Patents by Inventor Raphael Kopan

Raphael Kopan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATMENT OF PRE-CANCEROUS SKIN LESIONS
    Publication number: 20230026855
    Abstract: The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
    Type: Application
    Filed: September 16, 2022
    Publication date: January 26, 2023
    Inventors: Lynn Cornelius, Shadmehr Demehri, Raphael Kopan
  • Compositions and methods for treatment of pre-cancerous skin lesions
    Patent number: 11478549
    Abstract: The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: October 25, 2022
    Assignee: Washington University
    Inventors: Lynn Cornelius, Shadmehr Demehri, Raphael Kopan
  • COMPOSITIONS AND METHODS FOR TREATMENT OF PRE-CANCEROUS SKIN LESIONS
    Publication number: 20210128732
    Abstract: The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
    Type: Application
    Filed: January 4, 2021
    Publication date: May 6, 2021
    Inventors: Lynn Cornelius, Shadmehr Demehri, Raphael Kopan
  • Compositions and methods for treatment of pre-cancerous skin lesions
    Patent number: 10905763
    Abstract: The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: February 2, 2021
    Inventors: Lynn Cornelius, Shadmehr Demehri, Raphael Kopan
  • COMPOSITIONS AND METHODS FOR TREATMENT OF PRE-CANCEROUS SKIN LESIONS
    Publication number: 20170246299
    Abstract: The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
    Type: Application
    Filed: September 10, 2015
    Publication date: August 31, 2017
    Inventors: Lynn Cornelius, Shadmehr Demehri, Raphael Kopan
  • Methods of determining copy number of a genetic locus
    Patent number: 8586309
    Abstract: Disclosed are methods of determining in a sample, the molar ratio of a query locus to a reference locus, comprising: 1) forming one or more mixtures, each mixture comprising: a) a reference-query coupled probe comprising a nucleobase polymer comprising i) a probe reference locus comprising a probe reference allele, and ii) a probe query locus comprising a probe query allele, and b) a sample comprising i) a sample reference locus comprising a sample reference allele and ii) 0 or greater copies of a sample query locus comprising a sample query allele; 2) for each mixture, determining a) the amount of probe reference allele as a fraction of total reference allele and b) the amount of probe query allele as a fraction of total query allele; and 3) calculating the molar ratio of the sample query allele to the sample reference allele.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: November 19, 2013
    Assignee: Washington University
    Inventors: Raphael Kopan, Zhenyi Liu
  • METHODS OF DETERMINING COPY NUMBER OF A GENETIC LOCUS
    Publication number: 20110244449
    Abstract: Disclosed are methods of determining in a sample, the molar ratio of a query locus to a reference locus, comprising: 1) forming one or more mixtures, each mixture comprising: a) a reference-query coupled probe comprising a nucleobase polymer comprising i) a probe reference locus comprising a probe reference allele, and ii) a probe query locus comprising a probe query allele, and b) a sample comprising i) a sample reference locus comprising a sample reference allele and ii) 0 or greater copies of a sample query locus comprising a sample query allele; 2) for each mixture, determining a) the amount of probe reference allele as a fraction of total reference allele and b) the amount of probe query allele as a fraction of total query allele; and 3) calculating the molar ratio of the sample query allele to the sample reference allele.
    Type: Application
    Filed: October 30, 2009
    Publication date: October 6, 2011
    Inventors: Raphael Kopan, Zhenyi Liu