Patents by Inventor Raphael Hof
Raphael Hof has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12629535Abstract: Apparatus and methods are described for use with a heating device (26) configured to heat at least a portion of a subject's body. A nanoparticle (22) is configured to be administered to the subject, the nanoparticle including at least one inner core (30) that includes a magnetic material having a Curie temperature; a phase-change-material layer (31) that surrounds the inner core and that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change selected from the group consisting of: solid to liquid, and gel to liquid, the phase-change occurring at a phase-change temperature that is lower than the Curie temperature; and an outer layer (32) disposed around the phase-change-material layer, the outer layer comprising a plurality of nano-subparticles (34) that are separated from one another, such as to form a segmented layer. Other applications are also described.Type: GrantFiled: February 20, 2018Date of Patent: May 19, 2026Assignee: NEW PHASE LTD.Inventors: Raphael Hof, Raz Khandadash, Sarah Kraus, Pazit Rukenstein
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Publication number: 20200054886Abstract: Apparatus and methods are described for use with a heating device (26) configured to heat at least a portion of a subject's body. A nanoparticle (22) is configured to be administered to the subject, the nanoparticle including at least one inner core (30) that includes a magnetic material having a Curie temperature; a phase-change-material layer (31) that surrounds the inner core and that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change selected from the group consisting of: solid to liquid, and gel to liquid, the phase-change occurring at a phase-change temperature that is lower than the Curie temperature; and an outer layer (32) disposed around the phase-change-material layer, the outer layer comprising a plurality of nano-subparticles (34) that are separated from one another, such as to form a segmented layer. Other applications are also described.Type: ApplicationFiled: February 20, 2018Publication date: February 20, 2020Applicant: NEW PHASE LTD.Inventor: Raphael HOF
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Patent number: 10172939Abstract: Apparatus and methods are described for use with a subject suffering from cancer. A nanoparticle (22) includes an inner core (30) that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change. An outer layer (32) disposed around the inner core includes a plurality of nano-spheres (34) of at least one metal, and a plurality of molecules (38) of a substance that binds preferentially with cancerous cells relative to non-cancerous cells. The nanoparticle has a volume of at least 65,000 nm3 and is elongatable into an ellipsoid, such that, when the nanoparticle is maximally elongated, each of the semi-axes defined by the ellipsoid is greater than 5 nm, and at least two of the semi axes of the ellipsoid are less than 30 nm. Other applications are also described.Type: GrantFiled: December 22, 2017Date of Patent: January 8, 2019Assignee: NEW PHASE LTD.Inventors: Raphael Hof, Raz Khandadash, Ella Fremder
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Publication number: 20180117154Abstract: Apparatus and methods are described for use with a subject suffering from cancer. A nanoparticle (22) includes an inner core (30) that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change. An outer layer (32) disposed around the inner core includes a plurality of nano-spheres (34) of at least one metal, and a plurality of molecules (38) of a substance that binds preferentially with cancerous cells relative to non-cancerous cells. The nanoparticle has a volume of at least 65,000 nm3 and is elongatable into an ellipsoid, such that, when the nanoparticle is maximally elongated, each of the semi-axes defined by the ellipsoid is greater than 5 nm, and at least two of the semi axes of the ellipsoid are less than 30 nm. Other applications are also described.Type: ApplicationFiled: December 22, 2017Publication date: May 3, 2018Applicant: NEW PHASE LTD.Inventors: Raphael HOF, Raz KHANDADASH, Ella FREMDER
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Patent number: 9872902Abstract: Apparatus and methods are described for use with a subject suffering from cancer. A nanoparticle (22) includes an inner core (30) that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change. An outer layer (32) disposed around the inner core includes a plurality of nano-spheres (34) of at least one metal, and a plurality of molecules (38) of a substance that binds preferentially with cancerous cells relative to non-cancerous cells. The nanoparticle has a volume of at least 65,000 nm3 and is elongatable into an ellipsoid, such that, when the nanoparticle is maximally elongated, each of the semi-axes defined by the ellipsoid is greater than 5 nm, and at least two of the semi axes of the ellipsoid are less than 30 nm. Other applications are also described.Type: GrantFiled: April 4, 2017Date of Patent: January 23, 2018Assignee: NEW PHASE LTD.Inventors: Raphael Hof, Raz Khandadash, Ella Fremder
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Publication number: 20170209580Abstract: Apparatus and methods are described for use with a subject suffering from cancer. A nanoparticle (22) includes an inner core (30) that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change. An outer layer (32) disposed around the inner core includes a plurality of nano-spheres (34) of at least one metal, and a plurality of molecules (38) of a substance that binds preferentially with cancerous cells relative to non-cancerous cells. The nanoparticle has a volume of at least 65,000 nm3 and is elongatable into an ellipsoid, such that, when the nanoparticle is maximally elongated, each of the semi-axes defined by the ellipsoid is greater than 5 nm, and at least two of the semi axes of the ellipsoid are less than 30 nm. Other applications are also described.Type: ApplicationFiled: April 4, 2017Publication date: July 27, 2017Applicant: NEW PHASE LTD.Inventors: Raphael HOF, Raz KHANDADASH, Ella FREMDER
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Patent number: 8172572Abstract: A dental tool displacement apparatus for use with a motorized power handle to displace a dental tool includes a tool holder having a receptacle for receiving the dental tool, and a drive arrangement. The drive arrangement defines a transmission from the motorized power handle to the tool holder such that the tool holder undergoes reciprocating motion parallel to the tool axis at a first frequency of oscillations per minute and rotates about the tool axis at a second frequency of rotations per minute. In some cases, the two types of motion are generated by an eccentric drive pin engaging an annular slot which has gear teeth along one side, thereby generating an angular rotation step of the tool holder during each reciprocating stroke. In some cases, the first frequency is at least one order of magnitude greater than the second frequency.Type: GrantFiled: August 24, 2009Date of Patent: May 8, 2012Assignee: Redent-Nova Ltd.Inventor: Raphael Hof
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Publication number: 20100330528Abstract: A dental tool displacement apparatus for use with a motorized power handle to displace a dental tool includes a tool holder having a receptacle for receiving the dental tool, and a drive arrangement. The drive arrangement defines a transmission from the motorized power handle to the tool holder such that the tool holder undergoes reciprocating motion parallel to the tool axis at a first frequency of oscillations per minute and rotates about the tool axis at a second frequency of rotations per minute. In some cases, the two types of motion are generated by an eccentric drive pin engaging an annular slot which has gear teeth along one side, thereby generating an angular rotation step of the tool holder during each reciprocating stroke. In some cases, the first frequency is at least one order of magnitude greater than the second frequency.Type: ApplicationFiled: August 24, 2009Publication date: December 30, 2010Applicant: ReDent-Nova Ltd.Inventor: Raphael Hof