Patents by Inventor Raphael Guebeli

Raphael Guebeli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Viscosity reduction of highly concentrated protein formulations
    Patent number: 12350340
    Abstract: The present invention relates to compositions of highly concentrated protein formulations showing reduced viscosity. The contained proteins in the prepared formulations are stabilized against aggregation and denaturation and are thus sufficiently storage-stable until administration to the patient.
    Type: Grant
    Filed: December 6, 2021
    Date of Patent: July 8, 2025
    Assignee: Merck Patent GmbH
    Inventors: Martin Zillmann, Alexandra Krog, Raphael Guebeli, Tanja Henzler, Christian Hildebrandt
  • VISCOSITY REDUCTION OF HIGHLY CONCENTRATED PROTEIN FORMULATIONS
    Publication number: 20220088200
    Abstract: The present invention relates to compositions of highly concentrated protein formulations showing reduced viscosity.
    Type: Application
    Filed: December 6, 2021
    Publication date: March 24, 2022
    Applicant: Merck Patent GmbH
    Inventors: Martin ZILLMANN, Alexandra KROG, Raphael GUEBELI, Tanja HENZLER, Christian HILDEBRANDT
  • Viscosity reduction of highly concentrated protein formulations
    Patent number: 11207412
    Abstract: The present invention relates to compositions of highly concentrated protein formulations showing reduced viscosity. The contained proteins in the prepared formulations are stabilized against aggregation and denaturation and are thus sufficiently storage-stable until administration to the patient.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: December 28, 2021
    Assignee: Merck Patent GmbH
    Inventors: Martin Zillmann, Alexandra Krog, Raphael Guebeli, Tanja Henzler, Christian Hildebrandt
  • VISCOSITY REDUCTION OF HIGHLY CONCENTRATED PROTEIN FORMULATIONS
    Publication number: 20190314505
    Abstract: The present invention relates to compositions of highly concentrated protein formulations showing reduced viscosity.
    Type: Application
    Filed: April 16, 2019
    Publication date: October 17, 2019
    Applicant: Merck Patent GmbH
    Inventors: Martin ZILLMANN, Alexandra KROG, Raphael GUEBELI, Tanja HENZLER, Christian HILDEBRANDT
  • Bio-functionalized stimulus-responsive dissolvable PEG-hydrogels
    Patent number: 8980278
    Abstract: The present invention is directed to a bio-functionalized stimulus-responsive dissolvable PEG-hydrogel. This inventive stimulus-responsive dissolvable PEG-hydrogel comprises a matrix of PEG-polymers, which are modified to contain at least one multifunctional fusion protein, the multifunctional fusion protein preferably comprising as components a substrate binding peptide (SBP), preferably a repetitive RGD-binding peptide and/or a ZZ-binding domain, preferably a tag for purification, and at least one N- and/or C-terminal linker. The present invention is furthermore directed to the use of such inventive stimulus-responsive dissolvable PEG-hydrogels in the treatment of lesions, in surgical dressings, for wound treating, for soft and hard tissue regeneration, for the treatment of wounds in the oral cavity, in the field of ophthalmology, in the field of periodontal defects, etc. The invention also describes a method of treatment for such diseases.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: March 17, 2015
    Assignees: Universitaetsklinikum Freiburg, Albert-Ludwigs-Universitaet Freigburg
    Inventors: Thorsten Steinberg, Wilfried Weber, Raphael Guebeli, Pascal Tomakidi, Dougal Laird
  • BIO-FUNCTIONALIZED STIMULUS-RESPONSIVE DISSOLVABLE PEG-HYDROGELS
    Publication number: 20130315996
    Abstract: The present invention is directed to a bio-functionalized stimulus-responsive dissolvable PEG-hydrogel. This inventive stimulus-responsive dissolvable PEG-hydrogel comprises a matrix of PEG-polymers, which are modified to contain at least one multifunctional fusion protein, the multifunctional fusion protein preferably comprising as components a substrate binding peptide (SBP), preferably a repetitive RGD-binding peptide and/or a ZZ-binding domain, preferably a tag for purification, and at least one N- and/or C-terminal linker. The present invention is furthermore directed to the use of such inventive stimulus-responsive dissolvable PEG-hydrogels in the treatment of lesions, in surgical dressings, for wound treating, for soft and hard tissue regeneration, for the treatment of wounds in the oral cavity, in the field of ophthalmology, in the field of periodontal defects, etc. The invention also describes a method of treatment for such diseases.
    Type: Application
    Filed: November 18, 2011
    Publication date: November 28, 2013
    Applicants: ALBERT-LUDWIGS-UNIVERSITAET FREIBURG, UNIVERSITAETSKLINIKUM FREIBURG
    Inventors: Thorsten Steinberg, Wilfried Weber, Raphael Guebeli, Pascal Tomakidi, Dougal Laird