Patents by Inventor Raphael M. Ottenbrite

Raphael M. Ottenbrite has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymeric delivery agents and delivery agent compounds
    Patent number: 7208483
    Abstract: Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: April 24, 2007
    Assignee: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, Eugene N. Barantsevitch, Nai Fang Wang, Jun Liao, John E. Smart, Richard D. Conticello, Raphael M. Ottenbrite
  • Polymeric delivery agents and delivery agent compounds
    Publication number: 20030232085
    Abstract: Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: May 28, 2003
    Publication date: December 18, 2003
    Applicants: Emisphere Technologies, Inc., Virginia Commonwealth University
    Inventors: Sam J. Milstein, Eugene N. Barantsevitch, Nai Fang Wang, Jun Liao, John E. Smart, Richard D. Conticello, Raphael M. Ottenbrite
  • Polymeric delivery agents and delivery agents compounds
    Patent number: 6627228
    Abstract: Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: September 30, 2003
    Assignee: Emisphere Technologies, Inc.
    Inventors: Sam J. Milstein, Eugene N. Barantsevitch, Nai Fang Wang, Jun Liao, John E. Smart, Richard D. Conticello, Raphael M. Ottenbrite
  • Cytoprotective compounds
    Patent number: 6600059
    Abstract: The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.
    Type: Grant
    Filed: January 10, 2002
    Date of Patent: July 29, 2003
    Assignee: Virginia Commonwealth University
    Inventors: Richard C. Franson, Raphael M. Ottenbrite
  • Cytoprotective compounds
    Publication number: 20030078417
    Abstract: The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.
    Type: Application
    Filed: January 10, 2002
    Publication date: April 24, 2003
    Inventors: Richard C. Franson, Raphael M. Ottenbrite
  • Cytoprotective compounds
    Patent number: 6423855
    Abstract: The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.
    Type: Grant
    Filed: January 12, 2000
    Date of Patent: July 23, 2002
    Assignee: Virginia Commonwealth University
    Inventors: Richard C. Franson, Raphael M. Ottenbrite
  • Hydroxyalkyl amide analogs of ceramide
    Patent number: 6410597
    Abstract: The present invention provides methods for treating disease conditions associated with abnormal cellular proliferation, inflammation and viral infection or proliferation by the administration of ceramic analogs. The ceramic analogs appear to be specific for modulation of the enzyme PKC&zgr;.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: June 25, 2002
    Assignee: Virginia Commonwealth University
    Inventors: Erhard Bieberich, Raphael M. Ottenbrite, Robert K. Yu, Helen Fillmore, William C. Broaddus
  • Cytoprotective Compounds
    Publication number: 20020002296
    Abstract: The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.
    Type: Application
    Filed: January 12, 2000
    Publication date: January 3, 2002
    Inventors: Richard C. Franson, Raphael M. Ottenbrite
  • Cytoprotective compounds
    Patent number: 6020510
    Abstract: The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.
    Type: Grant
    Filed: February 2, 1998
    Date of Patent: February 1, 2000
    Assignee: Virginia Commonwealth University
    Inventors: Richard C. Franson, Raphael M. Ottenbrite
  • Cytoprotective fatty moiety compounds
    Patent number: 6020489
    Abstract: Water or lipid soluble, pharmacologically active, antioxidant, anti-phospholipase compounds that are chemically defined. The compounds protect mammalian cells by inhibiting PLA.sub.2 and preventing oxidation. In particular, each compound has at least two fatty moieties and no active hydroxy group. The compound may also have at least one ionizable group, which may be a carboxyl group, and each of the fatty moieties has from sixteen to twenty carbon atoms and at least one cis-unsaturated double bond.
    Type: Grant
    Filed: March 18, 1997
    Date of Patent: February 1, 2000
    Assignee: Virginia Commonwealth University
    Inventors: Richard C. Franson, Raphael M. Ottenbrite
  • Cytoprotective compounds
    Patent number: 5859271
    Abstract: The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: January 12, 1999
    Assignee: Virginia Commonwealth University
    Inventors: Richard C. Franson, Raphael M. Ottenbrite
  • Antioxidant, antiphospholipase derivatives of ricinoleic acid
    Patent number: 5659049
    Abstract: Water or lipid soluble, pharmacologically active, antioxidant, anti-phospholipase compounds that are chemically defined. The compounds protect mammalian cells by inhibiting PLA.sub.2 and preventing oxidation. In particular, each compound has at least two fatty moieties and no active hydroxy group. The compound may also have at least one ionizable group, which may a carboxyl group, and each of the fatty moieties has from sixteen to twenty carbon atoms and at least one cis-unsaturated double bond.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: August 19, 1997
    Assignee: Virginia Commonwealth University
    Inventors: Richard C. Franson, Raphael M. Ottenbrite
  • Cytoprotective fatty moiety compounds
    Patent number: 5659055
    Abstract: Water or lipid soluble, pharmacologically active, antioxidant, anti-phospholipase compounds that are chemically defined. The compounds protect mammalian cells by inhibiting PLA.sub.2 and preventing oxidation. In particular, each compound has at least two fatty moieties and no active hydroxy group. The compound may also have at least one ionizable group, which may be a carboxyl group, and each of the fatty moieties has from sixteen to twenty carbon atoms and at least one cis-unsaturated double bond.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 19, 1997
    Assignee: Virginia Commonwealth University
    Inventors: Richard C. Franson, Raphael M. Ottenbrite
  • Polyimide from bis(N-isoprenyl)s of aryl diamides
    Patent number: 5200497
    Abstract: A process and polyimide product formed by the reaction of a bismaleimide with a bis(amidediene) wherein the bis(amidediene) is formed by reacting an excess of an acid chloride with 1,4-N,N'-diisoprenyl-2,3,5,6-tetramethyl benzene.
    Type: Grant
    Filed: August 16, 1990
    Date of Patent: April 6, 1993
    Assignee: The United States of America as represented by the Adminstrator, National Aeronautics and Space Administration
    Inventors: Joseph G. Smith, Jr., Raphael M. Ottenbrite
  • Bis[4-(3,4-dimethylene-pyrrolidyl)phenyl] methane
    Patent number: 4895915
    Abstract: A polyimide composition consisting essentially of recurring units having the following structural formula: ##STR1## is produced by the copolymerization of a bismaleimide and bis[4-(3,4-dimethylenepyrrolidyl)phenyl] methane.
    Type: Grant
    Filed: February 16, 1989
    Date of Patent: January 23, 1990
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventor: Raphael M. Ottenbrite
  • Bis[4-(3,4-dimethylenepyrrolidyl)phenyl]methane
    Patent number: 4851544
    Abstract: A polyimide composition consisting essentially of recurring units having the following structural formula: ##STR1## is produced by the copolymerization of a bismaleimide and bis[4-(3,4-dimethylenepyrrolidyl)phenyl]methane.
    Type: Grant
    Filed: July 19, 1988
    Date of Patent: July 25, 1989
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventor: Raphael M. Ottenbrite