Abstract: The above-captioned compounds display anti-microbial activity, e.g. anti-bacterial and anti-fungal, and are, in addition, useful as intermediates in the manufacture of prostanoic acid derivatives.

Abstract: 11.beta.-Alkyl-2-azaestratrienes, displaying valuable pharmacological properties, e.g. anti-viral and hypolipemic, are manufactured by a total synthesis originating with dihydroresorcinol.

Abstract: 2-Azasteroids, displaying valuable pharmacological properties, e.g. anti-viral, are manufactured by a total synthesis originating with dihydroresorcinol.

Abstract: The administration of aldosterone inhibitors of the spirolactone structural type prior to and during treatment with anti-neoplastic agents such as adriamycin results in retention of the desired activity of the latter substances while inhibiting their undesirable cardiotoxic properties.

Abstract: The present invention encompasses compounds of the formula ##SPC1##Wherein R represents hydrogen or lower alkyl having 1-7 carbon atoms and wherein one X represents (nitrogen) N and the other X represents methylidyne. The compounds of the present invention are prepared by the methods set out in the following scheme: ##SPC2##Wherein R and X are as defined above. Compounds of the present invention are useful anti-inflammatory agents.

Abstract: 3-(Optionally oxygenated)-5-oxocyclopent-1-enealkanoic acids and their alkyl esters are allowed to react with appropriate alkenyl copper, alkenyl boron, alkynyl boron, alkynyl gallium or alkynyl aluminum compounds to produce the corresponding 2-(3-hydroxy-3-[optionally alkylated]-1-alkenyl)cyclopentanealkanoic acids, 2-(3-hydroxy-3-[optionally alkylated]-1-alkynyl)cyclopentanealkanoic acids and their esters. The prostaglandin derivatives so produced are valuable and useful as pharmacological agents as is evidenced by their central nervous system-affective, anti-bacterial, anti-fungal and prostaglandin antagonist activity.

Abstract: 2-Alkoxy-4-hydroxy-5-oxocyclopent-1-eneheptanoic acid and its lower alkyl esters are reduced with metallic hydrides to yield the corresponding 3-hydroxy-5-oxo-cyclopent-1-eneheptanoic acid and its esters. The latter compounds are valuable intermediates in the preparation of pharmacologically active prostaglandin derivatives.

Abstract: 16-Oxygenated prostanoic acid derivatives, displaying valuable pharmacological properties, e.g. gastric anti-secretory, are produced by reaction of an (optionally 3-oxygenated)-5-oxocyclopent-1-enealkanoic/alkenoic acid or ester with the appropriate organometallic reagent.

Abstract: A novel total synthesis of 11-alkyl steroids, utilizing readily available and inexpensive raw materials, is described. The resulting products are useful and novel pharmacological agents possessing, for example, selective hormonal properties.

Abstract: Novel mono- and dialkylated prostynoic acid derivatives, prepared by condensation of a suitably substituted cyclopentene carboxylic acid or ester with a suitable organometallic alkynyl derivative, display valuable pharmacological properties. For example, they are potent inhibitors of gastric secretion.