Patents by Inventor Raphael GUZMAN

Raphael GUZMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Neural implant based on a cellulose thin film and corresponding fabrication process
    Patent number: 12544565
    Abstract: A novel ultra-thin neural implant (1) is provided that is based on a cellulose thin film (4) featuring an array (2) of electrodes (3). Due to the use of cellulose as the base material, the implant (1) can be safely handled during a micro-surgery, despite its high softness and conformability. Such an implant (1) may be useful in numerous applications ranging from electrical stimulation in neural prostheses, electro-stimulated regeneration of neural tissue to accurate recording of nerve signals. The robustness of the implant (1) results from a woven fabric (5) that is integrated in the cellulose carrier thin film (4). Several approaches for enhancing the tissue compatibility of the implant (1) are also provided.
    Type: Grant
    Filed: May 6, 2022
    Date of Patent: February 10, 2026
    Assignee: Universität Basel Vizerektorat Forschung
    Inventors: Bekim Osmani, Tino Töpper, Bert Müller, Carina Luchsinger Salinas, Raphael Guzman, Alois Hopf, Mahyar Joodaki
  • METHODS OF TREATING FIBROSIS AND HYPOXIA-ASSOCIATED DAMAGE TO PERIPHERAL NERVES
    Publication number: 20240238361
    Abstract: Described herein are methods and compositions for treating and preventing peripheral nerve injury, and more particularly hypoxia-associated tissue damage such as peripheral nerve fibrosis. The methods described include the administration of a therapeutically effective amount of a source of glutamine to peripheral nerves or one or more tissues surrounding peripheral nerves.
    Type: Application
    Filed: May 4, 2022
    Publication date: July 18, 2024
    Applicant: Temple Therapeutics BV
    Inventors: Nilabh Ghosh, Raphael Guzman
  • NEURAL IMPLANT BASED ON A CELLULOSE THIN FILM AND CORRESPONDING FABRICATION PROCESS
    Publication number: 20240226540
    Abstract: A novel ultra-thin neural implant (1) is provided that is based on a cellulose thin film (4) featuring an array (2) of electrodes (3). Due to the use of cellulose as the base material, the implant (1) can be safely handled during a micro-surgery, despite its high softness and conformability. Such an implant (1) may be useful in numerous applications ranging from electrical stimulation in neural prostheses, electro-stimulated regeneration of neural tissue to accurate recording of nerve signals. The robustness of the implant (1) results from a woven fabric (5) that is integrated in the cellulose carrier thin film (4). Several approaches for enhancing the tissue compatibility of the implant (1) are also provided.
    Type: Application
    Filed: May 6, 2022
    Publication date: July 11, 2024
    Applicant: Universität Basel Vizerektorat Forschung
    Inventors: Bekim OSMANI, Tino TÖPPER, Bert MÜLLER, Carina LUCHSINGER SALINAS, Raphael GUZMAN, Alois HOPF, Mahyar JOODAKI