between normal and malignant cells or tissues, and between classes of malignant cells or tissues. Accordingly, diagnostic assays for classification of tumors, prediction of tumor outcome, selecting and monitoring treatment regimens and monitoring tumor progression/regression also are provided.Type: GrantFiled: August 8, 2007Date of Patent: May 28, 2013Assignee: The Brigham and Women's Hospital, Inc.Inventors: Gavin J. Gordon, Raphael Bueno
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Publication number: 20120214163Abstract: The invention provides a comprehensive, rapid, unbiased, and accurate method for identifying and/or discovering disease-associated genetic variations, e.g., disease-associated variations. The present invention further provides novel disease-associated genetic variations for use as genetic markers of disease, e.g., cancer. The invention further provides methods for assessing an individual's risk for developing a disease, e.g., cancer, by detecting the presence the novel disease-associated genetic variations of the invention.Type: ApplicationFiled: April 13, 2012Publication date: August 23, 2012Applicant: Brigham & Women's HospitalInventors: David J. Sugarbaker, Raphael Bueno
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Publication number: 20110059854Abstract: The invention provides methods for diagnosing biological states or conditions based on ratios of gene expression data from tissue samples, such as cancer tissue samples. The invention also provides sets of genes that are expressed differentially in malignant pleural mesothelioma. These sets of genes can be used to discriminate between normal and malignant tissues, and between classes of malignant tissues. Accordingly, diagnostic assays for classification of tumors, prediction of tumor outcome, selecting and monitoring treatment regimens and monitoring tumor progression/regression also are provided.Type: ApplicationFiled: July 12, 2010Publication date: March 10, 2011Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., WESLEYAN UNIVERSITYInventors: GAVIN J. GORDON, RODERICK V. JENSEN, STEVEN R. GULLANS, LI-LI HSIAO, RAPHAEL BUENO
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Publication number: 20100196898Abstract: The invention provides a comprehensive, rapid, unbiased, and accurate method for identifying and/or discovering disease-associated genetic variations, e.g., disease-associated variations. The present invention further provides novel disease-associated genetic variations for use as genetic markers of disease, e.g., cancer. The invention further provides methods for assessing an individual's risk for developing a disease, e.g., cancer, by detecting the presence the novel disease-associated genetic variations of the invention.Type: ApplicationFiled: May 24, 2008Publication date: August 5, 2010Applicant: THE BRIGHAM & WOMEN'S HOSPITAL, INC.Inventors: David John Sugarbaker, Raphael Bueno