Patents by Inventor Raphael Clynes

Raphael Clynes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10994157
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Grant
    Filed: February 20, 2020
    Date of Patent: May 4, 2021
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20210070824
    Abstract: Provided herein are dimeric IL-7-Fc fusion proteins that include Fc domains and one or more IL-7s. Also provided herein are variant IL-7s with modifications to reduce heterogeneity and/or reduced affinity/potency. Such variant IL-7s are useful, for example, in the subject dimeric IL-7-Fc fusion proteins. The dimeric IL-7-Fc fusion proteins can be used for applications where increased IL-7 activity is useful, for example, for increasing the proliferation of lymphocyte populations in mounting an anti-tumor response in a subject in need thereof.
    Type: Application
    Filed: May 15, 2020
    Publication date: March 11, 2021
    Inventors: Matthew Bernett, John Desjarlais, Suzanne Schubbert, Christine Bonzon, Rajat Varma, Raphael Clynes
  • Publication number: 20200237635
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Application
    Filed: February 20, 2020
    Publication date: July 30, 2020
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20190262250
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Application
    Filed: March 12, 2019
    Publication date: August 29, 2019
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Patent number: 10265258
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: April 23, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20190072541
    Abstract: The presently disclosed subject matter relates to biomarkers allowing for improved diagnosis and prognosis of alopecia areata as well as effective treatments for the disease, including methods that incorporate biomarkers capable of identifying patient sub-populations that will respond to such treatments and methods that incorporate biomarkers capable of tracking the progress of such treatments.
    Type: Application
    Filed: August 15, 2016
    Publication date: March 7, 2019
    Inventors: Angela Christiano, Raphael Clynes
  • Publication number: 20180291378
    Abstract: The presently disclosed subject matter relates, in certain embodiments, to compositions and methods for the inhibition of the JAK-STAT pathway in order to induce hair growth. In certain embodiments, the presently disclosed subject matter relates to topical treatments with small molecule inhibitors of the JAK-STAT pathway to induce hair growth.
    Type: Application
    Filed: May 9, 2016
    Publication date: October 11, 2018
    Inventors: Angela Christiano, Raphael Clynes
  • Patent number: 9895301
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: February 20, 2018
    Assignee: The Trustees of Columbia University in The City of New York
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20180021235
    Abstract: The invention provides for methods for treating a hiar loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Application
    Filed: August 4, 2017
    Publication date: January 25, 2018
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Patent number: 9763866
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: September 19, 2017
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Patent number: 9737469
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: August 22, 2017
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Angela M. Christiano, Raphael Clynes
  • Patent number: 9730877
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: August 15, 2017
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20160256461
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Application
    Filed: March 10, 2016
    Publication date: September 8, 2016
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20160256374
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Application
    Filed: March 10, 2016
    Publication date: September 8, 2016
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20160058765
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Application
    Filed: August 7, 2015
    Publication date: March 3, 2016
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20160058764
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Application
    Filed: August 7, 2015
    Publication date: March 3, 2016
    Applicant: The Trustees of Columbia University in The City of New York
    Inventors: Angela M. Christiano, Raphael Clynes
  • Patent number: 9198911
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: December 1, 2015
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20140065153
    Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a JAK/STAT inhibitor.
    Type: Application
    Filed: May 2, 2013
    Publication date: March 6, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Angela M. Christiano, Raphael Clynes
  • Publication number: 20130078244
    Abstract: The invention provides for methods for controlling hair growth by administering a HLDGC modulating compound to a subject. The invention further provides for a method for screening compounds that bind to and modulate polypeptides encoded by HLDGC genes. The invention also provides methods of detecting the presence of or a predisposition to a hair-loss disorder in a human subject as well as methods of treating such disorders.
    Type: Application
    Filed: July 2, 2012
    Publication date: March 28, 2013
    Inventors: ANGELA M. CHRISTIANO, Raphael Clynes
  • Publication number: 20090214533
    Abstract: The invention is based in part on the finding that suppressing regulatory T cell function is needed in order to convert passive immunity into active antigen-specific immunity. Generally, the methods of the invention comprise at least the combination of: (1) increasing the amount of immune complexes in the subject, wherein the immune complex comprises a target antigen and a immunoglobulin molecule comprising (i) a variable region specific to the target antigen and (ii) a Fc receptor binding region; and (2) inhibiting regulatory T cell function or decreasing/depleting the regulatory T cell population in the subject.
    Type: Application
    Filed: February 17, 2009
    Publication date: August 27, 2009
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventor: Raphael Clynes