Patents by Inventor Raphael Frederick

Raphael Frederick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYPEPTIDE INHIBITORS OF LACTATE DEHYDROGENASE ACTIVITY FOR USE IN CANCER THERAPY
    Publication number: 20240116987
    Abstract: A polypeptide including the amino acid sequence of formula (I): GX1MMX2LQHGSX3X4X5QTP. These polypeptides modulate the activity of the native tetrameric lactate dehydrogenase LDH-1, by inhibiting the tetramerization of its subunits. Also, the therapeutic use of these polypeptides as a medicament, in particular for the prevention and/or the treatment of cancer.
    Type: Application
    Filed: February 1, 2022
    Publication date: April 11, 2024
    Applicant: UNIVERSITÉ CATHOLIQUE DE LOUVAIN
    Inventors: Pierre SONVEAUX, Raphaël FREDERICK, Léopold THABAULT, Maxime LIBERELLE
  • LACTATE DEHYDROGENASE INHIBITOR POLYPEPTIDES FOR USE IN THE TREATMENT OF CANCER
    Publication number: 20220289791
    Abstract: A polypeptide that modulates the activity of at least one isoform of the native tetrameric lactate dehydrogenase, and the use thereof as a medicament for the treatment of a cancer. More particularly, linear and cyclic polypeptides that inhibit the tetramerization of the lactate dehydrogenase subunits, and compositions and kits including the polypeptides.
    Type: Application
    Filed: April 30, 2020
    Publication date: September 15, 2022
    Applicant: UNIVERSITÉ CATHOLIQUE DE LOUVAIN
    Inventors: Pierre SONVEAUX, Raphaël FRÉDÉRICK, Léopold THABAULT, Lucie BRISSON, Tamara COPETTI
  • [18F]-labelled lactate derivative as PET radiotracer
    Patent number: 11260036
    Abstract: A positron emission tomography (PET) radiotracer for imaging lactate uptake, wherein the tracer is [18F]-3-fluoro-2-hydroxypropionic acid, or a pharmaceutical acceptable salt and/or solvate thereof. Also, a process for the radiosynthesis of [18F]-3-fluoro-2-hydroxypropionic acid, or a pharmaceutical acceptable salt and/or solvate thereof. Further, the use of [18F]-3-fluoro-2-hydroxypropionic acid, or a pharmaceutical acceptable salt and/or solvate thereof, for imaging lactate uptake in living cells, especially in humans.
    Type: Grant
    Filed: September 9, 2020
    Date of Patent: March 1, 2022
    Assignee: GRANDIS
    Inventors: Pierre Sonveaux, Daniel Labar, Vincent Van Hée, Gwenaël Dehon, Raphaël Frédérick
  • [18F]-LABELLED LACTATE DERIVATIVE AS PET RADIOTRACER
    Publication number: 20200405667
    Abstract: A positron emission tomography (PET) radiotracer for imaging lactate uptake, wherein the tracer is a [18F]-labelled lactate derivative. Also, a process for the radiosynthesis of the [18F]-labelled lactate derivative. Further, the use of the [18F]-labelled lactate derivative for imaging lactate uptake in living cells, especially in humans.
    Type: Application
    Filed: September 9, 2020
    Publication date: December 31, 2020
    Applicant: GRANDIS
    Inventors: Pierre SONVEAUX, Daniel LABAR, Vincent VAN HÉE, Gwenaël DEHON, Raphaël FRÉDÉRICK
  • [F]-labelled lactate derivative as pet radiotracer
    Patent number: 10799470
    Abstract: A positron emission tomography (PET) radiotracer for imaging lactate uptake, wherein the tracer is a [18F]-labelled lactate derivative which is [18F]-3-fluoro-2-hydroxypropionic acid: Also, a process for the radiosynthesis of the [18F]-labelled lactate derivative. Further, the use of the [18F]-labelled lactate derivative for imaging lactate uptake in living cells, especially in humans.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: October 13, 2020
    Assignee: GRANDIS
    Inventors: Pierre Sonveaux, Daniel Labar, Vincent Van Hée, Gwenaël Dehon, Raphaël Frédérick
  • [18F]-LABELLED LACTATE DERIVATIVE AS PET RADIOTRACER
    Publication number: 20190255002
    Abstract: A positron emission tomography (PET) radiotracer for imaging lactate uptake, wherein the tracer is a [18F]-labelled lactate derivative. Also, a process for the radiosynthesis of the [18F]-labelled lactate derivative. Further, the use of the [18F]-labelled lactate derivative for imaging lactate uptake in living cells, especially in humans.
    Type: Application
    Filed: September 8, 2017
    Publication date: August 22, 2019
    Applicant: UNIVERSITÉ CATHOLIQUE DE LOUVAIN
    Inventors: Pierre SONVEAUX, Daniel LABAR, Vincent VAN HÉE, Gwenaël DEHON, Raphaël FRÉDÉRICK
  • Beta carboline derivatives useful in the treatment of proliferative disorders
    Patent number: 9168247
    Abstract: The invention provides novel beta-carboline derivatives of formulae (Ia) and (Ib) useful in the treatment of proliferative disorders including cancer, intermediates used in their preparation, processes for preparing the same and uses thereof.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: October 27, 2015
    Assignees: FACULTES UNIVERSITAIRES NOTRE DAME DE LA PAIX, UNIVERSITE LIBRE BRUXELLES
    Inventors: Raphael Frederick, Bernard Masereel, Jeremy Reniers, Johan Wouters, Celine Bruyere, Robert Kiss, Céline Anne Marie Michelle Meinguet, Véronique Emmanuelle Julie Mathieu
  • BETA CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS
    Publication number: 20140005220
    Abstract: The invention provides novel beta-carboline derivatives of formulae (Ia) and (Ib) useful in the treatment of proliferative disorders including cancer, intermediates used in their preparation, processes for preparing the same and uses thereof.
    Type: Application
    Filed: June 24, 2011
    Publication date: January 2, 2014
    Applicants: UNIVERSITE LIBRE DE BRUXELLES, FACULTES UNIVERSITAIRES NOTRE DAME DE LA PAIX
    Inventors: Raphael Frederick, Bernard Masereel, Jeremy Reniers, Johan Wouters, Celine Bruyere, Robert Kiss
  • BETA CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS
    Publication number: 20130116273
    Abstract: The invention provides novel beta-carboline derivatives of formulae (Ia) and (Ib) useful in the treatment of proliferative disorders including cancer, intermediates used in their preparation, processes for preparing the same and uses thereof.
    Type: Application
    Filed: June 24, 2011
    Publication date: May 9, 2013
    Applicants: UNIVERSITE LIBRE DE BRUXELLES, FACULTES UNIVERSITAIRES NOTRE DAME DE LA PAIX
    Inventors: Raphael Frederick, Bernard Masereel, Jeremy Reniers, Johan Wouters, Celine Bruyere, Robert Kiss
  • SYSTEM AND METHOD FOR ASSOCIATING A REPORT WITH A CUSTOMIZABLE TEMPLATE
    Publication number: 20090063942
    Abstract: A system and method for associating a report with a customizable template is disclosed. In some embodiments, the system comprises a first data source that stores a plurality of customizable templates, a second data source that stores a plurality of reports, and logic coupled to the first and second data sources and configured to associate at least one of the plurality of reports with at least one of the plurality of customizable templates.
    Type: Application
    Filed: August 30, 2007
    Publication date: March 5, 2009
    Inventor: Raphael Frederick Laderman