Patents by Inventor Raphael Rubin

Raphael Rubin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7285487
    Abstract: A network for interconnecting processing element nodes which supports rich interconnection while having a number of switching elements which is linear in the number of processing elements interconnected. Processing elements connect to the lowest level of the tree and the higher levels of the tree make connections between the processing elements. The processing elements may be laid out in a two dimensional grid and one or more horizontal and vertical trees may be used to connect between the processing elements with corner switches used to connect between the horizontal and vertical trees. The levels of the tree can be accommodated in multiple layers of metalization such that the entire layout requires a two-dimensional area which is linear in the number of processing elements supported.
    Type: Grant
    Filed: July 23, 2004
    Date of Patent: October 23, 2007
    Assignee: California Institute of Technology
    Inventors: André DeHon, Raphael Rubin
  • Publication number: 20050063373
    Abstract: A network for interconnecting processing element nodes which supports rich interconnection while having a number of switching elements which is linear in the number of processing elements interconnected. Processing elements connect to the lowest level of the tree and the higher levels of the tree make connections between the processing elements. The processing elements may be laid out in a two dimensional grid and one or more horizontal and vertical trees may be used to connect between the processing elements with corner switches used to connect between the horizontal and vertical trees. The levels of the tree can be accommodated in multiple layers of metalization such that the entire layout requires a two-dimensional area which is linear in the number of processing elements supported.
    Type: Application
    Filed: July 23, 2004
    Publication date: March 24, 2005
    Inventors: Andre DeHon, Raphael Rubin
  • Patent number: 6509457
    Abstract: AAC-11 polypeptide and DNA (RNA) encoding AAC-11 polypeptide and methods for producing such polypeptide by recombinant techniques. Also, methods of using the AAC-11 polynucleotides and/or polypeptides to inhibit apoptosis in cells. Further, methods of using agonists or antagonists to AAC-11 polypeptides to inhibit or induce apoptosis in cells.
    Type: Grant
    Filed: January 20, 1999
    Date of Patent: January 21, 2003
    Assignee: Thomas Jefferson University
    Inventors: Raphael Rubin, Manorama Tewari
  • Patent number: 6340674
    Abstract: A method of inhibiting the proliferation and causing the differentiation of undifferentiated cells comprising contacting the undifferentiated cells with an effective amount of an antisense oligonucleotide having a sequence which is complementary to a region of the IGF-1 receptor RNA. The sequence of the antisense oligonucleotide is selected from an oligodeoxynucleotide sequence complementary to codons −29 to −24 of the signal sequence of the IGF-1 receptor and an oligoribodeoxynucleotide sequence complementary to codons 1 to 309 of the sequence of the IGF-1 receptor. The oligoribonucleotide sequence may be provided by an expression vector.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: January 22, 2002
    Assignee: Thomas Jefferson University
    Inventors: Renato Baserga, Christian Sell, Raphael Rubin
  • Patent number: 6331526
    Abstract: A method of inhibiting the proliferation and causing the differentiation of undifferentiated cells comprising contacting the undifferentiated cells with an effective amount of an antisense oligonucleotide having a sequence which is complementary to a region of the IGF-1 receptor RNA. The sequence of the antisense oligonucleotide is selected from an oligodeoxynucleotide sequence complementary to codons −29 to −24 of the signal sequence of the IGF-1 receptor and an oligoribonucleotide sequence complementary to codons 1 to 309 of the sequence of the IGF-1 receptor. The oligoribonucleotide sequence may be provided by an expression vector.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: December 18, 2001
    Assignee: Thomas Jefferson University
    Inventors: Renato Baserga, Christian Sell, Raphael Rubin
  • Patent number: 6274562
    Abstract: A method of inhibiting the proliferation and causing the differentiation of undifferentiated cells comprising contacting the undifferentiated cells with an effective amount of an antisense oligonucleotide having a sequence which is complementary to a region of the IGF-1 receptor RNA. The sequence of the antisense oligonucleotide is selected from an oligodeoxynucleotide sequence complementary to codons −29 to −24 of the signal sequence of the IGF-1 receptor and an oligoribodeoxynucleotide sequence complementary to codons 1 to 309 of the sequence of the IGF-1 receptor. The oligoribodeoxynucleotide sequence may be provided by an expression vector.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: August 14, 2001
    Assignee: Thomas Jefferson University
    Inventors: Renato Baserga, Christian Sell, Raphael Rubin
  • Patent number: 5643788
    Abstract: A method of inhibiting the proliferation and causing the differentiation of undifferentiated cells comprising contacting the undifferentiated cells with an effective amount of an antisense oligonucleotide having a sequence which is complementary to a region of the IGF-1 receptor RNA. The sequence of the antisense oligonucleotide is selected from an oligodeoxynucleotide sequence complementary to codons -29 to -24 of the signal sequence of the IGF-1 receptor and an oligoribonucleotide sequence complementary to codons 1 to 309 of the sequence of the IGF-1 receptor. The oligoribonucleotide sequence may be provided by an expression vector.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 1, 1997
    Assignee: Thomas Jefferson University
    Inventors: Renato Baserga, Christian Sell, Raphael Rubin