Patents by Inventor Raphael Mannino

Raphael Mannino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10716860
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: July 21, 2020
    Assignees: Matinas BioPharma Nanotechnologies, Inc., Rutgers, The State University of New Jersey
    Inventors: Raphael Mannino, Ruying Lu
  • Publication number: 20180185491
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Application
    Filed: November 13, 2017
    Publication date: July 5, 2018
    Inventors: Raphael Mannino, Ruying Lu
  • Patent number: 9775907
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: October 3, 2017
    Assignee: MATINAS BIOPHARMA NANOTECHNOLOGIES, INC.
    Inventors: Raphael Mannino, Ruying Lu
  • Patent number: 9370572
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: June 21, 2016
    Assignee: AQUARIUS BIOTECHNOLOGIES, INC
    Inventors: Raphael Mannino, Ruying Lu
  • Publication number: 20150297725
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Application
    Filed: July 30, 2013
    Publication date: October 22, 2015
    Applicants: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, AQUARIUS BIOTECHNOLOGIES, INC.
    Inventors: RAPHAEL MANNINO, RUYING LU
  • Publication number: 20150147380
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Application
    Filed: January 29, 2015
    Publication date: May 28, 2015
    Inventors: RAPHAEL MANNINO, RUYING LU
  • Publication number: 20150140074
    Abstract: Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
    Type: Application
    Filed: January 29, 2015
    Publication date: May 21, 2015
    Inventors: RAPHAEL MANNINO, RUYING LU
  • Publication number: 20140220108
    Abstract: The present invention provides, in part, cochleate compositions and methods for making and using same.
    Type: Application
    Filed: May 4, 2012
    Publication date: August 7, 2014
    Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, COORDINATED PROGRAM DEVELOPMENT, LLC
    Inventors: Ruying Lu, Raphael Mannino
  • Publication number: 20080009457
    Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.
    Type: Application
    Filed: January 11, 2007
    Publication date: January 10, 2008
    Applicant: BioDelivery Sciences International, Inc.
    Inventors: Susan Gould-Fogerite, Raphael Mannino, Patrick Ahl, Gaofeng Shang, Zi Chen, Sara Krause-Elsmore
  • Publication number: 20070237814
    Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
    Type: Application
    Filed: January 11, 2007
    Publication date: October 11, 2007
    Applicants: BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New Jersey
    Inventors: Raphael Mannino, Susan Gould-Fogerite, Sara Krause-Elsmore, David Delmarre, Ruying Lu
  • Publication number: 20060029656
    Abstract: Disclosed are cochleates and cochleate compositions that associated with an replacement enzyme component and/or a plasmid component that encodes a replacement enzyme. Also disclosed are methods of making and using the compositions of the invention, including methods of administration. Use of the invention provides safe, effective and efficient delivery of replacement enzymes and/or plasmids encoding the same in a variety of dosage forms.
    Type: Application
    Filed: February 3, 2005
    Publication date: February 9, 2006
    Applicant: BioDelivery Sciences International, Inc.
    Inventors: Francis O'Donnell, Raphael Mannino, Susan Gould-Fogerite
  • Publication number: 20060019870
    Abstract: Disclosed herein are cochleates and cochleate compositions associated with an apoprotein component and/or a plasmid component that encodes an apoprotein. Also disclosed are methods of making and using the compositions of the invention, including methods of administration. Use of the invention provides safe, effective and efficient delivery of apoproteins and/or plasmids encoding the same in a variety of dosage forms.
    Type: Application
    Filed: January 28, 2005
    Publication date: January 26, 2006
    Inventors: Francis O'Donnell, Susan Gould-Fogerite, Raphael Mannino
  • Publication number: 20050186265
    Abstract: A process for producing a small-sized, lipid-based cochleates. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.
    Type: Application
    Filed: January 18, 2005
    Publication date: August 25, 2005
    Applicant: University of Medicine and Dentistry of New Jersey
    Inventors: Leila Zarif, Tuo Jin, Ignacio Segarra, Raphael Mannino
  • Publication number: 20050129661
    Abstract: An integrative DNA vector and one or more viral proteins having affinity for DNA are packaged in cochleate precipitates. The integrative DNA vector contains one or more therapeutic nucleotide sequences that are preferably positioned between DNA substrates for the proteins. Upon contact with a lipid bilayer of a target cell, the cochleate vector structure delivers one or more of the therapeutic nucleotide sequences and one or more proteins to the interior of the target cell. Upon entry into the cell, the proteins facilitate the integration of the therapeutic nucleotide sequence into the genome of the host cell.
    Type: Application
    Filed: January 24, 2005
    Publication date: June 16, 2005
    Applicants: University of Medicine and Dentistry of New Jersey, University of Maryland
    Inventors: David Margolis, Susan Gould-Fogerite, Raphael Mannino
  • Publication number: 20050013854
    Abstract: Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.
    Type: Application
    Filed: April 9, 2004
    Publication date: January 20, 2005
    Inventors: Raphael Mannino, Susan Gould-Fogerite, Sara Krause-Elsmore, David Delmarre, Ruying Lu
  • Publication number: 20050013855
    Abstract: Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.
    Type: Application
    Filed: April 9, 2004
    Publication date: January 20, 2005
    Applicants: BioDelivery Sciences International, Inc., University of Medicine and Dentistry of New Jersey
    Inventors: Susan Gould-Fogerite, Raphael Mannino, Patrick Ahl, Gaofeng Shang, Zi Chen, Sara Krause-Elsmore
  • Publication number: 20050008686
    Abstract: The present invention provides novel fragile nutrient cochleates that generally include one or more encochleated fragile nutrients, e.g., beta carotene, and methods for making the same. Also provided are methods for the use and administration of the fragile nutrient cochleates of the invention.
    Type: Application
    Filed: January 15, 2004
    Publication date: January 13, 2005
    Inventors: Raphael Mannino, Sara Krause-Elsmore, Susan Gould-Fogerite, David Delmarre, Feng Tan
  • Patent number: 6153217
    Abstract: A process for producing a small-sized, lipid-based cochleate is described. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structure by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca.sup.2+ or Zn.sup.2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing pharmaceutical agents or biologically relevant molecules. Small-sized cochleates may be administered orally or through the mucosa to obtain an effective method of treatment.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: November 28, 2000
    Assignees: Biodelivery Sciences, Inc., University of Medicine and Denistry of New Jersey
    Inventors: Tuo Jin, Leila Zarif, Raphael Mannino